Motor proteins of the kinesin superfamily: structure and mechanism

2000 ◽  
Vol 35 ◽  
pp. 61-73 ◽  
Author(s):  
F. Jon Kull
Keyword(s):  
Motor Proteins ◽  
Kinesin Superfamily

The Presence of Kinesin Superfamily Motor Proteins KIFC1 and KIF17 in Normal and Pathological Human Placenta

Placenta ◽  
2009 ◽  
Vol 30 (10) ◽  
pp. 848-854 ◽  
Author(s):  
L. Sati ◽  
Y. Seval-Celik ◽  
G. Unek ◽  
E.T. Korgun ◽  
R. Demir
Keyword(s):  
Human Placenta ◽  
Motor Proteins ◽  
Kinesin Superfamily

Intracellular Transport and Kinesin Superfamily Proteins, KIFs: Structure, Function, and Dynamics

2008 ◽  
Vol 88 (3) ◽  
pp. 1089-1118 ◽  
Author(s):  
Nobutaka Hirokawa ◽  
Yasuko Noda
Keyword(s):  
Cell Biology ◽  
Intracellular Transport ◽  
Structural Changes ◽  
Motor Proteins ◽  
Protein Complexes ◽  
Molecular Genetic ◽  
Adaptor Protein ◽  
Binding Activity ◽  
Brain Functions ◽  
Kinesin Superfamily

Various molecular cell biology and molecular genetic approaches have indicated significant roles for kinesin superfamily proteins (KIFs) in intracellular transport and have shown that they are critical for cellular morphogenesis, functioning, and survival. KIFs not only transport various membrane organelles, protein complexes, and mRNAs for the maintenance of basic cellular activity, but also play significant roles for various mechanisms fundamental for life, such as brain wiring, higher brain functions such as memory and learning and activity-dependent neuronal survival during brain development, and for the determination of important developmental processes such as left-right asymmetry formation and suppression of tumorigenesis. Accumulating data have revealed a molecular mechanism of cargo recognition involving scaffolding or adaptor protein complexes. Intramolecular folding and phosphorylation also regulate the binding activity of motor proteins. New techniques using molecular biophysics, cryoelectron microscopy, and X-ray crystallography have detected structural changes in motor proteins, synchronized with ATP hydrolysis cycles, leading to the development of independent models of monomer and dimer motors for processive movement along microtubules.

Kinesin superfamily motor proteins and intracellular transport

2009 ◽  
Vol 10 (10) ◽  
pp. 682-696 ◽  
Author(s):  
Nobutaka Hirokawa ◽  
Yasuko Noda ◽  
Yosuke Tanaka ◽  
Shinsuke Niwa
Keyword(s):  
Intracellular Transport ◽  
Motor Proteins ◽  
Kinesin Superfamily

scholarly journals Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer’s Disease

2017 ◽  
Vol 60 (4) ◽  
pp. 1511-1524 ◽  
Author(s):  
Kelly Hares ◽  
James Scott Miners ◽  
Amelia Jane Cook ◽  
Claire Rice ◽  
Neil Scolding ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Motor Proteins ◽  
Kinesin Superfamily

scholarly journals Kinesin-related proteins in the mammalian testes: candidate motors for meiosis and morphogenesis.

1996 ◽  
Vol 7 (2) ◽  
pp. 289-305 ◽  
Author(s):  
A O Sperry ◽  
L P Zhao
Keyword(s):  
Cell Division ◽  
Molecular Motors ◽  
Motor Proteins ◽  
Sequence Similarity ◽  
Tail Domain ◽  
Mitotic Apparatus ◽  
New Members ◽  
Mitotic Motors ◽  
Kinesin Superfamily ◽  
Related Proteins

The kinesin superfamily of molecular motors comprises proteins that participate in a wide variety of motile events within the cell. Members of this family share a highly homologous head domain responsible for force generation attached to a divergent tail domain thought to couple the motor domain to its target cargo. Many kinesin-related proteins (KRPs) participate in spindle morphogenesis and chromosome movement in cell division. Genetic analysis of mitotic KRPs in yeast and Drosophila, as well as biochemical experiments in other species, have suggested models for the function of KRPs in cell division, including both mitosis and meiosis. Although many mitotic KRPs have been identified, the relationship between mitotic motors and meiotic function is not clearly understood. We have used sequence similarity between mitotic KRPs to identify candidates for meiotic and/or mitotic motors in a vertebrate. We have identified a group of kinesin-related proteins from rat testes (termed here testes KRP1 through KRP6) that includes new members of the bimC and KIF2 subfamilies as well as proteins that may define new kinesin subfamilies. Five of the six testes KRPs identified are expressed primarily in testes. Three of these are expressed in a region of the seminiferous epithelia (SE) rich in meiotically active cells. Further characterization of one of these KRPs, KRP2, showed it to be a promising candidate for a motor in meiosis: it is localized to a meiotically active region of the SE and is homologous to motor proteins associated with the mitotic apparatus. Testes-specific genes provide the necessary probes to investigate whether the motor proteins that function in mammalian meiosis overlap with those of mitosis and whether motor proteins exist with functions unique to meiosis. Our search for meiotic motors in a vertebrate testes has successfully identified proteins with properties consistent with those of meiotic motors in addition to uncovering proteins that may function in other unique motile events of the SE.

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