Testinwas regulated by circRNA3175-miR182 and inhibited endometrial epithelial cell apoptosis in pre-receptive endometrium of dairy goats

2018 ◽  
Vol 233 (10) ◽  
pp. 6965-6974 ◽  
Author(s):  
Lei Zhang ◽  
Xiaorui Liu ◽  
Xingna Ma ◽  
Yuexia Liu ◽  
Sicheng Che ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Apoptosis ◽  
Dairy Goats ◽  
Endometrial Epithelial Cell ◽  
Epithelial Cell Apoptosis

scholarly journals MiR-184 Combined with STC2 Promotes Endometrial Epithelial Cell Apoptosis in Dairy Goats via RAS/RAF/MEK/ERK Pathway

Genes ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 1052
Author(s):  
Jiuzeng Cui ◽  
Xiaorui Liu ◽  
Lichun Yang ◽  
Sicheng Che ◽  
Hongran Guo ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Embryo Implantation ◽  
Animal Husbandry ◽  
Dairy Goat ◽  
Marker Genes ◽  
Erk Pathway ◽  
Dairy Goats ◽  
Endometrial Epithelial Cell ◽  
Forkhead Box M1 ◽  
Epithelial Cell Apoptosis

The endometrium undergoes a series of complex changes to form a receptive endometrium (RE) that allows the embryo to be implanted. The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a class of noncoding RNAs. Studies have found that miRNAs can regulate many critical physiological processes, including the establishment of RE during embryo implantation. miR-184 is highly expressed in the endometrial receptive period of dairy goats. This study aimed to explore the effect of miR-184 on endometrial epithelial cell (EEC) apoptosis and RE establishment. Stanniocalcin2 (STC2) is a direct target of miR-184, and miR-184 decreases the expression of STC2 in dairy goat EECs. miR-184 can activate EECs apoptosis through the RAS/RAF/MEK/ERK pathway. Additionally, miR-184 increases the expression levels of RE marker genes, such as forkhead box M1 (FOXM1) and vascular endothelial growth factor (VEGF). These findings indicate that miR-184 promotes the apoptosis of endometrial epithelial cells in dairy goats by downregulating STC2 via the RAS/RAF/MEK/ERK pathway, and that it may also regulate the establishment of RE in dairy goats.

miR‐34a/c induce caprine endometrial epithelial cell apoptosis by regulating circ‐8073/ CEP55 via the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways

2020 ◽  
Vol 235 (12) ◽  
pp. 10051-10067 ◽  
Author(s):  
Xiaorui Liu ◽  
Lei Zhang ◽  
Lichun Yang ◽  
Jiuzeng Cui ◽  
Sicheng Che ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Apoptosis ◽  
Endometrial Epithelial Cell ◽  
Epithelial Cell Apoptosis

scholarly journals TNF-αneutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis

2003 ◽  
Vol 100 (14) ◽  
pp. 8366-8371 ◽  
Author(s):  
Marco Marini ◽  
Giorgos Bamias ◽  
Jesús Rivera-Nieves ◽  
Christopher A. Moskaluk ◽  
Sharon B. Hoang ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Apoptosis ◽  
Intestinal Epithelial Cell ◽  
Intestinal Epithelial ◽  
Epithelial Cell Apoptosis
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