scholarly journals The secret life of calcium in cell signaling

2019 ◽  
Vol 41 (4) ◽  
pp. 34-37
Author(s):  
Sandip Patel
Keyword(s):  
Cell Signaling ◽  
Calcium Ions ◽  
Alkaline Earth ◽  
Earth Metal ◽  
The Body ◽  
Alkaline Earth Metal ◽  
Critical Function ◽  
Hard Tissues

Calcium is an abundant alkaline earth metal. In the body, it is found as calcium ions (Ca2+), and most of it is deposited in hard tissues such as bones and teeth. But less well known is the role of Ca2+ as a messenger within cells. Here, I provide an overview of this hidden but critical function of Ca2+.

Promoting effect and role of alkaline earth metal added to ZrO2-TiO2-supported CeO2 for dichloromethane oxidation

2020 ◽  
Vol 396 ◽  
pp. 125193
Author(s):  
Ning Gao ◽  
Yukang Zhou ◽  
Mengjie Fan ◽  
Haitao Xu ◽  
Yingwen Chen ◽  
...  
Keyword(s):  
Alkaline Earth ◽  
Earth Metal ◽  
Alkaline Earth Metal ◽  
Promoting Effect

scholarly journals Structure-guided DNA–DNA attraction mediated by divalent cations

2020 ◽  
Author(s):  
Amit Srivastava ◽  
Raju Timsina ◽  
Seung Heo ◽  
Sajeewa W Dewage ◽  
Serdal Kirmizialtin ◽  
...  
Keyword(s):  
Electrostatic Interactions ◽  
Alkaline Earth ◽  
Divalent Cations ◽  
Random Sequence ◽  
Earth Metal ◽  
Alkaline Earth Metal ◽  
Sequence Dependent ◽  
Phosphate Backbone ◽  
Alkaline Earth Metal Ions

Abstract Probing the role of surface structure in electrostatic interactions, we report the first observation of sequence-dependent dsDNA condensation by divalent alkaline earth metal cations. Disparate behaviors were found between two repeating sequences with 100% AT content, a poly(A)-poly(T) duplex (AA-TT) and a poly(AT)-poly(TA) duplex (AT-TA). While AT-TA exhibits non-distinguishable behaviors from random-sequence genomic DNA, AA-TT condenses in all alkaline earth metal ions. We characterized these interactions experimentally and investigated the underlying principles using computer simulations. Both experiments and simulations demonstrate that AA-TT condensation is driven by non-specific ion–DNA interactions. Detailed analyses reveal sequence-enhanced major groove binding (SEGB) of point-charged alkali ions as the major difference between AA-TT and AT-TA, which originates from the continuous and close stacking of nucleobase partial charges. These SEGB cations elicit attraction via spatial juxtaposition with the phosphate backbone of neighboring helices, resulting in an azimuthal angular shift between apposing helices. Our study thus presents a distinct mechanism in which, sequence-directed surface motifs act with cations non-specifically to enact sequence-dependent behaviors. This physical insight allows a renewed understanding of the role of repeating sequences in genome organization and regulation and offers a facile approach for DNA technology to control the assembly process of nanostructures.

scholarly journals Prolonged QT Syndrome and Seizure Secondary to Alkaline Earth Metal Deficiency: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-5
Author(s):  
A. McKinney ◽  
B. C. Keegan
Keyword(s):  
Case Report ◽  
Alkaline Earth ◽  
Cell Function ◽  
Earth Metal ◽  
The Body ◽  
Alkaline Earth Metal ◽  
Qtc Interval ◽  
Electrolyte Disturbance ◽  
Metal Deficiency ◽  
Qt Syndrome

Introduction. Alkaline earth metal deficiency is recognized as a cause of both seizure and long QT syndrome. Their deficiency can have significant repercussions on the function of cells, tissues, and organs of the body. An understanding of the role of electrolytes allows an appreciation of the significance of depleted levels on cell function.Case Report. A 65-year-old lady was admitted with symptoms of chest discomfort, vomiting, increased stoma output, and dizziness. Two days following admission she suffered a tonic-clonic seizure. ECG review demonstrated a prolonged QTc interval, raising the possibility of an underlying Torsades de Pointes as the precipitant. This was attributed to electrolyte disturbance arising as a result of multiple aetiologies.Discussion. This paper highlights the multisystem effects of electrolyte disturbance, with emphasis upon its role in precipitating cardiac arrhythmia and neurological symptoms.

The Role of Alkali and Alkaline Earth Metal Ions in Cellulosic Smoldering

1994 ◽  
Vol 12 (4) ◽  
pp. 357-375 ◽  
Author(s):  
Arthur M. Ihrig ◽  
Shirley L. Smith
Keyword(s):  
Metal Ions ◽  
Alkaline Earth ◽  
Earth Metal ◽  
Alkaline Earth Metal ◽  
Tobacco Products ◽  
Alkaline Earth Metal Ions

The process of smoldering plays a key role in the combustion of tobacco products and textiles. Smoldering is strongly influenced by the concen tration and nature of ions present in the material.

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