scholarly journals Lysosomal enzyme changes in enforced mammary-gland involution

1965 ◽  
Vol 97 (2) ◽  
pp. 518-522 ◽  
Author(s):  
AL Greenbaum ◽  
TF Slater ◽  
DY Wang
Keyword(s):  
Mammary Gland ◽  
Rapid Decrease ◽  
Mammary Involution ◽  
Mammary Gland Involution ◽  
Reserpine Treatment ◽  
Histological Appearance ◽  
Antihistamine Drug ◽  
Rat Mammary Gland ◽  
Early Phases ◽  
Enzyme Changes

1. Changes occurring in the activities and latency of acid ribonuclease and beta-glucuronidase have been studied in rat mammary gland during the early phases of mammary involution. 2. It was found that there were rapid increases in the proportions of both enzymes in the; free' (i.e. unsedimentable) form. The total activities of both enzymes did not show the rapid decrease characteristic of most other enzymes studied during mammary-gland involution. 3. The effects of pretreating the rats with reserpine or the antihistamine drug Phenergan on these lysosomal changes was studied. Neither treatment affected the enzymic redistribution that occurs during early involution. 4. It was concluded that lysosomal rupture occurs as an early manifestation of mammary-gland involution. Although reserpine treatment preserves the histological appearance of the gland and, apparently, inhibits involution, this drug did not prevent the lysosomal changes normally found in suspensions.

STRUCTURAL CHANGES ASSOCIATED WITH INHIBITION OF INVOLUTION OF THE MAMMARY GLAND IN THE ALBINO RAT

1971 ◽  
Vol 51 (1) ◽  
pp. 137-NP ◽  
Author(s):  
R. C. RICHARDS ◽  
G. K. BENSON
Keyword(s):  
Growth Hormone ◽  
Mammary Gland ◽  
Epithelial Cells ◽  
Structural Changes ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Albino Rat ◽  
Mammary Involution ◽  
Reserpine Treatment

SUMMARY Litters were removed from post-parturient rats on day 4 of lactation and the mothers were then treated with various hormones and pharmacological substances. All treatments (oxytocin, reserpine, prolactin (PR), prolactin+ growth hormone (GH), prolactin + adrenocorticotrophin (ACTH)) resulted in a significant retardation of mammary involution. Both oxytocin and reserpine treatment had little effect on the maintenance of the ultrastructure of the mammary epithelial cells, although after reserpine treatment fat droplets were more frequently observed in the epithelial cells. Treatment with PR, PR + GH and PR + ACTH resulted in a progressive maintenance of the ultrastructure of the epithelial cells, with increased fat present in these cells. However, all treatments failed to alter the distribution of the macrophage-like cells and no alteration in the lysosomes was apparent. The factors involved and the mechanisms by which these treatments might have exerted their effect are discussed.

PITUITARY-ADRENAL RELATIONSHIPS IN THE RETARDATION OF MAMMARY GLAND INVOLUTION BY OXYTOCIN

1960 ◽  
Vol 20 (2) ◽  
pp. 91-NP ◽  
Author(s):  
G. K. BENSON
Keyword(s):  
Mammary Gland ◽  
Concomitant Administration ◽  
Appreciable Effect ◽  
Slight Effect ◽  
Simultaneous Treatment ◽  
Mammary Gland Tissue ◽  
Mammary Involution ◽  
Mammary Gland Involution ◽  
Gland Tissue ◽  
Intact Rats

SUMMARY After adrenalectomy and removal of the pups from rats on the 4th day of lactation, administration of oxytocin for 9 days had little or no effect in inhibiting mammary gland involution. However, simultaneous treatment with 9α-fluorocortisol (FC) resulted in a significant maintenance of mammary gland tissue. Prolactin had an appreciable effect in retarding mammary involution, in the absence of the adrenals, but this effect was not enhanced by concomitant administration of FC, which, given alone, had only a slight effect in adrenalectomized animals. Prolactin and growth hormone (GH) together had a marked synergistic effect. In intact rats only comparatively slight effects on maintenance of the mammary gland were observed following treatment for 9 days with either FC or adrenocorticotrophic hormone (ACTH), and ACTH failed to enhance the action of prolactin and GH. The apparent failure of oxytocin to induce release of prolactin in adrenalectomized rats cannot be explained solely on a metabolic or nutritional basis. It is suggested that either the release of stored prolactin is inhibited in the absence of the adrenals, or that the production of prolactin is adversely affected.

0741 Effect of intrammamary infusion of chitosan hydrogels on bovine mammary gland involution after drying-off

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 355-356
Author(s):  
S. Lanctot ◽  
X. Zhao ◽  
P. Fustier ◽  
A. Taherian ◽  
B. Bisakowski ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Bovine Mammary Gland ◽  
Mammary Gland Involution ◽  
Chitosan Hydrogels
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