scholarly journals Antidotal activity of British anti-lewisite against compounds of antimony, gold and mercury

1947 ◽  
Vol 41 (3) ◽  
pp. 342-346 ◽  
Author(s):  
R. H. S. Thompson ◽  
V. P. Whittaker
Keyword(s):  
Antidotal Activity

scholarly journals Antidotal activity of Averrhoa carambola (Star fruit) on fluoride induced toxicity in rats

2014 ◽  
Vol 7 (2) ◽  
pp. 103-110 ◽  
Author(s):  
Rupal A. Vasant ◽  
A. V. R. L. Narasimhacharya
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Dietary Supplement ◽  
Antioxidant Activities ◽  
Averrhoa Carambola ◽  
Laboratory Rats ◽  
Star Fruit ◽  
Fruit Powder ◽  
And Oxidative Stress ◽  
Antidotal Activity

ABSTRACT Consumption of fluoride leads to several physiological disturbances in carbohydrate, lipid and antioxidant metabolisms. Averrhoa carambola L. fruit (Star fruit) is a commonly consumed fruit in tropical countries and is an ingredient in folklore medicines. As the fruits have high polyphenolic and antioxidant contents, the present study was undertaken to investigate the potential of star fruit as a dietary supplement in attenuating the fluoride induced hyperglycemia, hypercholesterolemia and oxidative stress in laboratory rats. A four-week exposure to fluoride caused sustained hyperglycemia, hyperlipidemia and oxidative stress and, when the diet was supplemented with star fruit powder, carbohydrate, lipid and antioxidant profiles were restored significantly. It is surmised that the antihyperglycemic, antihypercholesterolemic and antioxidant activities of star fruit in fluoride exposed rats could be due to the presence of polyphenols, flavonoids, saponins, phytosterols, ascorbic acid and fibers in the fruit, which are all well known regulators of carbohydrate, lipid and antioxidant metabolisms. These findings suggest that star fruit can be used as a dietary supplement in fluoride endemic regions to contain fluoride induced hyperglycemia, hyperlipidemia and oxidative stress

TEA pretreatment induces significant increasing of pralidoxime antidotal activity

2008 ◽  
Vol 180 ◽  
pp. S168
Author(s):  
Pascal Houzé ◽  
Maya Kayouka ◽  
Patricia Risède ◽  
Frédéric Baud
Keyword(s):  
Antidotal Activity

Acute renal failure enhances the antidotal activity of pralidoxime towards paraoxon-induced respiratory toxicity

2009 ◽  
Vol 189 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Maya Kayouka ◽  
Pascal Houzé ◽  
Marcel Debray ◽  
Frederic J. Baud
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Respiratory Toxicity ◽  
Antidotal Activity

scholarly journals A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning.

2011 ◽  
Vol 58 (2) ◽  
Author(s):  
Jasna Lovrić ◽  
Suzana Berend ◽  
Ana Lucić Vrdoljak ◽  
Božica Radić ◽  
Maja Katalinić ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Organophosphorus Compounds ◽  
Human Lymphocytes ◽  
Human Erythrocytes ◽  
Antidotal Activity

A conjugate of pyridine-4-aldoxime and atropine (ATR-4-OX) was synthesized and its antidotal efficiency was tested in vitro on tabun- or paraoxon-inhibited acetylcholinesterase (AChE) of human erythrocytes as well as in vivo using soman-, tabun- or paraoxon-poisoned mice. Its genotoxic profile was assessed on human lymphocytes in vitro and was found acceptable for further research. ATR-4-OX showed very weak antidotal activity, inadequate for soman or tabun poisoning. Conversely, it was effective against paraoxon poisoning both in vitro and in vivo. All animals treated with 5 % or 25 % LD(50) doses of the new oxime survived after administration of 10.0 or 16.0 LD(50) doses of paraoxon, respectively. Based on the persistence of toxicity symptoms in mice, the atropine moiety had questionable effects in attenuating such symptoms. It appears that ATR-4-OX has a therapeutic effect related to the reactivation of phosphylated AChE, but not to receptor antagonization.

THE EFFICACY OF VARIOUS THIOLS AS ANTIDOTES TO LEWISITE

1950 ◽  
Vol 28e (4) ◽  
pp. 135-142 ◽  
Author(s):  
S. D. Simpson ◽  
L. Young
Keyword(s):  
The Other ◽  
Toxic Action ◽  
A Site ◽  
Antidotal Activity

The following thiols were tested for their effectiveness in counteracting the systemic toxic action of lewisite (β-chlorovinyldichloroarsine) in the rat: 1- and 2-mercaptopropane, 2-mercaptoethanol, 1,2-dimercaptoethane, 1,2- and 1,3-dimercaptopropane, 1,2,3-trimercaptopropane, 1,2-dimercapto-n-butane, 2,3-dimercaptopropanol, 1,3-dimercapto-2-propanol, 2,2′-dimercaptodiethyl ether, 2,2′-dimercaptodiisopropyl ether, and 3,3′-dimercaptodipropyl ether. The toxicity and volatility of these compounds were also studied.The tests of antidotal activity were conducted by applying the thiol to the skin at a site which had been dosed with approximately twice the LD50 of lewisite. Under these conditions the monothiols gave no evidence of antidotal activity whereas all the dithiols and the trithiol studied showed some activity. 2,3-Dimercaptopropanol (BAL) and its isomer, 1,3-dimercapto-2-propanol, were much more effective as antidotes to lewisite than any of the other compounds tested. Not only did 2,3-dimercaptopropanol show a somewhat higher antidotal activity than its isomer, but it was also found to be much less toxic.

scholarly journals An experimental study to evaluate the antidotal activity of Neeli Moola (Indigofera tinctoria) Kalka w.s.r to haematological parameters in Vatsanabha (Aconitum ferox ) induced toxicity

2020 ◽  
Vol 5 (06) ◽  
pp. 98-101
Author(s):  
Sreelakshmi A ◽  
Shrinidhi R ◽  
Sudhakar Bhat ◽  
Sreejith K ◽  
Chaithra S. Hebbar
Keyword(s):  
Hematological Parameters ◽  
Drug Group ◽  
Haematological Parameters ◽  
Albino Rats ◽  
Test Drug ◽  
Test Results ◽  
Wistar Strain ◽  
One Way Anova ◽  
Indigofera Tinctoria ◽  
Antidotal Activity

Background: Vatsanabha is a potent cardiac poison comes under the category of Mahavisha with its main active principles aconitine, picraconine and pseudaconine. In the literatures there are descriptions about toxicants and in some traditional Malayalam textbooks antidotes has been explained under the concept “Prathyoushadha”. Neeli Moola has been mentioned as a Prathyoushadha for Vatsanabha poisoning in a renowned textbook „Visha Vaidya Jyotsnika‟. Hence to evaluate the antidotal activity in Vatsanabha poisoning, Neeli Moola Kalka has been used and the haematological parameters were analyzed to screen the results. Methods: Wistar strain albino rats were used in this study which were divided into 3 groups, normal control, toxic control and the test drug group. The duration of the study was 28 days .The data generated was mentioned as Mean±SEM. Difference among the groups was assessed by employing one way ANOVA followed by Dunnet‟s mul tiple „t‟ test. Results: Reversible action has been observed after the administration of Neeli Moola Kalka in the hematological parameters which has shown toxicity changes due to administration of Vatsanabha. Conclusion: Neeli Moola Kalka is having mild to moderate antidote effect in Vatsanbha induced toxicity.

Sign in / Sign up

Export Citation Format

Share Document