Structural studies on bio-active compounds. Part 25. Synthesis and properties of potential metabolites of the diaminopyrimidine antifolate 2,4-diamino-5-(3-azido-4-chlorophenyl)-6-ethylpyrimidine (MZPES)

Structural studies on bio-active compounds. Part 12. Tautomerism and conformation of aryl-substituted 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones in the solid phase and in solution

Journal of the Chemical Society Perkin Transactions 2 ◽

10.1039/p29890001275 ◽

1989 ◽

pp. 1275 ◽

Cited By ~ 15

Author(s):

Bernadette D. M. Cunningham ◽

Philip R. Lowe ◽

Michael D. Threadgill

Keyword(s):

Solid Phase ◽

Structural Studies ◽

Active Compounds ◽

Substituted 1

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Structural studies on bio-active compounds. 20. Molecular modeling and crystallographic studies on methylbenzoprim, a potent inhibitor of dihydrofolate reductase

Journal of Medicinal Chemistry ◽

10.1021/jm00090a023 ◽

1992 ◽

Vol 35 (12) ◽

pp. 2315-2320 ◽

Cited By ~ 7

Author(s):

Brian J. Denny ◽

Neil S. Ringan ◽

Carl H. Schwalbe ◽

Peter A. Lambert ◽

Michelle A. Meek ◽

...

Keyword(s):

Molecular Modeling ◽

Dihydrofolate Reductase ◽

Potent Inhibitor ◽

Structural Studies ◽

Active Compounds

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Structural studies on bio-active compounds. Part 11. Molecular modelling, crystallographic, and biochemical studies of the interactions of (±)-α-vinylserine with the enzyme serine hydroxymethyltransferase

Journal of the Chemical Society Perkin Transactions 2 ◽

10.1039/p29890000431 ◽

1989 ◽

pp. 431-436 ◽

Cited By ~ 5

Author(s):

Saul J. B. Tendler ◽

Carl H. Schwalbe ◽

Michael D. Threadgill ◽

Michael J. Tisdale ◽

LaVerne Schirch

Keyword(s):

Molecular Modelling ◽

Serine Hydroxymethyltransferase ◽

Structural Studies ◽

Active Compounds ◽

Biochemical Studies

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Structural studies on bio-active compounds. Part 5. Synthesis and properties of 2,4-diaminopyrimidine dihydrofolate reductase inhibitors bearing lipophilic azido groups

Journal of the Chemical Society Perkin Transactions 1 ◽

10.1039/p19870002217 ◽

1987 ◽

pp. 2217 ◽

Cited By ~ 21

Author(s):

Edward A. Bliss ◽

Roger J. Griffin ◽

Malcolm F. G. Stevens

Keyword(s):

Dihydrofolate Reductase ◽

Structural Studies ◽

Active Compounds ◽

Reductase Inhibitors ◽

Dihydrofolate Reductase Inhibitors

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ChemInform Abstract: STRUCTURAL STUDIES ON BIO-ACTIVE COMPOUNDS. PART 2. THE SOLID-STATE AND SOLUTION CONFORMATIONS OF N-METHYL-2-NITROETHENAMINE AND RELATED COMPOUNDS

Chemischer Informationsdienst ◽

10.1002/chin.198524070 ◽

1985 ◽

Vol 16 (24) ◽

Author(s):

E. N. GATE ◽

M. A. MEEK ◽

C. H. SCHWALBE ◽

M. F. G. STEVENS ◽

M. D. THREADGILL

Keyword(s):

Solid State ◽

Structural Studies ◽

Active Compounds ◽

Solution Conformations ◽

Related Compounds

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Structural studies on bio-active compounds. Part 2. The solid-state and solution conformations of N-methyl-2-nitroethenamine and related compounds

Journal of the Chemical Society Perkin Transactions 2 ◽

10.1039/p29850000251 ◽

1985 ◽

pp. 251 ◽

Cited By ~ 12

Author(s):

E. Nicholas Gate ◽

Michelle A. Meek ◽

Carl H. Schwalbe ◽

Malcolm F. G. Stevens ◽

Michael D. Threadgill

Keyword(s):

Solid State ◽

Structural Studies ◽

Active Compounds ◽

Solution Conformations ◽

Related Compounds

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Structural studies on bio-active compounds. Part 3. Re-examination of the hydrolysis of the antimalarial drug pyrimethamine and related derivatives and crystal structure of a hydrolysis product

Journal of the Chemical Society Perkin Transactions 1 ◽

10.1039/p19850002267 ◽

1985 ◽

pp. 2267 ◽

Cited By ~ 8

Author(s):

Roger J. Griffin ◽

Carl H. Schwalbe ◽

Malcolm F. G. Stevens ◽

Kait P. Wong

Keyword(s):

Crystal Structure ◽

Antimalarial Drug ◽

Hydrolysis Product ◽

Structural Studies ◽

Active Compounds ◽

Hydrolysis Of

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Structural studies on bio-active compounds. Part 6. Determination of the sites of protonation on three 2,4-diaminopyrimidines of pharmaceutical importance by proton-coupled 13C and 1H nuclear magnetic resonance spectroscopy

Journal of the Chemical Society Perkin Transactions 1 ◽

10.1039/p19870002229 ◽

1987 ◽

pp. 2229 ◽

Cited By ~ 7

Author(s):

Michael D. Threadgill ◽

Roger J. Griffin ◽

Malcolm F. G. Stevens ◽

Sang K. Wong

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Magnetic Resonance Spectroscopy ◽

Nuclear Magnetic Resonance Spectroscopy ◽

Resonance Spectroscopy ◽

Structural Studies ◽

Active Compounds ◽

1H Nuclear Magnetic Resonance ◽

Nuclear Magnetic

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Structural studies on bio-active compounds. Part XV. Structure-activity relationships for pyrimethamine and a series of diaminopyrimidine analogues versus bacterial dihydrofolate reductase

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ◽

10.1016/0167-4838(89)90228-8 ◽

1989 ◽

Vol 995 (1) ◽

pp. 21-27 ◽

Cited By ~ 13

Author(s):

Clare E. Sansom ◽

Carl H. Schwalbe ◽

Peter A. Lambert ◽

Roger J. Griffin ◽

Malcolm F.G. Stevens

Keyword(s):

Dihydrofolate Reductase ◽

Structural Studies ◽

Active Compounds ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: Structural Studies on Bio-active Compounds. Part 3. Re-examination of the Hydrolysis of the Antimalarial Drug Pyrimethamine and Related Derivatives and Crystal Structure of a Hydrolysis Product.

Chemischer Informationsdienst ◽

10.1002/chin.198608198 ◽

1986 ◽

Vol 17 (8) ◽

Author(s):

R. J. GRIFFIN ◽

C. H. SCHWALBE ◽

M. F. G. STEVENS ◽

K. P. WONG

Keyword(s):

Crystal Structure ◽

Antimalarial Drug ◽

Hydrolysis Product ◽

Structural Studies ◽

Active Compounds ◽

Hydrolysis Of

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