scholarly journals Identification of erythromycin derivative from the preputial gland of the lesser bandicoot rat

2000 ◽  
Vol 76 (5) ◽  
pp. 73-75
Author(s):  
Soundarapandian KANNAN ◽  
Govindaraju ARCHUNAN
Keyword(s):  
Preputial Gland

scholarly journals Nucleotide sequence of rat preputial gland beta-glucuronidase cDNA and in vitro insertion of its encoded polypeptide into microsomal membranes.

1986 ◽  
Vol 83 (19) ◽  
pp. 7292-7296 ◽  
Author(s):  
Y. Nishimura ◽  
M. G. Rosenfeld ◽  
G. Kreibich ◽  
U. Gubler ◽  
D. D. Sabatini ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Preputial Gland ◽  
Microsomal Membranes

scholarly journals A LIPOSOMAL COMPOSITION OF MUSC DEER PREPUTIAL GLAND EXTRACT AS A NEW AGENT OF ADAPTOGENIC ACTION

Biomeditsina ◽  
2019 ◽  
pp. 34-45
Author(s):  
V. N. Karkischenko ◽  
M. S. Dulya ◽  
R. A. Ageldinov ◽  
S. L. Lyublinskiy ◽  
N. N. Karkischenko
Keyword(s):  
Mass Spectrometry ◽  
Size Distribution ◽  
Biologically Active ◽  
Musk Deer ◽  
Preputial Gland ◽  
Active Components ◽  
Liposomal Form ◽  
Uniform Size ◽  
Transmission Microscopy ◽  
Gland Extract

For the first time, a liposomal form of a new original drug based on the Siberian musk deer preputial gland extract was obtained and characterized. An effective and scalable method of high-pressure homogenization was used for preparative extraction of liposomes from musk extracts. For the obtained liposomal product, such indicators as the quality of size distribution, homogeneity and the degree of inclusion of biologically active components were characterized using the methods of dynamic light scattering, transmission microscopy, preparative and analytical chromatography and chromatography-mass spectrometry. A homogeneous dispersion of musk liposomes with a uniform size distribution was obtained, with the maximum distribution values being achieved at 50 and 240 nm. The ζ-potential of the obtained nanoparticles of –35...–47 mV confirmed a high physicochemical stability of the developed liposomal dispersion. According to the gel filtration chromatography and mass spectrometry results, the degree of inclusion of the target musk extract components in the liposomes was 55–75% in terms of steroid and total protein values. The obtained quality indicators indicate that the developed liposomal composition of musk deer extracts can be used as a high-effective natural adaptogen.

Bacteriological and pathological investigations on the preputial glands of one-year-old C57BL/6NCrl mice maintained in individually ventilated cages

2021 ◽  
pp. 002367722110559
Author(s):  
Gianfranco Di Caro ◽  
Lucia Minoli ◽  
Marzia Ferrario ◽  
Gerardo Marsella ◽  
Gianpaolo Milite ◽  
...  
Keyword(s):  
Bacterial Load ◽  
Laboratory Animals ◽  
Inflammatory Cell Infiltrate ◽  
Preputial Gland ◽  
Inflammatory Score ◽  
Haematological Changes ◽  
Preputial Glands ◽  
One Year ◽  
Inflammatory Changes ◽  
Klebsiella Spp

Spontaneous infections of the preputial glands represent overlooked health problems in mice that could raise welfare concerns and potentially confound scientific experiments. Agents involved in preputial gland infections have rarely been investigated, with opportunistic pathogens of laboratory animals usually detected in inflamed preputial glands. The aim of this study was to investigate the prevalence of bacterial infection in the preputial glands and the relationship between haematological and pathological changes and infection status. We analysed 40 preputial glands from 20 one-year-old C57BL/6NCrl male mice by using bacteriology, haematology and pathology. Bacteria were isolated from 16/20 (80%) mice, for a total of 32/40 (80%) examined preputial glands. Enterobacter cloacae, Pasteurella spp., Klebsiella spp. and Staphylococcus aureus were identified in 35%, 17.5%, 15% and 12.5% of the examined glands, respectively. Preputial gland inflammation was identified in 29/40 (72.5%) glands and was classified as chronic interstitial adenitis in 27 cases and suppurative adenitis in the remaining two glands. No haematological changes were found in mice with infected glands. Histologically, the presence of intralesional bacteria, intraluminal necrotic material, intraluminal keratin accumulation, interstitial inflammatory cell infiltrate and granulocytes (intraluminal and/or interstitial), along with total inflammatory score and total histopathological score, were significantly increased in infected glands and correlated with the bacterial load. Most severe inflammatory changes were identified after S. aureus infection, while ductal hyperkeratosis was significantly increased in glands infected with Klebsiella spp. In conclusion, preputial gland infection was a common event in one-year-old C57BL/6NCrl mice, and bacterial load correlated with pathological findings, while systemic effects were not highlighted by haematology.

