scholarly journals HEY1 functions are regulated by its phosphorylation at Ser-68

2016 ◽  
Vol 36 (3) ◽  
Author(s):  
Irene López-Mateo ◽  
Amaia Arruabarrena-Aristorena ◽  
Cristina Artaza-Irigaray ◽  
Juan A. López ◽  
Enrique Calvo ◽  
...  
Keyword(s):  
Biological Function ◽  
Tumour Suppressor ◽  
Bhlh Domain ◽  
Threonine Kinases

HEY1-dependent activation of the p53 tumour suppressor pathway can be inhibited through direct phosphorylation of HEY1 at Ser-68 located in the bHLH domain. STK38 and STK38L serine/threonine kinases can phosphorylate HEY1 Ser-68 and could modulate its biological function.

scholarly journals The clinical significance and biological function of large tumour suppressor 2 in hepatocellular carcinoma

2017 ◽  
Vol 50 (3) ◽  
pp. e12340 ◽  
Author(s):  
Rong Liang ◽  
Yan Lin ◽  
Chun-Ling Yuan ◽  
Zhi-Hui Liu ◽  
Yong-Qiang Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Biological Function ◽  
Tumour Suppressor ◽  
Large Tumour

tumour suppressor gene and the tobacco industry

The Lancet ◽  
2005 ◽  
Vol 365 (9464) ◽  
pp. 1026-1027
Author(s):  
A BITTON ◽  
M NEUMAN ◽  
J BARNOYA ◽  
S GLANTZ
Keyword(s):  
Tobacco Industry ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor

Sobre el concepto de función en biología. Historia y problemas recientes

2010 ◽  
Vol 16 ◽  
Author(s):  
Andrés L. Jaume
Keyword(s):  
Biological Function ◽  
Mechanistic Explanation ◽  
Functional Explanation ◽  
Function Concept ◽  
Philosophical Thinking ◽  
Systemic Theory ◽  
Points Of View

RESUMENEl presente artículo analiza las diferentes teorías que sobre el concepto de función se han vertido en los últimos cuarenta años y sus problemas. Respecto de los dos grandes enfoques (histórico-etiológico y sistémico) se sostiene que el primero, pese a su hegemonía histórica, presenta considerables dificultades y que la reflexión actual se centra cada vez más en la perspectiva sistémica. Esta última puede enfrentarse mejor a los diversos problemas que genera el concepto de función biológica y es siempre preferible.PALABRAS CLAVEFUNCIÓN BIOLÓGICA, FUNCIÓN SISTéMICA, EXPLICACIÓN FUNCIONAL, EXPLICACIÓN BASADA EN MECANISMOS, TELEOLOGíAABSTRACTThis paper analyzes the different theories on biological function and the problems they brought up over the last forty years. Concerning the two most important points of view on functions (aetiological theory and systemic theory) I hold that the aetiological theory, despite its historical hegemony, presents substantial difficulties and that the present philosophical thinking is centred on systemic theories. Systemic theories are capable of solving the various problems generated by the biological function concept which is preferable.KEYWORDSBIOLOGICAL FUNCTION, SySTEMIC FUNCTION, FUNCTIONAL EXPLANATION, MECHANISTIC EXPLANATION TELEOLOGY

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