Thermal fragmentation of a 1,5,2-oxathiazole 5-oxide system via two parallel pathways: interception of a vinyl nitrene and of a sulphene

1983 ◽  
pp. 2097 ◽  
Author(s):  
Bianca F. Bonini ◽  
Gaetano Maccagnani ◽  
Germana Mazzanti ◽  
Paola Pedrini ◽  
Ben H. M. Lammerink ◽  
...  
Keyword(s):  
Oxide System ◽  
Thermal Fragmentation ◽  
Parallel Pathways ◽  
Vinyl Nitrene

Effect of lead acetate on the nitric oxide system in rat tissue

2008 ◽  
Vol 21 (1) ◽  
pp. 175-178
Author(s):  
Isaac Trakhtenberg ◽  
Olena Apykhtina ◽  
Anatoly Kotsuruba ◽  
Julia Korkach ◽  
Irina Andrusishina
Keyword(s):  
Nitric Oxide ◽  
Lead Acetate ◽  
Oxide System ◽  
Rat Tissue ◽  
Nitric Oxide System

Роль оксида азота в реализации антиоксидантного эффекта неопиатного аналога лей-энкефалина в сердце новорожденных белых крыс

2019 ◽  
pp. 61-64
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Postnatal Period ◽  
Oxide System ◽  
No Synthase ◽  
Albino Rats ◽  
Oxygen Species ◽  
Control Parameters ◽  
Synthase Inhibitor

The eff ect of the non-opiate analog of leu-enkephalin (peptide NALE: Phe – D – Ala – Gly – Phe – Leu – Arg) on the reactive oxygen species generation in the heart of albino rats in the early postnatal period was studied. Peptide NALE was administered intraperitoneally in the dose of 100 μ/kg daily from 2 to 6 days of life. Reactive oxygen species generation was assessed by chemiluminescence in the heart homogenates of 7-day-old animals. Decreasing of reactive oxygen species generation nearly by 30 % and an increasing in antioxidant system activity by the 20-27 %, compared with the control parameters, were found. The antioxidant eff ect of peptide NALE is associated with the presence of the amino acid Arg in the structure of the peptide. An analogue of NALE peptide, devoid of Arg (peptide Phe – D – Ala – Gly – Phe – Leu – Gly), had a signifi cant lower antioxidant eff ect. The NO-synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) in the dose 50 mg/kg, administered with NALE peptide, reduced the severity of the NALE antioxidant eff ect. The results of the study suggest that the pronounced antioxidant eff ect of NALE peptide in the heart of albino rats, at least in part, is due to the interaction with the nitric oxide system.

scholarly journals Low Force Unfolding of a Single-Domain Protein by Parallel Pathways

2021 ◽  
Vol 125 (7) ◽  
pp. 1799-1805
Author(s):  
Pavel I. Zhuravlev ◽  
Michael Hinczewski ◽  
D. Thirumalai
Keyword(s):  
Single Domain ◽  
Single Domain Protein ◽  
Parallel Pathways ◽  
Domain Protein

Evidence of an Intermediate and Parallel Pathways in Protein Unfolding from Single-Molecule Fluorescence

2008 ◽  
Vol 130 (25) ◽  
pp. 7898-7907 ◽  
Author(s):  
Angel Orte ◽  
Timothy D. Craggs ◽  
Samuel S. White ◽  
Sophie E. Jackson ◽  
David Klenerman
Keyword(s):  
Single Molecule ◽  
Protein Unfolding ◽  
Single Molecule Fluorescence ◽  
Parallel Pathways
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