EFFECT OF α-MELANOCYTE-STIMULATING HORMONE AND OVARIAN STEROIDS ON PREPUTIAL GLAND FUNCTION IN THE FEMALE RAT

1981 ◽  
Vol 90 (1) ◽  
pp. 53-58 ◽  
Author(s):  
S. M. DONOHOE ◽  
A. J. THODY ◽  
S. SHUSTER
Keyword(s):  
Pituitary Hormones ◽  
Female Rats ◽  
Male Rats ◽  
Female Rat ◽  
Preputial Gland ◽  
Melanocyte Stimulating Hormone ◽  
Experienced Male ◽  
Hypophysectomized Rats ◽  
Gland Function ◽  
Preputial Glands

Sexually experienced male rats were used to test the attractiveness of preputial gland odours of female rats. The male rats showed a clear preference for the preputial gland odours of hypophysectomized females given oestradiol benzoate (OB) for 3 or 8 days to those of control rats. Progesterone treatment had no effect on the attractiveness of the preputial gland odours of OB-treated hypophysectomized female rats. Administration of α-MSH for either 3 or 8 days, on the other hand, increased the attractiveness to male rats of preputial gland odours of OB-treated hypophysectomized females and the presence of progesterone produced no further change. When administered alone α-MSH had no effect on the attractiveness of the preputial gland odours. Other pituitary hormones, such as ACTH and prolactin, had no effect on the attractiveness of preputial gland odours of OB-treated hypophysectomized rats when administered for 3[unk]days. An increase in preputial gland size was only seen when OB, progesterone and α-MSH were administered together. It would appear that no relationship exists between the size of the preputial glands and their ability to attract male rats. It is concluded that, while α-MSH and progesterone may be important in controlling growth of the preputial glands, an interaction between α-MSH and oestrogen is more important for regulating the production of sex attractants by the preputial glands.

WEIGHT GAIN AND [3H]THYMIDINE INCORPORATION IN ACCESSORY SEX GLANDS OF CASTRATED MALE RATS AFTER PHYSIOLOGICAL DOSES OF TESTOSTERONE

1974 ◽  
Vol 77 (3) ◽  
pp. 597-603 ◽  
Author(s):  
P. Tuohimaa ◽  
K.-O. Söderström
Keyword(s):  
Steady State ◽  
Thymidine Incorporation ◽  
Control Level ◽  
Labelling Index ◽  
Male Rats ◽  
Ventral Prostate ◽  
Preputial Gland ◽  
Accessory Sex Glands ◽  
Physiological Dose ◽  
Initial Peak

ABSTRACT One month after castration male rats were injected daily with a physiological dose (2 × 50 μg) of testosterone for 10 days. At certain time intervals a pair of rats were injected with [3H]thymidine and killed one hour later. The accessory sex organs were weighed and processed for radioautography. The ventral prostate, dorsal prostate, seminal vesicle and coagulating gland showed a 2.5–4 fold increase in weight during treatment for 10 days with testosterone, whereas the weight of the preputial gland remained unchanged. The daily physiological dose of testosterone clearly increased the [3H] thymidine incorporation in all the accessory sex glands except the preputial gland where only a slight initial peak was observed. The labelling index showed a peak value 42–90 hours after the start of the testosterone treatment. After the peak the labelling index showed some fluctuation and then decreased to a steady state level, which was of the same magnitude as the control level in uncastrated rats. This study shows that the 42–90 hour peak in the labelling index is dose-dependent whereas the steady state labelling index is independent of the testosterone dose. The refractory time to the initial peak of the labelling index is also independent of the testosterone dose.

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