scholarly journals The relationship between intestinal goblet cells and the immune response

2020 ◽  
Vol 40 (10) ◽  
Author(s):  
Mingming Zhang ◽  
Chenchen Wu
Keyword(s):  
Immune Response ◽  
Protective Effect ◽  
Barrier Function ◽  
Pathogenic Bacteria ◽  
Goblet Cells ◽  
The Body ◽  
Pathogenic Microorganisms ◽  
Mucus Layer ◽  
Antigen Presenting ◽  
The Relationship

Abstract Goblet cells (GCs) are single-cell glands that produce and secrete mucin. Mucin forms a mucus layer, which can separate the materials in cavities from the intestinal epithelium and prevent the invasion of pathogenic microorganisms in various ways. GCs can also participate in the immune response through nonspecific endocytosis and goblet cell-associated antigen passages (GAPs). GCs endocytose soluble substances from the lumen and transmit antigens to the underlying antigen-presenting cells (APCs). A variety of immuno-regulatory factors can promote the differentiation, maturation of GCs, and the secretion of mucin. The mucin secreted by GCs forms a mucus layer, which plays an important role in resisting the invasion of foreign bacteria and intestinal inherent microorganisms, regulating the immune performance of the body. Therefore, the present study mainly reviews the barrier function of the mucus layer, the mucus secreted by goblet cells, the protective effect against pathogenic bacteria, the delivery of luminal substances through GAPs and the relationship between GCs and the immune response.

scholarly journals Regulation of the Migration of Distinct Dendritic Cell Subsets

2021 ◽  
Vol 9 ◽  
Author(s):  
Meng Feng ◽  
Shuping Zhou ◽  
Yong Yu ◽  
Qinghong Su ◽  
Xiaofan Li ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Immune Responses ◽  
The Body ◽  
Inflammatory Factors ◽  
Pathogenic Microorganisms ◽  
Migration Patterns ◽  
Dendritic Cell Subsets ◽  
And Migration ◽  
Antigen Presenting

Dendritic cells (DCs), a class of antigen-presenting cells, are widely present in tissues and apparatuses of the body, and their ability to migrate is key for the initiation of immune activation and tolerogenic immune responses. The importance of DCs migration for their differentiation, phenotypic states, and immunologic functions has attracted widespread attention. In this review, we discussed and compared the chemokines, membrane molecules, and migration patterns of conventional DCs, plasmocytoid DCs, and recently proposed DC subgroups. We also review the promoters and inhibitors that affect DCs migration, including the hypoxia microenvironment, tumor microenvironment, inflammatory factors, and pathogenic microorganisms. Further understanding of the migration mechanisms and regulatory factors of DC subgroups provides new insights for the treatment of diseases, such as infection, tumors, and vaccine preparation.

scholarly journals Corneocytes: Relationship between Structural and Biomechanical Properties

2021 ◽  
pp. 1-16
Author(s):  
Ana S. Évora ◽  
Michael J. Adams ◽  
Simon A. Johnson ◽  
Zhibing Zhang
Keyword(s):  
Surface Area ◽  
Barrier Function ◽  
Biomechanical Properties ◽  
The Body ◽  
Mechanical Resistance ◽  
Cornified Envelope ◽  
Skin Cells ◽  
Exposed Skin ◽  
Immature Cells ◽  
The Relationship

<b><i>Background:</i></b> Skin is the interface between an organism and the external environment, and hence the stratum corneum (SC) is the first to withstand mechanical insults that, in certain conditions, may lead to integrity loss and the development of pressure ulcers. The SC comprises corneocytes, which are vital elements to its barrier function. These cells are differentiated dead keratinocytes, without organelles, composed of a cornified envelope and a keratin-filled interior, and connected by corneodesmosomes (CDs). <b><i>Summary:</i></b> The current review focusses on the relationship between the morphological, structural, and topographical features of corneocytes and their mechanical properties, to understand how they assist the SC in maintaining skin integrity and in responding to mechanical insults. <b><i>Key Messages:</i></b> Corneocytes create distinct regions in the SC: the inner SC is characterized by immature cells with a fragile cornified envelope and a uniform distribution of CDs; the upper SC has resilient cornified envelopes and a honeycomb distribution of CDs, with a greater surface area and a smaller thickness than cells from the inner layer. The literature indicates that this upward maturation process is one of the most important steps in the mechanical resistance and barrier function of the SC. The morphology of these cells is dependent on the body site: the surface area in non-exposed skin is about 1,000–1,200 μm<sup>2</sup>, while for exposed skin, for example, the cheek and forehead, is about 700–800 μm<sup>2</sup>. Corneocytes are stiff cells compared to other cellular types, for example, the Young’s modulus of muscle and fibroblast cells is typically a few kPa, while that of corneocytes is reported to be about hundreds of MPa. Moreover, these skin cells have 2 distinct mechanical regions: the cornified envelope (100–250 MPa) and the keratin matrix (250–500 MPa).

