Lipoprotein Lipase and Hormone-Sensitive Lipase Activities in Human Subcutaneous Lipomas: Comparison with Normal Subcutaneous Adipose Tissue

1976 ◽  
Vol 50 (4) ◽  
pp. 315-318
Author(s):  
Y. Giudicelli ◽  
R. Pecquery ◽  
B. Agli ◽  
C. Jamin ◽  
J. Quevauvilliers
Keyword(s):  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Subcutaneous Adipose Tissue ◽  
Normal Subjects ◽  
Hormone Sensitive Lipase ◽  
Lipoprotein Lipase Activity ◽  
Hormone Sensitive ◽  
Subcutaneous Adipose ◽  
Control Samples

1. Lipoprotein lipase activity and hormone-sensitive lipase activity were investigated in subcutaneous lipomas removed from two patients and compared with the enzyme activities in subcutaneous adipose tissue from two normal subjects. 2. Confirmation was obtained of the presence of lipoprotein lipase activity in lipomas with an activity fifteen to forty-five times that in the two control samples. 3. Hormone-sensitive lipase activity was demonstrated in lipomas under basal conditions of assay as well as in the presence of adrenaline plus theophylline. However, compared with the non-lipomatous fat samples, these activities were lower, as was the magnitude of the lipolytic response to adrenaline plus theophylline. 4. The significance of these measurements of enzyme activity and their role in the pathogenesis of lipomas are briefly discussed.

Seasonal Variation of Lipoprotein Lipase Activity in Human Subcutaneous Adipose Tissue

1974 ◽  
Vol 47 (6) ◽  
pp. 631-634
Author(s):  
B. Persson
Keyword(s):  
Adipose Tissue ◽  
Seasonal Variation ◽  
Lipoprotein Lipase ◽  
Lipase Activity ◽  
Subcutaneous Adipose Tissue ◽  
Blood Glucose Concentration ◽  
Serum Triglyceride ◽  
Lipoprotein Lipase Activity ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Subcutaneous Adipose

1. In 126 normotriglyceridaemic and in seventy-three hypertriglyceridaemic subjects there was a similar seasonal variation of adipose tissue lipoprotein lipase activity, the lowest activity being noted during the summer months. 2. There was no seasonal variation of the serum triglyceride or free fatty acid concentrations in the normotriglyceridaemic group. 3. In the same group the highest blood acetoacetate concentration was noted in March–April, the lowest in November–December. 4. There was no seasonal variation of the blood glucose concentration for women, but for men the lowest concentration was noted in July–August.

scholarly journals Effects of Physiological Hypercortisolemia on the Regulation of Lipolysis in Subcutaneous Adipose Tissue1

1998 ◽  
Vol 83 (2) ◽  
pp. 626-631 ◽  
Author(s):  
Jaswinder S. Samra ◽  
Mo L. Clark ◽  
Sandy M. Humphreys ◽  
Ian A. MacDonald ◽  
Peter A. Bannister ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Sodium Succinate ◽  
Hormone Sensitive Lipase ◽  
Whole Body ◽  
Constant Infusion ◽  
Nonesterified Fatty Acid ◽  
Significant Difference ◽  
Hormone Sensitive ◽  
Subcutaneous Adipose

Cortisol is known to increase whole body lipolysis, yet chronic hypercortisolemia results in increased fat mass. The main aim of the study was to explain these two apparently opposed observations by examining the acute effects of hypercortisolemia on lipolysis in subcutaneous adipose tissue and in the whole body. Six healthy subjects were studied on two occasions. On one occasion hydrocortisone sodium succinate was infused iv to induce hypercortisolemia (mean plasma cortisol concentrations, 1500 ± 100 vs. 335± 25 nmol/L; P < 0.001); on the other occasion (control study) no intervention was made. Lipolysis in the sc adipose tissue of the anterior abdominal wall was studied by measurement of arterio-venous differences, and lipolysis in the whole body was studied by constant infusion of[ 1,2,3-2H5]glycerol for measurement of the systemic glycerol appearance rate. Hypercortisolemia led to significantly increased arterialized plasma nonesterified fatty acid (NEFA; P < 0.01) and blood glycerol concentrations (P < 0.05), with an increase in systemic glycerol appearance (P < 0.05). However, in sc abdominal adipose tissue, hypercortisolemia decreased veno-arterialized differences for NEFA (P < 0.05) and reduced NEFA efflux (P < 0.05). This reduction was attributable to decreased intracellular lipolysis (P < 0.05), reflecting decreased hormone-sensitive lipase action in this adipose depot. Hypercortisolemia caused a reduction in arterialized plasma TAG concentrations (P < 0.05), but without a significant change in the local extraction of TAG (presumed to reflect the action of adipose tissue lipoprotein lipase). There was no significant difference in plasma insulin concentrations between the control and hypercortisolemia study. Site-specific regulation of the enzymes of intracellular lipolysis (hormone-sensitive lipase) and intravascular lipolysis (lipoprotein lipase) may explain the ability of acute cortisol treatment to increase systemic glycerol and NEFA appearance rates while chronically promoting net central fat deposition.

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