scholarly journals Low Force Unfolding of a Single-Domain Protein by Parallel Pathways

2021 ◽  
Vol 125 (7) ◽  
pp. 1799-1805
Author(s):  
Pavel I. Zhuravlev ◽  
Michael Hinczewski ◽  
D. Thirumalai
Keyword(s):  
Single Domain ◽  
Single Domain Protein ◽  
Parallel Pathways ◽  
Domain Protein

scholarly journals The Speed of Allosteric Signaling Within a Single-Domain Protein

2021 ◽  
pp. 4262-4267
Author(s):  
Olga Bozovic ◽  
Jeannette Ruf ◽  
Claudio Zanobini ◽  
Brankica Jankovic ◽  
David Buhrke ◽  
...  
Keyword(s):  
Single Domain ◽  
Single Domain Protein ◽  
Domain Protein

scholarly journals Folding of a single domain protein entering the endoplasmic reticulum precedes disulfide formation

2017 ◽  
Vol 292 (17) ◽  
pp. 6978-6986 ◽  
Author(s):  
Philip J. Robinson ◽  
Marie Anne Pringle ◽  
Cheryl A. Woolhead ◽  
Neil J. Bulleid
Keyword(s):  
Endoplasmic Reticulum ◽  
Single Domain ◽  
Single Domain Protein ◽  
Disulfide Formation ◽  
Domain Protein

Complementation of peptide fragments of the single domain protein chymotrypsin inhibitor 2

1997 ◽  
Vol 273 (1) ◽  
pp. 317-329 ◽  
Author(s):  
Andreas G. Ladurner ◽  
Laura S. Itzhaki ◽  
Gonzalo de Prat Gay ◽  
Alan R. Fersht
Keyword(s):  
Single Domain ◽  
Peptide Fragments ◽  
Chymotrypsin Inhibitor ◽  
Single Domain Protein ◽  
Chymotrypsin Inhibitor 2 ◽  
Domain Protein

scholarly journals Evolutionary history of Ku proteins: evidence of horizontal gene transfer from archaea to eukarya

2020 ◽  
Author(s):  
Ashmita Mainali ◽  
Sadikshya Rijal ◽  
Hitesh Kumar Bhattarai
Keyword(s):  
Dna Repair ◽  
Gene Transfer ◽  
Horizontal Gene Transfer ◽  
Single Domain ◽  
End Joining ◽  
Entire Genome ◽  
Single Domain Protein ◽  
Eukaryotic Species ◽  
Domain Protein ◽  
Ku Protein

Abstract Background The DNA end joining protein, Ku, is essential in Non-Homologous End Joining in prokaryotes and eukaryotes. It was first discovered in eukaryotes and later by PSI blast, was discovered in prokaryotes. While Ku in eukaryotes is often a multi domain protein functioning in DNA repair of physiological and pathological DNA double stranded breaks, Ku in prokaryotes is a single domain protein functioning in pathological DNA repair in spores or late stationary phase. In this paper we have attempted to systematically search for Ku protein in different phyla of bacteria and archaea as well as in different kingdoms of eukarya. Result From our search of 116 sequenced bacterial genomes, only 25 genomes yielded at least one Ku sequence. From a comprehensive search of all NCBI archaeal genomes, we received a positive hit in 7 specific archaea that possessed Ku. In eukarya, we found Ku protein in 27 out of 59 species. Since the entire genome of all eukaryotic species is not fully sequenced this number could go up. We then drew a phylogenetic maximum likelihood tree to determine the ancestral relationship between Ku70 and Ku80 in eukaryotes and Ku in prokaryotes. Out tree revealed a common node for some archaeal Ku, Ku70 and Ku80. Conclusion This led us to hypothesize that Ku from archaea transferred through horizontal gene transfer onto neozoa and then duplicated to form Ku70 and Ku80. Additionally, we analyzed the domains of the different eukaryotic species to demonstrate that fusion, fission, terminal addition, terminal deletion, single domain loss, single domain emergence events during evolution.

scholarly journals On the origin and highly likely completeness of single-domain protein structures

2006 ◽  
Vol 103 (8) ◽  
pp. 2605-2610 ◽  
Author(s):  
Y. Zhang ◽  
I. A. Hubner ◽  
A. K. Arakaki ◽  
E. Shakhnovich ◽  
J. Skolnick
Keyword(s):  
Protein Structures ◽  
Single Domain ◽  
Single Domain Protein ◽  
Domain Protein

scholarly journals Insight into the Unfolding Properties of Chd64, a Small, Single Domain Protein with a Globular Core and Disordered Tails

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137074 ◽  
Author(s):  
Aneta Tarczewska ◽  
Małgorzata Kozłowska ◽  
Piotr Dobryszycki ◽  
Magdalena Kaus-Drobek ◽  
Michał Dadlez ◽  
...  
Keyword(s):  
Single Domain ◽  
Single Domain Protein ◽  
Domain Protein ◽  
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