scholarly journals Progesterone induces nano-scale molecular modifications on endometrial epithelial cell surfaces

2009 ◽  
Vol 101 (8) ◽  
pp. 481-493 ◽  
Author(s):  
Lewis W. Francis ◽  
Paul D. Lewis ◽  
Deyarina Gonzalez ◽  
Timothy A. Ryder ◽  
Gordon Webb ◽  
...  
Author(s):  
A. Toledo ◽  
G. Stoelk ◽  
M. Yussman ◽  
R.P. Apkarian

Today it is estimated that one of every three women in the U.S. will have problems achieving pregnancy. 20-30% of these women will have some form of oviductal problems as the etiology of their infertility. Chronically damaged oviducts present problems with loss of both ciliary and microvillar epithelial cell surfaces. Estradiol is known to influence cyclic patterns in secretory cell microvilli and tubal ciliogenesis, The purpose of this study was to assess whether estrogen therapy could stimulate ciliogenesis in chronically damaged human fallopian tubes.Tissues from large hydrosalpinges were obtained from six women undergoing tuboplastic repair while in the early proliferative phase of fheir menstrual cycle. In each case the damaged tissue was rinsed in heparinized Ringers-lactate and quartered.


Endocrinology ◽  
2008 ◽  
Vol 150 (1) ◽  
pp. 350-356 ◽  
Author(s):  
Yasushi Hirota ◽  
Yutaka Osuga ◽  
Akiko Hasegawa ◽  
Ako Kodama ◽  
Toshiki Tajima ◽  
...  

2018 ◽  
Vol 233 (10) ◽  
pp. 6965-6974 ◽  
Author(s):  
Lei Zhang ◽  
Xiaorui Liu ◽  
Xingna Ma ◽  
Yuexia Liu ◽  
Sicheng Che ◽  
...  

EBioMedicine ◽  
2015 ◽  
Vol 2 (10) ◽  
pp. 1528-1535 ◽  
Author(s):  
Carly Cuman ◽  
Michelle Van Sinderen ◽  
Michael P. Gantier ◽  
Kate Rainczuk ◽  
Kelli Sorby ◽  
...  

Genes ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 1052
Author(s):  
Jiuzeng Cui ◽  
Xiaorui Liu ◽  
Lichun Yang ◽  
Sicheng Che ◽  
Hongran Guo ◽  
...  

The endometrium undergoes a series of complex changes to form a receptive endometrium (RE) that allows the embryo to be implanted. The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a class of noncoding RNAs. Studies have found that miRNAs can regulate many critical physiological processes, including the establishment of RE during embryo implantation. miR-184 is highly expressed in the endometrial receptive period of dairy goats. This study aimed to explore the effect of miR-184 on endometrial epithelial cell (EEC) apoptosis and RE establishment. Stanniocalcin2 (STC2) is a direct target of miR-184, and miR-184 decreases the expression of STC2 in dairy goat EECs. miR-184 can activate EECs apoptosis through the RAS/RAF/MEK/ERK pathway. Additionally, miR-184 increases the expression levels of RE marker genes, such as forkhead box M1 (FOXM1) and vascular endothelial growth factor (VEGF). These findings indicate that miR-184 promotes the apoptosis of endometrial epithelial cells in dairy goats by downregulating STC2 via the RAS/RAF/MEK/ERK pathway, and that it may also regulate the establishment of RE in dairy goats.


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