Nalidixic acid and bacterial chromosome replication

Nature ◽  
1976 ◽  
Vol 260 (5552) ◽  
pp. 643-645 ◽  
Author(s):  
G. C. CRUMPLIN ◽  
J. T. SMITH
Keyword(s):  
Nalidixic Acid ◽  
Chromosome Replication ◽  
Bacterial Chromosome

scholarly journals Searching for new antibiotics – inhibitors of bacterial chromosome replication

2014 ◽  
Vol 68 ◽  
pp. 701-714 ◽  
Author(s):  
Damian Trojanowski ◽  
Patrycja Skut ◽  
Joanna Hołówka ◽  
Marcin Jan Szafran
Keyword(s):  
Chromosome Replication ◽  
Bacterial Chromosome ◽  
New Antibiotics

scholarly journals Blocking the Trigger: Inhibition of the Initiation of Bacterial Chromosome Replication as an Antimicrobial Strategy

Antibiotics ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 111
Author(s):  
Julia E. Grimwade ◽  
Alan C. Leonard
Keyword(s):  
Drug Targets ◽  
Antimicrobial Agents ◽  
Current Knowledge ◽  
Chromosome Replication ◽  
Bacterial Chromosome ◽  
Resistant Bacteria ◽  
Bacterial Cells ◽  
Drug Resistant Bacteria ◽  
New Antibiotics ◽  
Novel Drug

All bacterial cells must duplicate their genomes prior to dividing into two identical daughter cells. Chromosome replication is triggered when a nucleoprotein complex, termed the orisome, assembles, unwinds the duplex DNA, and recruits the proteins required to establish new replication forks. Obviously, the initiation of chromosome replication is essential to bacterial reproduction, but this process is not inhibited by any of the currently-used antimicrobial agents. Given the urgent need for new antibiotics to combat drug-resistant bacteria, it is logical to evaluate whether or not unexploited bacterial processes, such as orisome assembly, should be more closely examined for sources of novel drug targets. This review will summarize current knowledge about the proteins required for bacterial chromosome initiation, as well as how orisomes assemble and are regulated. Based upon this information, we discuss current efforts and potential strategies and challenges for inhibiting this initiation pharmacologically.

scholarly journals oriC-encoded instructions for the initiation of bacterial chromosome replication

2015 ◽  
Vol 5 ◽  
Author(s):  
Marcin WolaÅ„ski ◽  
RafaÅ‚ Donczew ◽  
Anna Zawilak-Pawlik ◽  
Jolanta Zakrzewska-Czerwińska
Keyword(s):  
Chromosome Replication ◽  
Bacterial Chromosome
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