6-Farnesyl-5,7-dihydroxy-4-methylphthalide oxidation mechanism in mycophenolic acid biosynthesis

1982 ◽  
pp. 365 ◽  
Author(s):  
Lino Colombo ◽  
Cesare Gennari ◽  
Donatella Potenza ◽  
Carlo Scolastico ◽  
Fabrizio Aragozzini ◽  
...  
Keyword(s):  
Mycophenolic Acid ◽  
Oxidation Mechanism ◽  
Acid Biosynthesis

Spore germination, colony development, and secondary metabolism in Penicillium brevicompactum: a radiogas chromatographic and morphological study

1978 ◽  
Vol 24 (12) ◽  
pp. 1490-1501 ◽  
Author(s):  
D. L. Doerfler ◽  
C. P. Nulton ◽  
C. D. Bartman ◽  
F. J. Gottlieb ◽  
I. M. Campbell
Keyword(s):  
Benzoic Acid ◽  
Mycophenolic Acid ◽  
Morphological Study ◽  
Colony Development ◽  
Acetate Metabolism ◽  
Shake Culture ◽  
Acid Biosynthesis ◽  
Batch Mode ◽  
Penicillium Brevicompactum ◽  
Dormant Spore

A study of the first 76 h of development of spores of Penicillium brevicompactum in batch-mode shake culture indicates that mycophenolic acid biosynthesis begins when the hyphae of germinating spores aggregate to form pellets. Supplies of mycophenolic acid so produced augment a pre-existing pool of the material that is associated with the dormant spore. Although acetate metabolism is active at all stages of development, incorporation of [1-14C]acetate into 2,4-dihydroxy-6-(1′,2′-dioxopropyl)benzoic acid, another secondary metabolite of the fungus, could not be demonstrated. The significance of these data are considered in terms of the function of mycophenolic acid and the substituted benzoic acid in the producing organism.

scholarly journals Immunosuppressant mycophenolic acid biosynthesis employs a new globin-like enzyme for prenyl side chain cleavage

2019 ◽  
Vol 9 (6) ◽  
pp. 1253-1258 ◽  
Author(s):  
Xiwei Chen ◽  
Lu Wang ◽  
Jinmei Zhang ◽  
Tao Jiang ◽  
Changhua Hu ◽  
...  
Keyword(s):  
Mycophenolic Acid ◽  
Side Chain ◽  
Acid Biosynthesis ◽  
Side Chain Cleavage ◽  
Chain Cleavage

Inhibition of early steps of de novo fatty-acid biosynthesis by different xenobiotica

1991 ◽  
Vol 81 (2) ◽  
pp. 251-255
Author(s):  
Manfred Focke ◽  
Andrea Feld ◽  
Hartmut K. Lichtenthaler
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Biosynthesis ◽  
De Novo ◽  
Acid Biosynthesis
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