scholarly journals Relationship between melatonin receptor 1B and insulin receptor substrate 1 polymorphisms with gestational diabetes mellitus: a systematic review and meta-analysis

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Yan Zhang ◽  
Cheng-Ming Sun ◽  
Xiang-Qin Hu ◽  
Yue Zhao
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Insulin Receptor ◽  
Meta Analysis ◽  
Insulin Receptor Substrate ◽  
Melatonin Receptor ◽  
Insulin Receptor Substrate 1 ◽  
Melatonin Receptor 1B

The Association between Maternal/Fetal Insulin Receptor Substrate 1 Gene Polymorphism rs1801278 and Gestational Diabetes Mellitus in a Chinese Population

2021 ◽  
pp. 1-8
Author(s):  
Lingling Wu ◽  
Changping Fang ◽  
Jun Zhang ◽  
Yanchou Ye ◽  
Haiyan Zhao
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gene Polymorphism ◽  
Gestational Diabetes Mellitus ◽  
Insulin Receptor ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Insulin Receptor Substrate ◽  
Single Center ◽  
Insulin Receptor Substrate 1

<b><i>Objectives:</i></b> Insulin receptor substrate 1 (IRS1) is a crucial factor in the insulin signaling pathway. IRS1 gene polymorphism rs1801278 in mothers has been reported to be associated with gestational diabetes mellitus (GDM). However, it is not clear whether IRS1 gene polymorphism rs1801278 in fetuses is associated with their mothers’ GDM morbidity. The purpose of this study is to analyze the association between maternal, fetal, or maternal/fetal <i>IRS1</i> gene polymorphism rs1801278 and GDM risk. <b><i>Design:</i></b> The study was a single-center, prospective cohort study. In total, 213 pairs of GDM mothers/fetuses and 191 pairs of control mothers/fetuses were included in this study. They were recruited after they underwent oral glucose tolerance test during 24–28 weeks of gestation and followed up until delivery. All participants received the conventional interventions (diet and exercise), and no special therapy except routine treatment. <b><i>Methods:</i></b> A total of 213 pairs of GDM mothers/fetuses and 191 pairs of normal blood glucose pregnant mothers/fetuses were ge­notyped using PCR and DNA sequencing from January 2015 to September 2016. Maternal/fetal <i>IRS1</i> gene polymorphism rs1801278 was analyzed and compared between 2 groups. <b><i>Results:</i></b> There were no significant differences in the frequency of individual mothers’ or fetuses’ <i>IRS1</i> rs1801278 polymorphisms between 2 groups; if both the mothers and fetuses carried A allele, significantly lower GDM morbidity was observed in the mothers. <b><i>Limitations:</i></b> The sample size was relatively small as a single-center study. <b><i>Conclusions:</i></b> Our study suggested that maternal/fetal rs1801278 polymorphism of <i>IRS1</i> is a modulating factor in GDM; both mothers/fetuses carrying the A allele of rs1801278 may protect the mothers against the development of GDM.

scholarly journals Comments on: A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus

2020 ◽  
Vol 40 (2) ◽  
Author(s):  
Klara Rosta ◽  
Jürgen Harreiter ◽  
Ákos Nádasdi ◽  
László Németh ◽  
Alexandra Kautzky-Willer ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Meta Analysis ◽  
European Ancestry ◽  
Final Conclusion ◽  
Functional Polymorphism ◽  
Melatonin Receptor ◽  
Increased Risk ◽  
Melatonin Receptor 1B

Abstract We have read with great interest the accepted manuscript of the meta-analysis performed by Huang, et al. titled “A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus” published online in the 2019 December 6 issue of Bioscience Reports (https://doi.org/10.1042/BSR20190744). We do agree with the authors’ final conclusion that such a meta-analysis should eventually confirm that the MTNR1B rs10830963 G allele is significantly associated with increased risk of gestational diabetes mellitus (GDM) development in pregnant populations with Asian and European ancestry. However we have surprisingly found that our genetic association study (PLoS One (2017), https://doi.org/10.1371/journal.pone.0169781) was included in this meta-analysis, but with mistakenly calculated odds ratios (OR). Therefore we would suggest to use the correct OR values based on our original publication that were already indicating a high genetic effect size for the MTNR1B rs10830963 risk variant on GDM development.

scholarly journals Insulin Receptor Substrate-1 (IRS-1) Gly927Arg: Correlation with Gestational Diabetes Mellitus in Saudi Women

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Khalid Khalaf Alharbi ◽  
Imran Ali Khan ◽  
Zeinab Abotalib ◽  
Malak Mohammed Al-Hakeem
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Insulin Receptor ◽  
Critical Role ◽  
Insulin Receptor Substrate ◽  
Insulin Receptor Substrate 1 ◽  
Female Population ◽  
Women Subjects ◽  
Saudi Women

Pregnant women with gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share a common pathophysiology associated with similar risk factors. Genetic variants used to determine the risk of developing T2DM might also be associated with the prevalence of GDM. The aim of the present study was to scrutinize the relationship between the G972R polymorphism of the insulin receptor substrate-1 (IRS-1) gene with GDM in the Saudi female population. This is a case-control study that monitored 500 Saudi women. Subjects with GDM (n=200) were compared with non-GDM (n=300) controls. We opted to evaluate rs1801278 polymorphism in the IRS1 gene, which plays a critical role in the insulin-signaling pathway. Genotyping was performed with the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. The frequency of the rs1801278 polymorphism was significantly higher in women with GDM than in women with non-GDM (for TT + CT versus CC:P=0.02). Additionally, there was a significant increase in the frequency of the Arg-encoding mutant allele from GDM to non-GDM (for T versus C:P=0.01). Our results suggest that the rs1801278 polymorphism in theIRS-1gene is involved in the occurrence of GDM in the Saudi population.

