Development of a cell-based assay for screening of phosphodiesterase 10A (PDE10A) inhibitors using a stable recombinant HEK-293 cell line expressing high levels of PDE10A

2008 ◽  
Vol 49 (2) ◽  
pp. 129 ◽  
Author(s):  
Roop Singh Bora ◽  
Dikshi Gupta ◽  
Renu Malik ◽  
Sonia Chachra ◽  
Pratibha Sharma ◽  
...  
Keyword(s):  
Cell Line ◽  
Hek 293 ◽  
A Cell ◽  
Phosphodiesterase 10A ◽  
Hek 293 Cell Line

The time course of Akt and ERK activation on XIAP expression in HEK 293 cell line

2009 ◽  
Vol 37 (4) ◽  
pp. 2037-2042 ◽  
Author(s):  
Mousa Abkhezr ◽  
Ali Reza Keramati ◽  
Seyed Nasser Ostad ◽  
Jamshid Davoodi ◽  
Mohammad H. Ghahremani
Keyword(s):  
Cell Line ◽  
Time Course ◽  
Hek 293 ◽  
Erk Activation ◽  
Xiap Expression ◽  
Hek 293 Cell Line

scholarly journals Enhancing the Butyrylcholinesterase Activity in HEK-293 Cell Line by Dual-Promoter Vector Decorated on Lipofectamine

2020 ◽  
Vol Volume 14 ◽  
pp. 3589-3599
Author(s):  
Vida Mirzaie ◽  
Touba Eslaminejad ◽  
Homayoon Babaei ◽  
Seyed Noureddin Nematollahi-Mahani
Keyword(s):  
Cell Line ◽  
Hek 293 ◽  
Dual Promoter ◽  
Butyrylcholinesterase Activity ◽  
Hek 293 Cell Line

scholarly journals Design, synthesis and biological evaluation of 1,2,3-triazole based 2-aminobenzimidazoles as novel inhibitors of LasR dependent quorum sensing in Pseudomonas aeruginosa

RSC Advances ◽  
2019 ◽  
Vol 9 (50) ◽  
pp. 29273-29292 ◽  
Author(s):  
Singireddi Srinivasarao ◽  
Adinarayana Nandikolla ◽  
Shashidhar Nizalapur ◽  
Tsz Tin Yu ◽  
Sravani Pulya ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Quorum Sensing ◽  
Cell Line ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Hek 293 ◽  
Line P ◽  
Synthesis And Biological Evaluation ◽  
Hek 293 Cell Line

Out of 40 benzimdazoles, 12 exhibited potent QSI activity against P. aeruginosa6p, most active QSI is docked to LasR and is less toxic against HEK 293 cell line.

Hypoxia Differently Modulates Gene Expression of Inositol 1,4,5-Trisphosphate Receptors in Mouse Kidney and HEK 293 Cell Line

2008 ◽  
Vol 1148 (1) ◽  
pp. 421-427 ◽  
Author(s):  
Dana Jurkovicova ◽  
Barbora Sedlakova ◽  
Lubica Lacinova ◽  
Juraj Kopacek ◽  
Zdena Sulova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Line ◽  
Mouse Kidney ◽  
Hek 293 ◽  
Inositol 1,4,5 Trisphosphate ◽  
Hek 293 Cell Line

Changes in ultrastructure and endogenous ionic channels activity during culture of HEK 293 cell line

2007 ◽  
Vol 567 (1-2) ◽  
pp. 10-18 ◽  
Author(s):  
Martina Kurejová ◽  
Branislav Uhrík ◽  
Zdenka Sulová ◽  
Barbora Sedláková ◽  
Olga Križanová ◽  
...  
Keyword(s):  
Cell Line ◽  
Ionic Channels ◽  
Hek 293 ◽  
Hek 293 Cell Line

scholarly journals The study of cellular cytotoxicity of argireline - an anti-aging peptide.

2014 ◽  
Vol 61 (1) ◽  
Author(s):  
Marek Grosicki ◽  
Gniewomir Latacz ◽  
Annamaria Szopa ◽  
Anna Cukier ◽  
Katarzyna Kieć-Kononowicz
Keyword(s):  
Cell Line ◽  
Cellular Proliferation ◽  
Human Neuroblastoma ◽  
Hek 293 ◽  
Ic50 Value ◽  
Aging Product ◽  
Ic50 Values ◽  
Dose Dependent ◽  
Product Manufacturer ◽  
Hek 293 Cell Line

Argireline is well know, innovative anti-aging product used in the cosmetic market. This short chain peptide is used as active ingredient in dermal ointment and creams. Argireline prevents formation of skin lines and wrinkles in a very similar way to the botulinum toxin (Botox), inhibiting neurotransmitter release at the neuromuscular junction. Argireline does not require under skin muscle injections and it is believed to be relatively safe. However, despite the fact that some toxicity data has been provided by the product manufacturer, there is an evident lack of reliable information about cytotoxicity of argireline in the literature. The aim of the presented study was to estimate the antiproliferation effect of argireline solution in several concentrations. The influence of argireline on cellular proliferation was examined against: human embryonic kidney HEK-293 cell line, human neuroblastoma IMR-32 cell line, and human primary skin fibroblasts. Tests were performed using formazan-based cell proliferation assay: EZ4U, which allows to measure the efficiency of mitochondrial oxidative activity in living cells. The argireline inhibitory concentration, IC50 values were calculated and the results were compared to the IC50 value of the reference compound: doxorubicin. In conclusion, the considered method resulted in dose-dependent argireline anti-proliferation effects. However, the significant cytotoxicity of argireline solution was observed under 18 to 10 000 fold higher concentrations (depending on cells that were examined) in comparison to doxorubicin.

Long-term effects on HEK-293 cell line after co-culture with porcine endogenous retrovirus

2005 ◽  
Vol 37 (1) ◽  
pp. 496-499 ◽  
Author(s):  
P. Yu ◽  
L. Zhang ◽  
S.F. Li ◽  
Y.P. Li ◽  
J.Q. Cheng ◽  
...  
Keyword(s):  
Cell Line ◽  
Endogenous Retrovirus ◽  
Long Term Effects ◽  
Hek 293 ◽  
Porcine Endogenous Retrovirus ◽  
Hek 293 Cell Line
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