Long wavelength photosensitizers related to chlorins and bacteriochlorins for use in photodynamic therapy

1992 ◽  
pp. 1377 ◽  
Author(s):  
Ravindra K. Pandey ◽  
Fuu-Yau Shiau ◽  
Kishore Ramachandran ◽  
Thomas J. Dougherty ◽  
Kevin M. Smith
Keyword(s):  
Photodynamic Therapy ◽  
Long Wavelength

scholarly journals A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers

2019 ◽  
Vol 27 (12) ◽  
pp. 2666-2675 ◽  
Author(s):  
Johannes Karges ◽  
Franz Heinemann ◽  
Federica Maschietto ◽  
Malay Patra ◽  
Olivier Blacque ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Long Wavelength ◽  
Polypyridyl Complex

Synthesis and evolution of S-Porphin sodium as a potential antitumor agent for photodynamic therapy against breast cancer

2019 ◽  
Vol 6 (3) ◽  
pp. 362-372 ◽  
Author(s):  
Xiao Wang ◽  
Li Li ◽  
Kun Zhang ◽  
Zhen Han ◽  
Zhijian Ding ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Tumor Cell ◽  
Antitumor Agent ◽  
The Novel ◽  
Tumor Cell Death ◽  
Long Wavelength ◽  
Potential Antitumor

The novel sensitizer S-Porphin sodium can generate ROS by radiation with a long wavelength to cause tumor cell death.

scholarly journals Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy)3 ]2+ Core

2019 ◽  
Vol 2019 (32) ◽  
pp. 3704-3712 ◽  
Author(s):  
Johannes Karges ◽  
Olivier Blacque ◽  
Philippe Goldner ◽  
Hui Chao ◽  
Gilles Gasser
Keyword(s):  
Photodynamic Therapy ◽  
Long Wavelength

scholarly journals Studies on photodynamic mechanism of a novel chlorine derivative (TDPC) and its antitumor effect for photodynamic therapy in vitro and in vivo

2015 ◽  
Vol 08 (01) ◽  
pp. 1540001 ◽  
Author(s):  
Ying Ye ◽  
Lai-Xing Wang ◽  
Dan-Ping Zhang ◽  
Yi-Jia Yan ◽  
Zhi-Long Chen
Keyword(s):  
Photodynamic Therapy ◽  
Drug Candidate ◽  
Rt Pcr ◽  
Oxygen Generation ◽  
Long Wavelength ◽  
Wavelength Absorption ◽  
Chlorine Derivative ◽  
Necrosis Factor

Photodynamic therapy (PDT) represents a promising method for treatment of cancerous tumors. The chemical and physical properties of used photosensitizer (PS) play key roles in the treatment efficacy. In this study, a novel PS, 5,10,15,20-tetrakis((5-dipropylamino)pentyl)-chlorin (TDPC) which displayed a characteristic long wavelength absorption peak at 650 nm were synthesized. It also shows a singlet oxygen generation rate of 4.257 min-1. Generally, TDPC is localized in mitochondria and nucleus of cell. After light irradiation with 650 nm laser, it can kill many types of cell, in addition, TDPC–PDT can destroy ECA-109 tumor in nude mice and a necrotic scab was formed eventually. The expression levels of many genes which regulated cell growth and apoptosis were determined by RT-PCR following TDPC–PDT. The results showed that it either increased or decreased, among which, the expression level of TNFSF13, a member of tumor necrosis factor superfamily, increased significantly. In general, TDPC is an effective antitumor PS in vitro and in vivo and is worthy of further study as a new drug candidate. TNFSF13 will be an important molecular target for the discovery of new PSs.

scholarly journals Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

2020 ◽  
Vol 142 (14) ◽  
pp. 6578-6587 ◽  
Author(s):  
Johannes Karges ◽  
Franz Heinemann ◽  
Marta Jakubaszek ◽  
Federica Maschietto ◽  
Chloé Subecz ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Polypyridyl Complexes ◽  
Long Wavelength

scholarly journals Enhanced Photodynamic Anticancer Activities of Multifunctional Magnetic Nanoparticles (Fe3O4) Conjugated with Chlorin e6 and Folic Acid in Prostate and Breast Cancer Cells

Nanomaterials ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 722 ◽  
Author(s):  
Kyong-Hoon Choi ◽  
Ki Nam ◽  
Guangsup Cho ◽  
Jin-Seung Jung ◽  
Bong Park
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Biological Effects ◽  
Chlorin E6 ◽  
Deep Penetration ◽  
Promising Alternative ◽  
Long Wavelength

Photodynamic therapy (PDT) is a promising alternative to conventional cancer treatment methods. Nonetheless, improvement of in vivo light penetration and cancer cell-targeting efficiency remain major challenges in clinical photodynamic therapy. This study aimed to develop multifunctional magnetic nanoparticles conjugated with a photosensitizer (PS) and cancer-targeting molecules via a simple surface modification process for PDT. To selectively target cancer cells and PDT functionality, core magnetic (Fe3O4) nanoparticles were covalently bound with chlorin e6 (Ce6) as a PS and folic acid (FA). When irradiated with a 660-nm long-wavelength light source, the Fe3O4-Ce6-FA nanoparticles with good biocompatibility exerted marked anticancer effects via apoptosis, as confirmed by analyzing the translocation of the plasma membrane, nuclear fragmentation, activities of caspase-3/7 in prostate (PC-3) and breast (MCF-7) cancer cells. Ce6, used herein as a PS, is thus more useful for PDT because of its ability to produce a high singlet oxygen quantum yield, which is owed to deep penetration by virtue of its long-wavelength absorption band; however, further in vivo studies are required to verify its biological effects for clinical applications.

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