scholarly journals A sequence similarity between proteins involved in initiation and termination of bacterial chromosome replication

1991 ◽  
Vol 275 (3) ◽  
pp. 823 ◽  
Author(s):  
A V Kralicek ◽  
A J Day ◽  
R G Wake ◽  
G F King
Keyword(s):  
Sequence Similarity ◽  
Chromosome Replication ◽  
Bacterial Chromosome

scholarly journals Searching for new antibiotics – inhibitors of bacterial chromosome replication

2014 ◽  
Vol 68 ◽  
pp. 701-714 ◽  
Author(s):  
Damian Trojanowski ◽  
Patrycja Skut ◽  
Joanna Hołówka ◽  
Marcin Jan Szafran
Keyword(s):  
Chromosome Replication ◽  
Bacterial Chromosome ◽  
New Antibiotics

scholarly journals Blocking the Trigger: Inhibition of the Initiation of Bacterial Chromosome Replication as an Antimicrobial Strategy

Antibiotics ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 111
Author(s):  
Julia E. Grimwade ◽  
Alan C. Leonard
Keyword(s):  
Drug Targets ◽  
Antimicrobial Agents ◽  
Current Knowledge ◽  
Chromosome Replication ◽  
Bacterial Chromosome ◽  
Resistant Bacteria ◽  
Bacterial Cells ◽  
Drug Resistant Bacteria ◽  
New Antibiotics ◽  
Novel Drug

All bacterial cells must duplicate their genomes prior to dividing into two identical daughter cells. Chromosome replication is triggered when a nucleoprotein complex, termed the orisome, assembles, unwinds the duplex DNA, and recruits the proteins required to establish new replication forks. Obviously, the initiation of chromosome replication is essential to bacterial reproduction, but this process is not inhibited by any of the currently-used antimicrobial agents. Given the urgent need for new antibiotics to combat drug-resistant bacteria, it is logical to evaluate whether or not unexploited bacterial processes, such as orisome assembly, should be more closely examined for sources of novel drug targets. This review will summarize current knowledge about the proteins required for bacterial chromosome initiation, as well as how orisomes assemble and are regulated. Based upon this information, we discuss current efforts and potential strategies and challenges for inhibiting this initiation pharmacologically.

scholarly journals oriC-encoded instructions for the initiation of bacterial chromosome replication

2015 ◽  
Vol 5 ◽  
Author(s):  
Marcin WolaÅ„ski ◽  
RafaÅ‚ Donczew ◽  
Anna Zawilak-Pawlik ◽  
Jolanta Zakrzewska-Czerwińska
Keyword(s):  
Chromosome Replication ◽  
Bacterial Chromosome

Protein–protein interactions in the archaeal core replisome

2011 ◽  
Vol 39 (1) ◽  
pp. 163-168 ◽  
Author(s):  
Stuart A. MacNeill
Keyword(s):  
Protein Interactions ◽  
Current Knowledge ◽  
Sequence Similarity ◽  
Chromosome Replication ◽  
Model System ◽  
Protein Protein Interactions ◽  
Chromosomal Dna ◽  
The Core ◽  
Core Components ◽  
Replication Factors

Most of the core components of the archaeal chromosomal DNA replication apparatus share significant protein sequence similarity with eukaryotic replication factors, making the Archaea an excellent model system for understanding the biology of chromosome replication in eukaryotes. The present review summarizes current knowledge of how the core components of the archaeal chromosome replication apparatus interact with one another to perform their essential functions.

Nalidixic acid and bacterial chromosome replication

Nature ◽  
1976 ◽  
Vol 260 (5552) ◽  
pp. 643-645 ◽  
Author(s):  
G. C. CRUMPLIN ◽  
J. T. SMITH
Keyword(s):  
Nalidixic Acid ◽  
Chromosome Replication ◽  
Bacterial Chromosome

Control of bacterial chromosome replication by non-coding regions outside the origin

2016 ◽  
Vol 63 (4) ◽  
pp. 607-611 ◽  
Author(s):  
Jakob Frimodt-Møller ◽  
Godefroid Charbon ◽  
Anders Løbner-Olesen
Keyword(s):  
Chromosome Replication ◽  
Bacterial Chromosome ◽  
Coding Regions
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