scholarly journals 138 Effects of Diet Complexity and L-Threonine Supplementation on Immune Response and Intestinal Barrier Function in Nursery Pigs

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 99-99
Author(s):  
Bonjin Koo ◽  
Janghan Choi ◽  
Chengbo Yang ◽  
Charles Martin Nyachoti
Keyword(s):  
Gene Expression ◽  
Immune Response ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Goblet Cells ◽  
Proximal Colon ◽  
Intestinal Barrier Function ◽  
Experimental Unit ◽  
Animal Products ◽  
Nursery Pigs

Abstract The aim was to investigate the effects of diet complexity and L-Thr supplementation on immune response and intestinal barrier function in nursery pigs. Thirty-two pigs (7.23 ± 0.48 kg of body weight) were randomly assigned dietary treatments in a 2 × 2 factorial arrangement based on diet complexity (complex or simple) and L-Thr supplementation (standard, NRC 2012 or 15% more). The complex diet contained fish meal, plasma protein and dried whey to mimic a conventional nursery diet. The simple diet was formulated with corn, wheat, and soybean meal and did not contain any animal products. Pigs were individually housed and fed experimental diets ad libitum for 14 d. All data were analyzed using mixed procedure of SAS with the individual pen as the experimental unit. Pigs fed the simple diet had greater (P &lt; 0.05) plasma interleukin (IL)-6 and IL-10 concentrations compared to those fed the complex diet. Pigs fed the simple diet tended to show greater (P &lt; 0.10) expression of genes encoding for tumor necrosis factor-α, claudin-1, and zonula occludens-1 in the jejunum compared to those fed the complex diet. The addition of L-Thr increased (P &lt; 0.05) villus height and numbers of both villi and crypt goblet cells in the jejunum and deepened (P &lt; 0.05) crypts in the proximal colon. Also, L-Thr-supplemented diets upregulated (P &lt; 0.05) the expression of the gene encoding for occludin and tended to downregulate (P &lt; 0.10) IL-6 gene expression in the jejunum. Trends (P &lt; 0.10) for interaction between diet complexity and L-Thr supplementation were observed in villus height:crypt depth ratio, the number of goblet cells, and IL-6 gene expression in the jejunum. In conclusion, feeding a simple diet stimulated the immune system of nursery pigs compared to a complex diet. Dietary L-Thr supplementation fortified intestinal structure and function.

scholarly journals Leptin’s and antigen-presenting cells’ functions in periodontitis – an overview / Leptin e as funções das células que apresentam antigénios na periodontite - uma visão geral

2021 ◽  
Vol 4 (2) ◽  
pp. 8011-8019
Author(s):  
Giovanna Ganem Favero ◽  
Isabela Lopes Martin ◽  
Fernanda Pereira da Silva Albino ◽  
Carlos Eduardo Fontana ◽  
Sérgio Luiz Pinheiro ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Immune Responses ◽  
Inflammatory Responses ◽  
Antigen Presenting Cells ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Inflammatory Immune Response ◽  
Antigen Presenting ◽  
The Relationship

Leptin is a hormone synthesized predominantly by white adipose tissue. Its production levels are directly proportional to the total mass of this tissue in an individual’s body. Apart from its classic role in the regulation of hunger and satiety, it also plays an important part in scenarios involving innate and adaptive immune responses. It has been discovered that leptin levels are altered in a variety of inflammatory responses, such as periodontitis, a condition which derives from a persistent inflammatory immune response from a host facing bacterial infection. The initial trigger for this reaction is the recognition of the pathogens by antigen presenting cells, such as macrophages and dendritic cells, whose actions can be influenced by leptin. This review aims to present the relationship between leptin, dendritic cells and macrophages in the context of periodontal disease. Thus, we have assembled the most important findings related to leptin’s role in the modulation of the immune response carried out by these cells in periodontitis.

scholarly journals Alleviation Effects of GQD, a Traditional Chinese Medicine Formula, on Diabetes Rats Linked to Modulation of the Gut Microbiome

2021 ◽  
Vol 11 ◽  
Author(s):  
Jiaxing Tian ◽  
Bingbing Bai ◽  
Zezheng Gao ◽  
Yingying Yang ◽  
Haoran Wu ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Gut Microbiota ◽  
Protective Effect ◽  
Intestinal Permeability ◽  
Barrier Function ◽  
Pathogenic Bacteria ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Rrna Gene ◽  
Islet Function

