scholarly journals Reply to Comments on ‘A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus’

2020 ◽  
Vol 40 (2) ◽  
Author(s):  
Bo Huang ◽  
Yu-kun Wang ◽  
Lin-yuan Qin ◽  
Qin Wei ◽  
Nian Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Functional Polymorphism ◽  
Melatonin Receptor ◽  
Melatonin Receptor 1B

Abstract Th authors of ‘A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus’ (Bioscience Reports (2019) 39, 12) have written a reply in response to the correspondence piece by Rosta et al. (Bioscience Reports (2020) 40, 2).

scholarly journals Comments on: A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus

2020 ◽  
Vol 40 (2) ◽  
Author(s):  
Klara Rosta ◽  
Jürgen Harreiter ◽  
Ákos Nádasdi ◽  
László Németh ◽  
Alexandra Kautzky-Willer ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Meta Analysis ◽  
European Ancestry ◽  
Final Conclusion ◽  
Functional Polymorphism ◽  
Melatonin Receptor ◽  
Increased Risk ◽  
Melatonin Receptor 1B

Abstract We have read with great interest the accepted manuscript of the meta-analysis performed by Huang, et al. titled “A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus” published online in the 2019 December 6 issue of Bioscience Reports (https://doi.org/10.1042/BSR20190744). We do agree with the authors’ final conclusion that such a meta-analysis should eventually confirm that the MTNR1B rs10830963 G allele is significantly associated with increased risk of gestational diabetes mellitus (GDM) development in pregnant populations with Asian and European ancestry. However we have surprisingly found that our genetic association study (PLoS One (2017), https://doi.org/10.1371/journal.pone.0169781) was included in this meta-analysis, but with mistakenly calculated odds ratios (OR). Therefore we would suggest to use the correct OR values based on our original publication that were already indicating a high genetic effect size for the MTNR1B rs10830963 risk variant on GDM development.

scholarly journals A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus

2019 ◽  
Vol 39 (12) ◽  
Author(s):  
Bo Huang ◽  
Yu-kun Wang ◽  
Lin-yuan Qin ◽  
Qin Wei ◽  
Nian Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Functional Polymorphism ◽  
Potential Mechanism ◽  
Melatonin Receptor ◽  
Stratified Analysis ◽  
Melatonin Receptor 1B

Abstract The melatonin receptor 1B (MTNR1B) polymorphism rs10830963 C>G has been reported to be associated with the risk of gestational diabetes mellitus (GDM) with inconsistent results. To clarify the effect of the polymorphism on the risk of GDM, a meta-analysis therefore was performed. Pooled OR with its corresponding 95%CI was used to estimate the strength of the association. Totally 14 eligible studies with a number of 5033 GDM patients and 5614 controls were included in this meta-analysis. Results indicated that the variant G allele was significantly associated with an increased GDM risk (CG vs. CC: OR = 1.25, 95% CI = 1.11−1.40, P < 0.001; GG vs. CC: OR = 1.78, 95% CI = 1.45−2.19, P < 0.001; G vs. C: OR = 1.33, 95% CI = 1.21−1.47, P < 0.001). In the stratified analysis by ethnicity, similar results were found in Asians (CG vs. CC: OR = 1.15, 95%CI = 1.02−1.28, P = 0.020; GG vs. CC: OR = 1.52, 95% CI = 1.23−1.89, P < 0.001; G vs. C: OR = 1.23, 95% CI = 1.10−1.37, P < 0.001) and in Caucasians (CG vs. CC: OR = 1.40, 95% CI = 1.16−1.70, P < 0.001; GG vs. CC: OR = 2.21, 95% CI = 1.54−3.17, P < 0.001; G vs. C: OR = 1.47, 95% CI = 1.24−1.73, P < 0.001). FPRP and TSA analyses confirmed findings support that the rs10830963 G allele increases the risk of GDM, and further functional experimental studies are warranted to explore and clarify the potential mechanism.

Association Between a Melatonin Receptor 1B Genetic Polymorphism and Its Protein Expression in Gestational Diabetes Mellitus

2018 ◽  
Vol 26 (10) ◽  
pp. 1382-1388 ◽  
Author(s):  
Chao Li ◽  
Yubin Zhou ◽  
Binglong Qiao ◽  
Lin Xu ◽  
Yan Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Genetic Polymorphism ◽  
Gestational Diabetes ◽  
Protein Expression ◽  
Gestational Diabetes Mellitus ◽  
Chinese Women ◽  
Han Chinese ◽  
Melatonin Receptor ◽  
Melatonin Receptor 1B

