221. Deoxy-sugars. Part XVII. An investigation of the glycal method for the preparation of derivatives of 2-deoxy-D-galactose

1951 ◽  
pp. 992 ◽  
Author(s):  
W. G. Overend ◽  
F. Shafizadeh ◽  
M. Stacey
Keyword(s):  
Derivatives Of ◽  
Deoxy Sugars

Anti-influenza A virus activity of uridine derivatives of 2-deoxy sugars

2013 ◽  
Vol 100 (1) ◽  
pp. 90-97 ◽  
Author(s):  
Ewelina Krol ◽  
Ilona Wandzik ◽  
Beata Gromadzka ◽  
Dawid Nidzworski ◽  
Malgorzata Rychlowska ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Virus Activity ◽  
Derivatives Of ◽  
Deoxy Sugars

In vitro antiviral activity of some uridine derivatives of 2-deoxy sugars against classical swine fever virus

2010 ◽  
Vol 86 (2) ◽  
pp. 154-162 ◽  
Author(s):  
Ewelina Krol ◽  
Ilona Wandzik ◽  
Wieslaw Szeja ◽  
Grzegorz Grynkiewicz ◽  
Boguslaw Szewczyk
Keyword(s):  
Antiviral Activity ◽  
Classical Swine Fever Virus ◽  
Classical Swine Fever ◽  
Fever Virus ◽  
Derivatives Of ◽  
Deoxy Sugars

scholarly journals Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1129 ◽  
Author(s):  
Ewelina Krol ◽  
Ilona Wandzik ◽  
Gabriela Brzuska ◽  
Luděk Eyer ◽  
Daniel Růžek ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Virulent Strain ◽  
Encephalitis Virus ◽  
Antiviral Therapies ◽  
Tick Borne Encephalitis ◽  
Tbev Strain ◽  
Ic50 Values ◽  
Tick Borne Encephalitis Virus ◽  
Derivatives Of ◽  
Deoxy Sugars

Tick-borne encephalitis virus (TBEV) is a causative agent of tick-borne encephalitis (TBE), one of the most important human infections involving the central nervous system. Although effective vaccines are available on the market, they are recommended only in endemic areas. Despite many attempts, there are still no specific antiviral therapies for TBEV treatment. Previously, we synthesized a series of uridine derivatives of 2-deoxy sugars and proved that some compounds show antiviral activity against viruses from the Flaviviridae and Orthomyxoviridae families targeting the late steps of the N-glycosylation process, affecting the maturation of viral proteins. In this study, we evaluated a series of uridine derivatives of 2-deoxy sugars for their antiviral properties against two strains of the tick-borne encephalitis virus; the highly virulent TBEV strain Hypr and the less virulent strain Neudoerfl. Four compounds (2, 4, 10, and 11) showed significant anti-TBEV activity with IC50 values ranging from 1.4 to 10.2 µM and low cytotoxicity. The obtained results indicate that glycosylation inhibitors, which may interact with glycosylated membrane TBEV E and prM proteins, might be promising candidates for future antiviral therapies against TBEV.

Sign in / Sign up

Export Citation Format

Share Document