Direct synthesis of N-protected chiral amino acids from imidodicarbonates employing either Mitsunobu or triflate alkylation. Feasibility study using lactate with particular reference to 15N-labelling

Author(s):  
Fredrik Degerbeck ◽  
Bengt Fransson ◽  
Leif Grehn ◽  
Ulf Ragnarsson
Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5270
Author(s):  
Zhenbo Yuan ◽  
Xuanzhong Liu ◽  
Changmei Liu ◽  
Yan Zhang ◽  
Yijian Rao

Non-proteinogenic amino acids have attracted tremendous interest for their essential applications in the realm of biology and chemistry. Recently, rising C–H functionalization has been considered an alternative powerful method for the direct synthesis of non-proteinogenic amino acids. Meanwhile, photochemistry has become popular for its predominant advantages of mild conditions and conservation of energy. Therefore, C–H functionalization and photochemistry have been merged to synthesize diverse non-proteinogenic amino acids in a mild and environmentally friendly way. In this review, the recent developments in the photo-mediated C–H functionalization of proteinogenic amino acids derivatives for the rapid synthesis of versatile non-proteinogenic amino acids are presented. Moreover, postulated mechanisms are also described wherever needed.


2008 ◽  
Vol 38 (23) ◽  
pp. 4107-4115 ◽  
Author(s):  
Qian Yang ◽  
Xiao-jian Wang ◽  
Zhi-yu Li ◽  
Li Sun ◽  
Qi-dong You

2004 ◽  
Vol 53 (12) ◽  
pp. 1507-1514
Author(s):  
Yoshinori TAKANO ◽  
Katsumi MARUMO ◽  
Kensei KOBAYASHI ◽  
Jun-ichi TAKAHASHI

ChemInform ◽  
2008 ◽  
Vol 39 (30) ◽  
Author(s):  
Taichi Kano ◽  
Akihiro Yamamoto ◽  
Haruka Mii ◽  
Jun Takai ◽  
Seiji Shirakawa ◽  
...  

ChemInform ◽  
2010 ◽  
Vol 41 (42) ◽  
Author(s):  
Z. G. Zhang ◽  
S. F. Zhang ◽  
H. Wang ◽  
J. W. Liu ◽  
M. Zhu

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