Synthetic approaches to long-wavelength photosensitizers for photodynamic therapy and their preliminary biological activity

1995 ◽  
Author(s):  
R. K. Pandey
Keyword(s):  
Biological Activity ◽  
Photodynamic Therapy ◽  
Long Wavelength ◽  
Synthetic Approaches

Synthetic approaches to long-wavelength photosensitizers for photodynamic therapy

1991 ◽  
Author(s):  
Fuu-Yau Shiau ◽  
Ravindra K. Pandey ◽  
Thomas J. Dougherty ◽  
Kevin M. Smith
Keyword(s):  
Photodynamic Therapy ◽  
Long Wavelength ◽  
Synthetic Approaches

Synthesis and Biological Potentials of Quinoline Analogues: A Review of Literature

2019 ◽  
Vol 16 (7) ◽  
pp. 653-688 ◽  
Author(s):  
Leena Kumari ◽  
Salahuddin ◽  
Avijit Mazumder ◽  
Daman Pandey ◽  
Mohammad Shahar Yar ◽  
...  
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds ◽  
Building Blocks ◽  
Vital Role ◽  
Review Of Literature ◽  
Drug Discovery Process ◽  
Active Compounds ◽  
Lead Compounds ◽  
Synthetic Approaches ◽  
Derivatives Of

Heterocyclic compounds are well known for their different biological activity. The heterocyclic analogs are the building blocks for synthesis of the pharmaceutical active compounds in the organic chemistry. These derivatives show various type of biological activity like anticancer, antiinflammatory, anti-microbial, anti-convulsant, anti-malarial, anti-hypertensive, etc. From the last decade research showed that the quinoline analogs plays a vital role in the development of newer medicinal active compounds for treating various type of disease. Quinoline reported for their antiviral, anticancer, anti-microbial and anti-inflammatory activity. This review will summarize the various synthetic approaches for synthesis of quinoline derivatives and to check their biological activity. Derivatives of quinoline moiety plays very important role in the development of various types of newer drugs and it can be used as lead compounds for future investigation in the field of drug discovery process.

scholarly journals Design and biological activity of novel stealth polymeric lipid nanoparticles for enhanced delivery of hydrophobic photodynamic therapy drugs

2018 ◽  
Vol 14 (7) ◽  
pp. 2295-2305 ◽  
Author(s):  
Mathias Viard ◽  
Henry Reichard ◽  
Bruce A. Shapiro ◽  
Farukh A Durrani ◽  
Aimee J Marko ◽  
...  
Keyword(s):  
Biological Activity ◽  
Photodynamic Therapy ◽  
Lipid Nanoparticles

Synthesis and characterization of a new natural product analog, 132-173-bacteriochlorophyllone a

2014 ◽  
Vol 18 (03) ◽  
pp. 188-199 ◽  
Author(s):  
Áron Roxin ◽  
Thomas D. MacDonald ◽  
Gang Zheng
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Photodynamic Therapy ◽  
Natural Product ◽  
Synthesis And Characterization ◽  
Facile Synthesis ◽  
H Nmr ◽  
F Ring ◽  
C Nmr

Here we show the facile synthesis of 132-173-bacteriochlorophyllone a (12), with a distinct seven-membered exocyclic F-ring formed by 132-173-cyclization of bacteriopheophorbide a(16). This is the latest reported bacteriochlorin with such an exocyclic F-ring since 1975 (132-173 cyclobacteriopheophorbide a-enol, 11), and is an analog of previously described natural exocyclic F-ring-containing porphyrins (1–4) and chlorins (5–10). The structure of 12 was confirmed using a combination of 1D 1 H NMR, 2D COSY 1 H NMR, Jmod 13 C NMR and HRMS analysis. The biological activity of 12 was explored, and we found that this compound does not possess strong antioxidant activity like its natural product counterparts, but is a capable photosensitizer for photodynamic therapy.

scholarly journals A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers

2019 ◽  
Vol 27 (12) ◽  
pp. 2666-2675 ◽  
Author(s):  
Johannes Karges ◽  
Franz Heinemann ◽  
Federica Maschietto ◽  
Malay Patra ◽  
Olivier Blacque ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Long Wavelength ◽  
Polypyridyl Complex

The Influence of Hydrogen Donors on Breakage of Parental DNA Strands and on Biological Activity of Transforming BrU-DNA of B. subtilis after 302/313 nm Radiation

1974 ◽  
Vol 29 (1-2) ◽  
pp. 66-71
Author(s):  
Wolfgang Köhnlein
Keyword(s):  
Molecular Weight ◽  
Biological Activity ◽  
Uv Irradiation ◽  
Strand Breaks ◽  
Protective Agents ◽  
Long Wavelength ◽  
Hydrogen Donors ◽  
Dna Strands

Abstract Long wavelength UV irradiation (302/313 nm) of hybrid and bifilarly labeled BrU-DNA of B. subtilis results in a degradation of the molecular weight of BrU and of parental thymine con­ taining DNA strands. Hydrogen donors present during UV irradiation are able to prevent these “primary” and “secondary” strand breaks. The protection factors are especially large for secondary breaks in parental normal DNA. Through the action of protective agents the biological activity could not be restored. The generation of these primary and secondary strand breaks due to BrU incorporation and the action of hydrogen donors discussed.

Synthetic approaches to 1,2,5-benzothiadiazepine 1,1-dioxides – sulfonamide analogues of the 1,4-benzodiazepines

2005 ◽  
Vol 2005 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Karl Hemming ◽  
Christina Loukou
Keyword(s):  
Biological Activity ◽  
Reverse Transcriptase ◽  
Biological Interest ◽  
Synthetic Approaches

Synthetic approaches to the 1,2,5-benzothiadiazepine 1,1-dioxides, sulfonamide analogues of the 1,4-benzodiazepines, are reviewed. The review incorporates the synthesis of bicyclic, tricyclic and tetracyclic systems, and includes approaches to sulfonamide analogues of the antitumour pyrrolobenzodiazepines, sulfonamide analogues of the tricyclic non-nucleosidic reverse transcriptase inhibiting benzodiazepines (such as nevirapine), and other systems of biological interest. Details of the reactions and biological activity of the 1,2,5-benzothiadiazepines are also given.

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