scholarly journals The clinical significance and biological function of large tumour suppressor 2 in hepatocellular carcinoma

2017 ◽  
Vol 50 (3) ◽  
pp. e12340 ◽  
Author(s):  
Rong Liang ◽  
Yan Lin ◽  
Chun-Ling Yuan ◽  
Zhi-Hui Liu ◽  
Yong-Qiang Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Biological Function ◽  
Tumour Suppressor ◽  
Large Tumour

LncRNA DCST1-AS1 functions as a competing endogenous RNA to regulate FAIM2 expression by sponging miR-1254 in hepatocellular carcinoma

2019 ◽  
Vol 133 (2) ◽  
pp. 367-379 ◽  
Author(s):  
Jing Chen ◽  
Di Wu ◽  
Yue Zhang ◽  
Yong Yang ◽  
Yunfei Duan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Biological Function ◽  
The Cancer Genome Atlas ◽  
Cycle Arrest ◽  
Cancer Genome Atlas ◽  
Apoptosis Inhibitor ◽  
Hcc Cells

Abstract Long non-coding RNAs (lncRNAs) play important roles in a variety of tumours; however, their biological function and clinical significance in hepatocellular carcinoma (HCC) are still unclear. In the present study, the clinical significance, biological function and regulatory mechanisms of lncRNA DCST1-AS1 in HCC were investigated. Differential lncRNAs in HCC were identified based on The Cancer Genome Atlas (TCGA) database. The biological function and mechanism of DCST1-AS1 were studied in vitro and in vivo. LncRNA DCST1-AS1 was highly expressed in HCC tissues, and the high expression of DCST1-AS1 was significantly correlated with larger tumours and shorter survival time. Moreover, DCST1-AS1 knockout significantly inhibited proliferation, promoted apoptosis and cycle arrest of HCC cells, and inhibited tumour growth in vivo. According to functional analysis, DCST1-AS1 competitively bound miR-1254, thus blocking the silencing effect of miR-1254 on the target gene Fas apoptosis inhibitor 2 (FAIM2). A novel lncRNA DCST1-AS1 that functions as an oncogene in HCC was discovered. DCST1-AS1 up-regulates the expression of FAIM2 by up-regulating the expression of miR-1254, ultimately promoting the proliferation of HCC cells. This research provides new therapeutic targets for HCC.

scholarly journals Expression and Clinical Significance of Large Tumour Suppressor Kinase 2 (LATS2) Gene in Acute Myeloid Leukaemia: An Egyptian Study

2020 ◽  
Author(s):  
Shereen Mohamed El-Hoseiny ◽  
Raafat Mohamed Abd El Fattah ◽  
Rehab Muhammad Abdelkareem ◽  
Doaa Sayed Saleh Sayed ◽  
Thoraya Aly ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Clinical Significance ◽  
Tumour Suppressor ◽  
Large Tumour ◽  
Acute Myeloid

SLC38A4 functions as a tumour suppressor in hepatocellular carcinoma through modulating Wnt/β-catenin/MYC/HMGCS2 axis

2021 ◽  
Author(s):  
Jie Li ◽  
Ming-han Li ◽  
Tian-tian Wang ◽  
Xiao-ning Liu ◽  
Xiao-ting Zhu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumour Suppressor

Long non‐coding RNAs (CASC2 and TUG1) in hepatocellular carcinoma: Clinical significance

2019 ◽  
Vol 21 (9) ◽  
Author(s):  
Noha S. Refai ◽  
Manal L. Louka ◽  
Hany Y. Halim ◽  
Iman Montasser
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Non Coding Rnas

scholarly journals Clinical Significance of Polymorphisms in Immune Response Genes in Hepatitis C-Related Hepatocellular Carcinoma

2019 ◽  
Vol 10 ◽  
Author(s):  
Valli De Re ◽  
Maria Lina Tornesello ◽  
Mariangela De Zorzi ◽  
Laura Caggiari ◽  
Francesca Pezzuto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
Hepatitis C ◽  
Clinical Significance ◽  
Immune Response Genes
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