scholarly journals Recent highlights of biosynthetic studies on marine natural products

2021 ◽  
Vol 19 (1) ◽  
pp. 123-140
Author(s):  
Jamshid Amiri Moghaddam ◽  
Theresa Jautzus ◽  
Mohammad Alanjary ◽  
Christine Beemelmanns
Keyword(s):  
Natural Products ◽  
Marine Bacteria ◽  
Marine Natural Products ◽  
Bioactive Natural Products ◽  
Biosynthetic Studies

Marine bacteria are excellent yet often underexplored sources of structurally unique bioactive natural products.

Pyrone-derived Marine Natural Products: A Review on Isolation, Bio-activities and Synthesis

2020 ◽  
Vol 24 (4) ◽  
pp. 354-401 ◽  
Author(s):  
Keisham S. Singh
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Marine Fungi ◽  
Kojic Acid ◽  
Biological Activities ◽  
Biological Significance ◽  
Pyrone Ring ◽  
Enol Ethers ◽  
Bioactive Natural Products ◽  
Marine Metabolites

Marine natural products (MNPs) containing pyrone rings have been isolated from numerous marine organisms, and also produced by marine fungi and bacteria, particularly, actinomycetes. They constitute a versatile structure unit of bioactive natural products that exhibit various biological activities such as antibiotic, antifungal, cytotoxic, neurotoxic, phytotoxic and anti-tyrosinase. The two structure isomers of pyrone ring are γ- pyrone and α-pyrone. In terms of chemical motif, γ-pyrone is the vinologous form of α- pyrone which possesses a lactone ring. Actinomycete bacteria are responsible for the production of several α-pyrone compounds such as elijopyrones A-D, salinipyrones and violapyrones etc. to name a few. A class of pyrone metabolites, polypropionates which have fascinating carbon skeleton, is primarily produced by marine molluscs. Interestingly, some of the pyrone polytketides which are found in cone snails are actually synthesized by actinomycete bacteria. Several pyrone derivatives have been obtained from marine fungi such as Aspergillums flavus, Altenaria sp., etc. The γ-pyrone derivative namely, kojic acid obtained from Aspergillus fungus has high commercial demand and finds various applications. Kojic acid and its derivative displayed inhibition of tyrosinase activity and, it is also extensively used as a ligand in coordination chemistry. Owing to their commercial and biological significance, the synthesis of pyrone containing compounds has been given attention over the past years. Few reviews on the total synthesis of pyrone containing natural products namely, polypropionate metabolites have been reported. However, these reviews skipped other marine pyrone metabolites and also omitted discussion on isolation and detailed biological activities. This review presents a brief account of the isolation of marine metabolites containing a pyrone ring and their reported bio-activities. Further, the review covers the synthesis of marine pyrone metabolites such as cyercene-A, placidenes, onchitriol-I, onchitriol-II, crispatene, photodeoxytrichidione, (-) membrenone-C, lihualide-B, macrocyclic enol ethers and auripyrones-A & B.

Marine natural products

2020 ◽  
Vol 37 (2) ◽  
pp. 175-223 ◽  
Author(s):  
Anthony R. Carroll ◽  
Brent R. Copp ◽  
Rohan A. Davis ◽  
Robert A. Keyzers ◽  
Michèle R. Prinsep
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Marine Bacteria ◽  
Marine Natural Products ◽  
Comprehensive Review

A comprehensive review of 1554 new MNPs, including numerous novel and bioactive compounds from marine bacteria.

scholarly journals Optimization of Marine Bacteria Microencapsulation for the Discovery of Novel Marine Natural Products

2020 ◽  
Author(s):  
Emily Pope ◽  
Tarteela Alkayyali ◽  
Sydney Wheatley ◽  
Christopher Cartmell ◽  
Jultwahnique McDonald ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Bacteria ◽  
Marine Natural Products

Marine Natural Products with High Anticancer Activities

2020 ◽  
Vol 27 (8) ◽  
pp. 1243-1307 ◽  
Author(s):  
Dario Matulja ◽  
Karlo Wittine ◽  
Nela Malatesti ◽  
Sylvain Laclef ◽  
Maris Turks ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Cancer Biology ◽  
Molecular Mechanisms ◽  
Recent Literature ◽  
Biological Activities ◽  
Anticancer Activities ◽  
Total Syntheses ◽  
Biosynthetic Studies ◽  
Shed Light

This review covers recent literature from 2012-2019 concerning 170 marine natural products and their semisynthetic analogues with strong anticancer biological activities. Reports that shed light on cellular and molecular mechanisms and biological functions of these compounds, thus advancing the understanding in cancer biology are also included. Biosynthetic studies and total syntheses, which have provided access to derivatives and have contributed to the proper structure or stereochemistry elucidation or revision are mentioned. The natural compounds isolated from marine organisms are divided into nine groups, namely: alkaloids, sterols and steroids, glycosides, terpenes and terpenoids, macrolides, polypeptides, quinones, phenols and polyphenols, and miscellaneous products. An emphasis is placed on several drugs originating from marine natural products that have already been marketed or are currently in clinical trials.

Biotransformations of Bioactive Natural Products with Complicated Structures

Planta Medica ◽  
2012 ◽  
Vol 78 (05) ◽  
Author(s):  
JG Dai ◽  
RD Chen ◽  
D Xie ◽  
JH Li ◽  
K Wang ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Natural Products
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