Gegen Qinlian Decoction (GQD) is a Chinese herbal medicine that has been reported to significantly decrease blood glucose levels, which is suggested to be related to interactions with the gut microbiota. However, the protective effect of GQD on intestinal barrier function with regard to its influence on the gut microbiota has not been explored to date. In this study, we investigated the role of the gut microbiota in mediating the hypoglycemic mechanism of GQD in type 2 diabetes mellitus (T2DM) rats induced by a single intraperitoneal injection of streptozotocin after 4 weeks of high-fat diet feeding. The T2DM rats were randomly allocated to receive GQD, metformin (Met), or saline for 12 consecutive weeks, and changes in metabolic parameters, intestinal barrier function, and inflammation were investigated. Gut microbiota was analyzed using 16S rRNA gene sequencing from fecal samples, and statistical analyses were performed to correlate microbiota composition with phenotypes of the T2DM rats. GQD administration decreased the levels of blood glucose and inflammatory cytokines, and increased the levels of tight junction proteins. Besides, GQD had a protective effect on islet function, restoring intestinal permeability, and inhibiting inflammation, as evidenced by increases in the levels of serum C-peptide, occludin, and claudin-1 in the colon, and also improved the expression of serum inflammatory factors. In addition, GQD regulated the structure of the gut microbiota by increasing the proportions of short-chain fatty acids-producing and anti-inflammatory bacteria, and decreasing the proportions of conditioned pathogenic bacteria associated with the diabetic phenotype. Overall, these findings suggest that GQD could ameliorate hyperglycemia and protect islet function by regulating the structure of the gut microbiota, thereby restoring intestinal permeability and inhibiting inflammation in T2DM rats. Our study thus suggests that the hypoglycemic mechanism of GQD is mediated by its modulation of the gut microbiota.

scholarly journals Effect Long-Term Exposure to Different Doses of Lipopolysaccharides on the Intestinal Mucosal Immune Barrier

2019 ◽  
Author(s):  
Chao Li ◽  
Baoyu Zhao ◽  
Chenchen Wu
Keyword(s):  
Layer Thickness ◽  
Goblet Cells ◽  
The Body ◽  
Low Grade ◽  
Low Doses ◽  
Mucus Layer ◽  
High Doses ◽  
Low Grade Inflammation ◽  
Different Doses

The small intestinal villus is covered with a thick layer of mucus that is secreted by goblet cells and functions primarily to first barrier from damage by toxic substance. Recent studies showed that goblet cells and mucins involved in complex immune function. Lipopolysaccharide (LPS) is widespread in the housing of livestock, which can induce bacterial infection symptoms and immunological stress within a short of time. Therefore, we aimed to study the effects of long-term exposure to different doses of LPS on intestinal mucus layer and immune barrier. The result showed that mucus layer thickness and goblet cell functions were significantly increased after low doses of LPS. The intestinal mucosal barrier can block the bacteria of the lumen, but LPS can penetrate this barrier into the blood, putting the body in a state of chronic low-grade inflammation and reducing the body&rsquo;s immune function. However, after long-term exposure to high doses of LPS, a large number of lysosomes in goblet cells caused loss of function, and mucus layer thickness was significantly decreased. A large amount of LPS stuck to the mucus, leading to normal LPS and inflammatory cytokines level of plasma. The intestinal tissue morphology was damaged, and a number of immune cells were necrosis in the intestine. Collectively, long-term exposure to low doses of LPS lead to chronic low-grade inflammation in the body. Long-term exposure to high doses of LPS can be directly linked to the severity of the immunosuppression in the body.

Respose of Cultured Nasal Epithelial Cells to Wall Shear Stress

2007 ◽  
Author(s):  
Nurit Even-Tzur ◽  
Uri Zaretsky ◽  
Michael Wolf ◽  
David Elad
Keyword(s):  
Shear Stress ◽  
Water Vapor ◽  
Wall Shear Stress ◽  
Mucociliary Clearance ◽  
Goblet Cells ◽  
The Body ◽  
Mucus Layer ◽  
Inhaled Particles ◽  
Clearance Mechanism ◽  
Biophysical Changes

The nasal cavity lining is rich with mucus secreting goblet cells. Nasal defense is based on the mucociliary clearance mechanism, in which the secreted mucus layer traps inhaled particles and is constantly driven towards the nasopharynx for removal of the particles from the body. The mucus layer is also important for the exchange of temperature and water vapor with the inspired air. Airway goblet cells discharge mucus in response to a wide variety of biological stimuli, including cytokines, bacterial products, proteinases, oxidants, irritant gases, and inflammatory mediators [1], as well as biophysical changes, such as osmolarity alterations [2].

scholarly journals Immunomodulatory Lectin-like Peptides for Fish Erythrocytes-Targeting as Potential Antiviral Drug Delivery Platforms

