scholarly journals Competitive binding of adenine and nicotinamide–adenine dinucleotide to diphtheria toxin

1968 ◽  
Vol 107 (5) ◽  
pp. 730-732 ◽  
Author(s):  
Simonetta Sperti ◽  
L. Montanaro
Keyword(s):  
Nicotinamide Adenine Dinucleotide ◽  
Diphtheria Toxin ◽  
Competitive Binding ◽  
Nicotinamide Adenine

Photoaffinity Labeling of Diphtheria Toxin Fragment A with 8-Azidoadenosyl Nicotinamide Adenine Dinucleotide†

Biochemistry ◽  
1999 ◽  
Vol 38 (42) ◽  
pp. 13877-13886 ◽  
Author(s):  
Rita Lodaya ◽  
Steven R. Blanke ◽  
R. John Collier ◽  
James T. Slama
Keyword(s):  
Nicotinamide Adenine Dinucleotide ◽  
Diphtheria Toxin ◽  
Photoaffinity Labeling ◽  
Nicotinamide Adenine

scholarly journals STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN

1964 ◽  
Vol 120 (6) ◽  
pp. 1019-1039 ◽  
Author(s):  
R. J. Collier ◽  
A. M. Pappenheimer
Keyword(s):  
Amino Acids ◽  
Hela Cells ◽  
Nicotinamide Adenine Dinucleotide ◽  
Ribonucleic Acid ◽  
Mode Of Action ◽  
Diphtheria Toxin ◽  
Polypeptide Chain ◽  
Nicotinamide Adenine ◽  
Low Concentrations ◽  
Rabbit Reticulocytes

It has been demonstrated that low concentrations of highly purified diphtheria toxin specifically inhibit incorporation of labeled amino acids into polypeptides in extracts from HeLa cells and from rabbit reticulocytes. No inhibition of incorporation occurs in the absence of a specific cofactor. This cofactor has been identified as nicotinamide adenine dinucleotide (NAD). It has been shown that it is one of the steps involving transfer of amino acids from soluble ribonucleic acid to the growing polypeptide chain that is affected by the toxin in the presence of NAD.

Effect of Niacin on Mitochondria of Allium Cepa Root Cells

1967 ◽  
Vol 25 ◽  
pp. 78-79
Author(s):  
M. Arif Hayat
Keyword(s):  
Nicotinamide Adenine Dinucleotide ◽  
Hydrogen Transfer ◽  
Nicotinamide Adenine Dinucleotide Phosphate ◽  
Nicotinamide Adenine ◽  
Root Tips ◽  
Root Cells ◽  
Transfer Processes ◽  
Standard Procedures ◽  
A Cell ◽  
Critical Interest

Although it is recognized that niacin (pyridine-3-carboxylic acid), incorporated as the amide in nicotinamide adenine dinucleotide (NAD) or in nicotinamide adenine dinucleotide phosphate (NADP), is a cofactor in hydrogen transfer in numerous enzyme reactions in all organisms studied, virtually no information is available on the effect of this vitamin on a cell at the submicroscopic level. Since mitochondria act as sites for many hydrogen transfer processes, the possible response of mitochondria to niacin treatment is, therefore, of critical interest.Onion bulbs were placed on vials filled with double distilled water in the dark at 25°C. After two days the bulbs and newly developed root system were transferred to vials containing 0.1% niacin. Root tips were collected at ¼, ½, 1, 2, 4, and 8 hr. intervals after treatment. The tissues were fixed in glutaraldehyde-OsO4 as well as in 2% KMnO4 according to standard procedures. In both cases, the tissues were dehydrated in an acetone series and embedded in Reynolds' lead citrate for 3-10 minutes.

Nicotinamide Adenine Dinucleotide and the Metabolism of Ethanol and Acetaldehyde

1967 ◽  
Vol 28 (2) ◽  
pp. 213-224 ◽  
Author(s):  
E. Majchrowicz ◽  
B. L. Bercaw ◽  
W. M. Cole ◽  
D. H. Gregory
Keyword(s):  
Nicotinamide Adenine Dinucleotide ◽  
Nicotinamide Adenine
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