Elimination reactions of cis- and trans-8a-hydroxy-2-thiadecalin 2,2-dioxide with thionyl chloride. Evidence for intermediacy of ion pairs

1977 ◽  
pp. 1561 ◽  
Author(s):  
Silvio Fabrissin ◽  
Silvana Fatutta ◽  
Amerigo Risaliti
Keyword(s):  
Thionyl Chloride ◽  
Ion Pairs ◽  
Elimination Reactions ◽  
Cis And Trans

Octahedral cobalt(III) complexes in dipolar aprotic solvents. II. Association between cis- and trans-dichlorobisethylenediamine cobalt(III) cations,[Co en2 Cl2]+, and chloride and bromide ions in the solvents NN-dimethylformamide, dimethyl sulphoxide, and LVN-dimethylacetamide

1966 ◽  
Vol 19 (1) ◽  
pp. 43 ◽  
Author(s):  
WA Millen ◽  
DW Watts
Keyword(s):  
Spectrophotometric Method ◽  
Ion Pairs ◽  
Ion Association ◽  
Ion Pair ◽  
Association Constants ◽  
Dimethyl Sulphoxide ◽  
Aprotic Solvents ◽  
Ion Association Constants ◽  
Cis And Trans ◽  
Dipolar Aprotic Solvents

Ion association constants at 30� have been determined for the cis-[Co en, Cl2]+Cl- ion pair in NN-dimethylformamide (DMF), NN-dimethylacetamide (DMA), and at 20.0�, 25.0�, and 30.0� in dimethyl sulphoxide (DMSO), by a spectrophotometric method. Association constants for the cis-[Co en2 Cl2]+Br- and the trans- [Co en2 Cl2]+Cl- ion pairs have also been determined in DMF at 30�.

Study of the reaction of cis- and trans-4-acylamino-3-hydroxythiophans with thionyl chloride

1975 ◽  
Vol 11 (2) ◽  
pp. 155-158
Author(s):  
S. D. Mikhno ◽  
T. M. Filippova ◽  
N. S. Kulachkina ◽  
I. G. Razumova ◽  
V. A. Zamureenko ◽  
...  
Keyword(s):  
Thionyl Chloride ◽  
Cis And Trans

Reaction of cis- and trans-4-alkoxycarbonylamino-3-hydroxythiophans with thionyl chloride

1975 ◽  
Vol 11 (3) ◽  
pp. 290-293
Author(s):  
S. D. Mikhno ◽  
T. M. Filippova ◽  
N. S. Kulachkina ◽  
I. G. Razumova ◽  
V. M. Berezovskii
Keyword(s):  
Thionyl Chloride ◽  
Cis And Trans

Preparation of antidotes for anticholinesterase poisoning. IV. Synthesis and protective effectiveness of 2′-(cis- and trans-2″-hydroxycyclohexyl)aminoethyl 1-phenylcyclopentanecarboxylate hydrochlorides

1970 ◽  
Vol 48 (9) ◽  
pp. 1377-1382 ◽  
Author(s):  
R. A. B. Bannard ◽  
J. H. Parkkari
Keyword(s):  
Thionyl Chloride ◽  
Similar Reaction ◽  
Cis And Trans ◽  
Hydrolysis Of ◽  
Protective Effectiveness

The syntheses of cis- and trans-2-aminocyclohexanols and of cis- and trans-2-ethylaminocyclohexanols are described. The cis isomers were prepared by treatment of the corresponding trans-2-acetamidocyclohexanols with thionyl chloride followed by hydrolysis of the resulting intermediate oxazolines. The 2-aminocyclohexanols were converted to 2′-(cis- and trans-2″-hydroxycyclohexyl)aminoethyl 1-phenyl-cyclopentanecarboxylate hydrochlorides (1 and 2, R = H) by treatment with 2′-bromoethyl 1-phenyl-cyclopentanecarboxylate, but attempts to convert the 2-ethylaminocyclohexanols to 1 and 2 (R = C2H5) by a similar reaction were unsuccessful. The anticholinesterase activities of several of the compounds are discussed, as are the potencies of 1 and 2 (R = H) in protecting mice and rats from sarin poisoning.

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