2021 ◽  
Vol 22 (21) ◽  
pp. 11821
Author(s):  
Maria Salvador-Mira ◽  
Veronica Chico ◽  
Monica Arostica ◽  
Fanny Guzmán ◽  
Nerea Roher ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Immune Response ◽  
Plasmodium Falciparum ◽  
Rainbow Trout ◽  
Disease Prevention ◽  
Blood Cells ◽  
Antiviral Drug ◽  
The Body ◽  
Antigen Presenting ◽  
Cell Carriers

One of the challenges of science in disease prevention is optimizing drug and vaccine delivery. Until now, many strategies have been employed in this sector, but most are quite complex and labile. To overcome these limitations, great efforts are directed to coupling drugs to carriers, either of natural or synthetic origin. Among the most studied cell carriers are antigen-presenting cells (APCs), however, red blood cells (RBCs) are positioned as attractive carriers in drug delivery due to their abundance and availability in the body. Furthermore, fish RBCs have a nucleus and have been shown to have a strong involvement in modulating the immune response. In this study, we evaluated the binding of three peptides to rainbow trout RBCs, two lectin-like peptides and another derived from Plasmodium falciparum membrane protein, in order to take advantage of this peptide-RBCs binding to generate tools to improve the specificity, efficacy, immunostimulatory effect, and safety of the antiviral therapeutic or prophylactic administration systems currently used.

scholarly journals Association of Heterophil/Lymphocyte Ratio with Intestinal Barrier Function and Immune Response to Salmonella enteritidis Infection in Chicken

Animals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3498
Author(s):  
Mamadou Thiam ◽  
Astrid Lissette Barreto Sánchez ◽  
Jin Zhang ◽  
Maiqing Zheng ◽  
Jie Wen ◽  
...  
Keyword(s):  
Immune Response ◽  
Barrier Function ◽  
Salmonella Enteritidis ◽  
Current Knowledge ◽  
Intestinal Barrier ◽  
Goblet Cells ◽  
Intestinal Barrier Function ◽  
Immune Gene ◽  
Intestinal Immunity ◽  
Ileal Mucosa

The heterophil/lymphocyte (H/L) ratio has been extensively studied to select poultry that are resistant to environmental stressors. Chickens with a low H/L ratio are superior to the chickens with a high H/L ratio in survival, immune response, and resistance to Salmonella infection. However, this disease resistance ability is likely to be associated with enhanced intestinal immunity. Therefore, to expand our understanding of these underlying resistance mechanisms, it is crucial to investigate the correlation between the H/L ratio as a blood immune indicator in live chickens and the intestinal barrier function and immunity. Jinxing yellow chickens H/L line one-day-old were divided into non-infected (NI) and Salmonella enteritidis infected (SI) at 7-days old. After dividing the birds into NI and SI, blood samples were taken for H/L ratios determination, and subsequently, birds from the SI group were infected with Salmonella enteritidis (SE). We assessed the effects of SE infection on the (i) goblet cells number from the ileum and caecum gut-segments, (ii) ileal mucosa morphology, and (iii) immune gene mRNA expressions from the ileum and caecum of NI and SI chickens at 7 and 21 days-post-infection (dpi). We found that the H/L ratio was negatively correlated with most intestinal immune indices, particularly with the goblet cells number and with IL-1β, IL-8, and IFN-γ ileal expressions. In conclusion, these results suggest that the H/L ratio is associated with the intestinal barrier and immune response for SE clearance and that the chickens with a low H/L ratio displayed enhanced intestinal immunity. This study expands the current knowledge that is related to using the H/L ratio to select and breed resistant broiler chickens.

scholarly journals Why the Activities of the Immune System Matter for Social and Personality Psychology (and Not Only for Those Who Study Health)

2019 ◽  
Author(s):  
TCU Hill Lab
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Behavioral Outcomes ◽  
Social Experiences ◽  
The Body ◽  
Personality Psychology ◽  
Important Mediator ◽  
Growing Body ◽  
And Behavior ◽  
The Relationship

A growing body of research finds that the activities of the immune system – in addition to protecting the body from infection and injury – also influence how we think, feel, and behave. Although research on the relationship between the immune system and psychological and behavioral outcomes has most commonly focused on the experiences of those who are ill or experiencing an acute immune response, we propose that the immune system may also play a key role in influencing such outcomes in those who are healthy. Here, we review theory and research suggesting that inflammation – a key component of the immune response to pathogens and stressors – may play an important modulatory role in shaping emotions, motivation, cognition, and behavior, even among those without symptoms of illness. Moreover, because inflammation occurs in response to a number of everyday social experiences (e.g., loneliness, stress), we propose that it may be an important mediator of many psychological and behavioral outcomes that are of interest to social and personality psychologists. We close by discussing potential opportunities for researchers looking to incorporate psychoneuroimmunology (PNI) into their area of inquiry.

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