Aims: This study was conducted to investigate the relationship between a genetic polymorphism and the expression of melatonin receptor 1B (MTNR1B) in the placenta of Han Chinese women with gestational diabetes mellitus (GDM). Methods: In this study, 215 patients with GDM and 243 healthy controls were genotyped using direct sequencing for the MTNR1B single-nucleotide polymorphism rs10830963. The expression of MTNR1B in placenta was detected by immunohistochemistry and Western blotting. The association of rs10830963 with the expression of MTNR1B, plasma glucose, and insulin levels as well as blood lipid levels was investigated. Results: The genotype and allele frequencies of rs10830963 were significantly different between women with GDM and controls ( P < .05). Fasting blood glucose, fasting insulin, and homeostasis model assessment for insulin resistance in women with GDM with the GG and GC genotypes were significantly higher than those with the CC genotype ( P < .05). The expression level of MTNR1B in placenta was significantly higher in the GDM group than in the control group ( P < .05). The expression of MTNR1B was significantly higher in all participants with the GG and GC genotypes (1.31 [0.74]) than in pregnant women with the CC genotype (0.92 [0.52], P < .05). Conclusions: The genetic polymorphism rs10830963 in MTNR1B and its protein expression levels in placenta are associated with an increased risk of developing GDM. Furthermore, rs10830963 may tag a molecular mechanism leading to insulin resistance in Han Chinese women with GDM.

scholarly journals Association between a functional polymorphism rs10830963 in melatonin receptor 1B and risk of gestational diabetes mellitus: an updated meta-analysis

2017 ◽  
Author(s):  
Yu Xiangyuan ◽  
Wang Qianqian ◽  
Qin Linyuan ◽  
Peng Lingxiang ◽  
Chen Zaiming ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Melatonin Receptor ◽  
Increased Risk ◽  
Stratified Analysis ◽  
Melatonin Receptor 1B

AbstractThe melatonin receptor 1B (MTNR1B) as a candidate gene for gestational diabetes mellitus (GDM) on the basis of its association with T2DM, β-cells function and fasting plasma glucose (FPG) level. Many studies have investigated the association between MTNR1B polymorphism rs10830963 C>G and GDM risk, but the conclusion is inconsistent. PubMed, Google Scholar and CNKI databases were searched to identify eligible studies. Pooled OR with corresponding 95% CI was used to estimate the strength of the association between rs10830963 and GDM risk using a fixed- or random-effect model. 12 eligible studies with a number of 4,782 GDM patients and 5,605 controls were included in this meta-analysis. Results indicated that the variant G allele of rs10830963 polymorphism was significantly associated with an increased risk of GDM (CG vs. CC: OR=1.23, 95% CI = 1.12–1.34, Pheterogeneity = 0.23; GG vs. CC: OR=1.74, 95% CI =1.41–2.15, Pheterogeneity = 0.002). In the stratified analysis by ethnicity, similar results were found in Asians (CG vs. CC: OR=1.15, 95% CI = 1.04–1.28, Pheterogeneity = 0.74; GG VS. CC: OR=1.48, 95% CI =1.23–1.78, Pheterogeneity = 0.08) and in Caucasians (CG vs. CC: OR=1.49, 95% CI =1.25–1.77, Pheterogeneity = 0.28; GG vs. CC: OR=2.68, 95% CI =2.03–3.54, Pheterogeneity = 0.58).

scholarly journals Melatonin receptor 1 B polymorphisms associated with the risk of gestational diabetes mellitus

2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Jason Y Kim ◽  
Hyun Sub Cheong ◽  
Byung-Lae Park ◽  
Sei Hyun Baik ◽  
Sunmin Park ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Melatonin Receptor

The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population

HORMONES ◽  
2012 ◽  
Vol 11 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Margarita Vlassi ◽  
Maria Gazouli ◽  
George Paltoglou ◽  
Panagiotis Christopoulos ◽  
Lina Florentin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Greek Population ◽  
Melatonin Receptor ◽  
Increased Risk

Effects of MTNR1B Genetic Variants on Individual Susceptibility to Gestational Diabetes Mellitus: A Meta-Analysis

2019 ◽  
Vol 37 (06) ◽  
pp. 607-612 ◽  
Author(s):  
Guangliang Jia ◽  
Yanxiang Gao ◽  
Chunzhi Li ◽  
Yanqin Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Meta Analysis ◽  
Recessive Model ◽  
Dominant Model ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Melatonin Receptor 1B ◽  
Allele Model

Abstract Objective Whether melatonin receptor 1B (MTNR1B) variants are implicated in gestational diabetes mellitus (GDM) remains unclear. Therefore, we performed this meta-analysis to obtain a more conclusive result on associations between MTNR1B variants and GDM. Study Design Literature research was performed in PubMed, Web of Science, Embase, and China National Knowledge Infrastructure. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results A total of 17 studies were eligible for analyses. Pooled overall analyses showed that rs1387153 (dominant model: p = 0.0002, OR = 0.78, 95% CI: 0.68–0.89; recessive model: p < 0.0001, OR = 1.46, 95% CI: 1.24–1.73; allele model: p < 0.0001, OR = 0.78, 95% CI: 0.72–0.84), rs4753426 (recessive model: p = 0.01, OR = 1.75, 95% CI: 1.14–2.68; allele model: p = 0.01, OR = 0.69, 95% CI: 0.51–0.93), and rs10830963 (dominant model: p < 0.0001, OR = 0.72, 95% CI: 0.65–0.78; recessive model: p < 0.0001, OR = 1.56, 95% CI: 1.40–1.74; allele model: p < 0.0001, OR = 0.73, 95% CI: 0.69–0.78) variants were all significantly associated with the susceptibility to GDM. Further subgroup analyses by ethnicity of participants yielded similar positive results. Conclusion Our findings indicated that MTNR1B rs1387153, rs4753426, and rs10830963 variants might serve as genetic biomarkers of GDM.

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