scholarly journals Refeeding meal-fed rats increases lipoprotein lipase activity and deposition of dietary [14C]lipid in white adipose tissue and decreases oxidation to 14CO2. The role of undernutrition

1992 ◽  
Vol 285 (3) ◽  
pp. 773-778 ◽  
Author(s):  
M L Cruz ◽  
D H Williamson
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Lipoprotein Lipase Activity ◽  
Adipose Tissue Depots ◽  
Ad Libitum ◽  
Subcutaneous Adipose ◽  
Perfused Hearts

Meal-fed (3 h) rats had a decreased food intake, body weight and carcass fat compared with rats fed ad libitum. On refeeding a chow meal containing [1-14C]triolein, the production of 14CO2 was lower (45%) and the accumulation of carcass [14C]lipid higher (37%) in the meal-fed rats. There was higher lipoprotein lipase activity and greater accumulation of [14C]lipid in the epididymal and subcutaneous adipose-tissue depots of the meal-fed rats. In contrast, heparin-releasable lipoprotein lipase was not increased in perfused hearts of meal-fed rats on refeeding. Return of meal-fed rats to feeding ad libitum reversed these changes before the restoration of body weight or carcass fat. Evidence is presented that decreased dietary intake rather than meal pattern is an important determinant of the alterations in adipose lipid metabolism in the meal-fed rat in response to a meal.

Seasonal Variation of Lipoprotein Lipase Activity in Human Subcutaneous Adipose Tissue

1974 ◽  
Vol 47 (6) ◽  
pp. 631-634
Author(s):  
B. Persson
Keyword(s):  
Adipose Tissue ◽  
Seasonal Variation ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Subcutaneous Adipose Tissue ◽  
Blood Glucose Concentration ◽  
Serum Triglyceride ◽  
Lipoprotein Lipase Activity ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Subcutaneous Adipose

1. In 126 normotriglyceridaemic and in seventy-three hypertriglyceridaemic subjects there was a similar seasonal variation of adipose tissue lipoprotein lipase activity, the lowest activity being noted during the summer months. 2. There was no seasonal variation of the serum triglyceride or free fatty acid concentrations in the normotriglyceridaemic group. 3. In the same group the highest blood acetoacetate concentration was noted in March–April, the lowest in November–December. 4. There was no seasonal variation of the blood glucose concentration for women, but for men the lowest concentration was noted in July–August.

Lipoprotein Lipase and Hormone-Sensitive Lipase Activities in Human Subcutaneous Lipomas: Comparison with Normal Subcutaneous Adipose Tissue

1976 ◽  
Vol 50 (4) ◽  
pp. 315-318
Author(s):  
Y. Giudicelli ◽  
R. Pecquery ◽  
B. Agli ◽  
C. Jamin ◽  
J. Quevauvilliers
Keyword(s):  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Subcutaneous Adipose Tissue ◽  
Normal Subjects ◽  
Hormone Sensitive Lipase ◽  
Lipoprotein Lipase Activity ◽  
Hormone Sensitive ◽  
Subcutaneous Adipose ◽  
Control Samples

1. Lipoprotein lipase activity and hormone-sensitive lipase activity were investigated in subcutaneous lipomas removed from two patients and compared with the enzyme activities in subcutaneous adipose tissue from two normal subjects. 2. Confirmation was obtained of the presence of lipoprotein lipase activity in lipomas with an activity fifteen to forty-five times that in the two control samples. 3. Hormone-sensitive lipase activity was demonstrated in lipomas under basal conditions of assay as well as in the presence of adrenaline plus theophylline. However, compared with the non-lipomatous fat samples, these activities were lower, as was the magnitude of the lipolytic response to adrenaline plus theophylline. 4. The significance of these measurements of enzyme activity and their role in the pathogenesis of lipomas are briefly discussed.

Estradiol-induced changes in lipoprotein lipase, eating, and body weight in rats

1981 ◽  
Vol 240 (5) ◽  
pp. E533-E538 ◽  
Author(s):  
I. Ramirez
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Body Weight Loss ◽  
Estradiol Benzoate ◽  
Ovariectomized Rats ◽  
Lipoprotein Lipase Activity ◽  
Adipose Tissue Lipoprotein Lipase

Daily injections of 5 micrograms estradiol benzoate (EB) for 1, 2, 3, and 12 days decreased parametrial and retroperitoneal adipose tissue lipoprotein lipase activity in ovariectomized rats. Nearly all of this decrease occurred within the 1st day. In contrast, EB-induced body weight loss and hypophagia were very slight during the 1st day after EB administration and increased substantially over the next 2 days. EB did not affect gastrocnemius muscle lipoprotein lipase activity over the first 3 days, but did decrease muscle lipoprotein lipase activity after 12 days. These changes in adipose and muscle lipoprotein lipase activity suggested that EB-induced redistribution of fuel would be greater after 3 days of treatment than after 12 days of treatment. Tests with two different in vivo triglyceride uptake methods confirmed this suggestion. EB-treated rats were hypertriglyceridemic after 12 days of treatment, but not after 3 days of treatment. Elevated plasma triglycerides were associated with an increased rate of triglyceride entry. These findings are consistent with the hypothesis that EB administration temporarily results in redistribution of triglyceride fuel from adipose tissue to muscle, resulting in a transient decrease in rate of weight gain.

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