scholarly journals Association between a functional polymorphism rs10830963 in melatonin receptor 1B and risk of gestational diabetes mellitus: an updated meta-analysis

2017 ◽  
Author(s):  
Yu Xiangyuan ◽  
Wang Qianqian ◽  
Qin Linyuan ◽  
Peng Lingxiang ◽  
Chen Zaiming ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Melatonin Receptor ◽  
Increased Risk ◽  
Stratified Analysis ◽  
Melatonin Receptor 1B

AbstractThe melatonin receptor 1B (MTNR1B) as a candidate gene for gestational diabetes mellitus (GDM) on the basis of its association with T2DM, β-cells function and fasting plasma glucose (FPG) level. Many studies have investigated the association between MTNR1B polymorphism rs10830963 C>G and GDM risk, but the conclusion is inconsistent. PubMed, Google Scholar and CNKI databases were searched to identify eligible studies. Pooled OR with corresponding 95% CI was used to estimate the strength of the association between rs10830963 and GDM risk using a fixed- or random-effect model. 12 eligible studies with a number of 4,782 GDM patients and 5,605 controls were included in this meta-analysis. Results indicated that the variant G allele of rs10830963 polymorphism was significantly associated with an increased risk of GDM (CG vs. CC: OR=1.23, 95% CI = 1.12–1.34, Pheterogeneity = 0.23; GG vs. CC: OR=1.74, 95% CI =1.41–2.15, Pheterogeneity = 0.002). In the stratified analysis by ethnicity, similar results were found in Asians (CG vs. CC: OR=1.15, 95% CI = 1.04–1.28, Pheterogeneity = 0.74; GG VS. CC: OR=1.48, 95% CI =1.23–1.78, Pheterogeneity = 0.08) and in Caucasians (CG vs. CC: OR=1.49, 95% CI =1.25–1.77, Pheterogeneity = 0.28; GG vs. CC: OR=2.68, 95% CI =2.03–3.54, Pheterogeneity = 0.58).

scholarly journals A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus

2019 ◽  
Vol 39 (12) ◽  
Author(s):  
Bo Huang ◽  
Yu-kun Wang ◽  
Lin-yuan Qin ◽  
Qin Wei ◽  
Nian Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Functional Polymorphism ◽  
Potential Mechanism ◽  
Melatonin Receptor ◽  
Stratified Analysis ◽  
Melatonin Receptor 1B

Abstract The melatonin receptor 1B (MTNR1B) polymorphism rs10830963 C&gt;G has been reported to be associated with the risk of gestational diabetes mellitus (GDM) with inconsistent results. To clarify the effect of the polymorphism on the risk of GDM, a meta-analysis therefore was performed. Pooled OR with its corresponding 95%CI was used to estimate the strength of the association. Totally 14 eligible studies with a number of 5033 GDM patients and 5614 controls were included in this meta-analysis. Results indicated that the variant G allele was significantly associated with an increased GDM risk (CG vs. CC: OR = 1.25, 95% CI = 1.11−1.40, P &lt; 0.001; GG vs. CC: OR = 1.78, 95% CI = 1.45−2.19, P &lt; 0.001; G vs. C: OR = 1.33, 95% CI = 1.21−1.47, P &lt; 0.001). In the stratified analysis by ethnicity, similar results were found in Asians (CG vs. CC: OR = 1.15, 95%CI = 1.02−1.28, P = 0.020; GG vs. CC: OR = 1.52, 95% CI = 1.23−1.89, P &lt; 0.001; G vs. C: OR = 1.23, 95% CI = 1.10−1.37, P &lt; 0.001) and in Caucasians (CG vs. CC: OR = 1.40, 95% CI = 1.16−1.70, P &lt; 0.001; GG vs. CC: OR = 2.21, 95% CI = 1.54−3.17, P &lt; 0.001; G vs. C: OR = 1.47, 95% CI = 1.24−1.73, P &lt; 0.001). FPRP and TSA analyses confirmed findings support that the rs10830963 G allele increases the risk of GDM, and further functional experimental studies are warranted to explore and clarify the potential mechanism.

Interpregnancy Weight Change and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

2019 ◽  
Author(s):  
Jose Alberto Martínez-Hortelano ◽  
Ivan Cavero Redondo ◽  
Celia Alvarez ◽  
Ana Díez-Fernández ◽  
Montserrat Hernández-Luengo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Weight Change ◽  
Meta Analysis

scholarly journals A systematic review and meta-analysis of gestational diabetes mellitus and mental health among BAME populations

2021 ◽  
Vol 38 ◽  
pp. 101016
Author(s):  
Gayathri Delanerolle ◽  
Peter Phiri ◽  
Yutian Zeng ◽  
Kathleen Marston ◽  
Nicola Tempest ◽  
...  
Keyword(s):  
Mental Health ◽  
Diabetes Mellitus ◽  
Systematic Review ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Meta Analysis
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