Biosynthetic studies on marine natural products

1989 ◽  
Vol 6 (2) ◽  
pp. 143 ◽  
Author(s):  
M. J. Garson
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Biosynthetic Studies

Marine Natural Products with High Anticancer Activities

2020 ◽  
Vol 27 (8) ◽  
pp. 1243-1307 ◽  
Author(s):  
Dario Matulja ◽  
Karlo Wittine ◽  
Nela Malatesti ◽  
Sylvain Laclef ◽  
Maris Turks ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Cancer Biology ◽  
Molecular Mechanisms ◽  
Recent Literature ◽  
Biological Activities ◽  
Anticancer Activities ◽  
Total Syntheses ◽  
Biosynthetic Studies ◽  
Shed Light

This review covers recent literature from 2012-2019 concerning 170 marine natural products and their semisynthetic analogues with strong anticancer biological activities. Reports that shed light on cellular and molecular mechanisms and biological functions of these compounds, thus advancing the understanding in cancer biology are also included. Biosynthetic studies and total syntheses, which have provided access to derivatives and have contributed to the proper structure or stereochemistry elucidation or revision are mentioned. The natural compounds isolated from marine organisms are divided into nine groups, namely: alkaloids, sterols and steroids, glycosides, terpenes and terpenoids, macrolides, polypeptides, quinones, phenols and polyphenols, and miscellaneous products. An emphasis is placed on several drugs originating from marine natural products that have already been marketed or are currently in clinical trials.

scholarly journals Recent highlights of biosynthetic studies on marine natural products

2021 ◽  
Vol 19 (1) ◽  
pp. 123-140
Author(s):  
Jamshid Amiri Moghaddam ◽  
Theresa Jautzus ◽  
Mohammad Alanjary ◽  
Christine Beemelmanns
Keyword(s):  
Natural Products ◽  
Marine Bacteria ◽  
Marine Natural Products ◽  
Bioactive Natural Products ◽  
Biosynthetic Studies

Marine bacteria are excellent yet often underexplored sources of structurally unique bioactive natural products.

The discoipyrroles: A multifaceted approach to understand a novel family of marine natural products

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
DA Colosimo ◽  
F Cai ◽  
Y Hu ◽  
MB Potts ◽  
MA White ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Multifaceted Approach

Synthesis of Marine Natural Products 1

1992 ◽  
Author(s):  
K. F. Albizati ◽  
V. A. Martin ◽  
M. R. Agharahimi ◽  
D. A. Stolze
Keyword(s):  
Natural Products ◽  
Marine Natural Products

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

Neuroprotective Activities of Marine Natural Products from Marine Sponges

2016 ◽  
Vol 23 (4) ◽  
pp. 360-382 ◽  
Author(s):  
Mousa Alghazwi ◽  
Yen Qi Kan ◽  
Wei Zhang ◽  
Wei Ping Gai ◽  
Xiao-Xin Yan
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Marine Sponges
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