scholarly journals Oxidative phosphorylation accompanying oxidation of short-chain fatty acids by rat-liver mitochondria

1966 ◽  
Vol 98 (2) ◽  
pp. 378-388 ◽  
Author(s):  
FJR Hird ◽  
MJ Weidemann
Keyword(s):  
Fatty Acids ◽  
Oxidative Phosphorylation ◽  
Rat Liver ◽  
Short Chain Fatty Acids ◽  
Liver Mitochondria ◽  
Short Chain ◽  
Rat Liver Mitochondria ◽  
Chain Fatty Acids

scholarly journals Effect of pent-4-enoic acid, propionic acid and other short-chain fatty acids on citrulline synthesis in rat liver mitochondria

1976 ◽  
Vol 156 (2) ◽  
pp. 301-307 ◽  
Author(s):  
A M Glasgow ◽  
H P Chase
Keyword(s):  
Fatty Acids ◽  
Propionic Acid ◽  
Rat Liver ◽  
Short Chain Fatty Acids ◽  
Liver Mitochondria ◽  
Short Chain ◽  
Enoic Acid ◽  
Rat Liver Mitochondria ◽  
Carbamoyl Phosphate ◽  
Citrulline Synthesis

19 The effect of pent-4-enoic acid, propionic acid and several other short-chain fatty acids on citrulline synthesis in rat liver mitochondria was studied. 2. Pent-4-enoate at 1 mM inhibited mitochondrial citulline synthesis by about 80-90%. It is concluded that pent-4-enoate inhibits citrulline synthesis by interfering with some aspect of mitochondrial energy metabolism. This results in impairment of mitochondrial ornithine uptake or depletion of mitochondrial ATP, which, in turn, impairs carbamoyl phosphate synthesis or both. Evidence in support of this conclusion includes: pent-4-enoate has no effect on citrulline synthesis supported by succinate or exogenous ATP; pent-4-enoate lowers the medium plus mitochondrial ATP concentration; finally, when glutamate is the oxidizable substrate, pent-4-enoate decreases the carbamoyl phosphate concentration in mitochondria incubated without ornithine to minimize citrulline synthesis and impairs the mitochondrial uptake of ornithine, but it has neither effect when succinate is the oxidizable substrate. 4. Propionate, butyrate and crotonate also inhibit mitochondrial citrulline synthesis, but much less than pent-4-enoate. 5. Acetate, pentanoate, pent-2-enoate, hexanoate, octanoate, isovalerate, tiglylate and α-methylbutyrate have little or no effect on mitochondrial citrulline synthesis.

scholarly journals Effect of polyunsaturated fatty acids deficiency on oxidative phosphorylation in rat liver mitochondria

1996 ◽  
Vol 1276 (3) ◽  
pp. 181-187 ◽  
Author(s):  
Eric M. Fontaine ◽  
Marguerite Moussa ◽  
Anne Devin ◽  
Jésus Garcia ◽  
Jacques Ghisolfi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Oxidative Phosphorylation ◽  
Polyunsaturated Fatty Acids ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria
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