scholarly journals Sickle cell membranes and oxidative damage

1986 ◽  
Vol 237 (1) ◽  
pp. 265-269 ◽  
Author(s):  
C Rice-Evans ◽  
S C Omorphos ◽  
E Baysal
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Oxidative Damage ◽  
Sickle Cell ◽  
Iron Chelator ◽  
Oxidation Products ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Sickle Erythrocytes ◽  
Membrane Bound

Sickle erythrocytes and their membranes are susceptible to endogenous free-radical-mediated oxidative damage which correlates with the proportion of irreversibly sickled cells. The suppression of incubation-induced oxidative stress by antioxidants, free radical scavengers and an iron chelator suggest that oxidation products of membrane-bound haemoglobin contribute towards the pathology of the disease.

Changes in lipid peroxidation during pregnancy and after delivery in rats: effect of pinealectomy

Reproduction ◽  
2000 ◽  
pp. 143-149 ◽  
Author(s):  
RM Sainz ◽  
RJ Reiter ◽  
JC Mayo ◽  
J Cabrera ◽  
DX Tan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Oxidative Damage ◽  
Energy Demand ◽  
Physiological State ◽  
High Energy ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Oxygen Requirement ◽  
Pregnant Rats

Pregnancy is a physiological state accompanied by a high energy demand of many bodily functions and an increased oxygen requirement. Because of the increased intake and utilization of oxygen, increased levels of oxidative stress would be expected. In the present study, the degree of lipid peroxidation was examined in different tissues from non-pregnant and pregnant rats after the delivery of their young. Melatonin and other indole metabolites are known to be direct free radical scavengers and indirect antioxidants. Thus the effect of pinealectomy at 1 month before pregnancy on the accumulation of lipid damage was investigated in non-pregnant and pregnant rats after the delivery of their young. Malonaldehyde and 4-hydroxyalkenal concentrations were measured in the lung, uterus, liver, brain, kidney, thymus and spleen from intact and pinealectomized pregnant rats soon after birth of their young and at 14 and 21 days after delivery. The same parameters were also evaluated in intact and pinealectomized non-pregnant rats. Shortly after delivery, lipid oxidative damage was increased in lung, uterus, brain, kidney and thymus of the mothers. No differences were detected in liver and spleen. Pinealectomy enhanced this effect in the uterus and lung. It is concluded that during pregnancy high levels of oxidative stress induce an increase in oxidative damage to lipids, which in some cases is inhibited by the antioxidative actions of pineal indoles.

scholarly journals Molecular Mechanisms behind Free Radical Scavengers Function against Oxidative Stress

Antioxidants ◽  
2017 ◽  
Vol 6 (3) ◽  
pp. 51 ◽  
Author(s):  
Fereshteh Ahmadinejad ◽  
Simon Geir Møller ◽  
Morteza Hashemzadeh-Chaleshtori ◽  
Gholamreza Bidkhori ◽  
Mohammad-Saeid Jami
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Molecular Mechanisms ◽  
Free Radical Scavengers ◽  
Radical Scavengers
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