Advances in Anti-Tumor Nanomedicine based on Functional Metal Organic Frameworks beyond Drug Carriers

2022 ◽  
Author(s):  
Qin Wei ◽  
Yihan Wu ◽  
Fangfang Liu ◽  
Jiao Cao ◽  
Jinliang Liu
Keyword(s):  
Porous Structure ◽  
Drug Loading ◽  
Metal Organic Frameworks ◽  
Structural Diversity ◽  
Drug Carriers ◽  
Loading Capacity ◽  
High Drug ◽  
Metal Organic ◽  
Widespread Interest ◽  
High Drug Loading

Nanoscale metal-organic frameworks (MOFs) have attracted widespread interest due to the unique properties including tunable porous structure, high drug loading capacity, structural diversity, and outstanding biocompatibility. MOFs have been extensively...

Hollow structural metal–organic frameworks exhibit high drug loading capacity, targeted delivery and magnetic resonance/optical multimodal imaging

2019 ◽  
Vol 48 (46) ◽  
pp. 17291-17297 ◽  
Author(s):  
Xuechuan Gao ◽  
Ruixue Cui ◽  
Lijun Song ◽  
Zhiliang Liu
Keyword(s):  
Magnetic Resonance ◽  
Targeted Delivery ◽  
Multimodal Imaging ◽  
Drug Loading ◽  
Loading Capacity ◽  
Resonance Imaging ◽  
High Drug ◽  
Imaging Capability ◽  
Metal Organic ◽  
High Drug Loading

The obtained Fe-MOF-5-NH2-FA-5-FAM/5-FU in this work shows high drug loading ability and excellent fluorescence and magnetic resonance imaging capability.

Nanoscale covalent organic frameworks as smart carriers for drug delivery

2016 ◽  
Vol 52 (22) ◽  
pp. 4128-4131 ◽  
Author(s):  
Linyi Bai ◽  
Soo Zeng Fiona Phua ◽  
Wei Qi Lim ◽  
Avijit Jana ◽  
Zhong Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Loading ◽  
Drug Carriers ◽  
Loading Capacity ◽  
Covalent Organic Frameworks ◽  
High Drug ◽  
Good Biocompatibility ◽  
High Drug Loading

Two nanoscale covalent organic frameworks as drug carriers with good biocompatibility were developed, showing high drug loading capacity and sustained release in vitro.

A versatile and multifunctional metal–organic framework nanocomposite toward chemo-photodynamic therapy

2020 ◽  
Vol 49 (16) ◽  
pp. 5291-5301 ◽  
Author(s):  
Ying Pan ◽  
Zhidong Luo ◽  
Xiaoxiong Wang ◽  
Qianyi Chen ◽  
Junhao Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Metal Organic ◽  
Hybrid Scaffolds ◽  
High Drug Loading ◽  
Organic Framework

We synthesize a new carrier of ALA@UIO-66-NH-FAM/MTA to achieve efficient synergistic therapy, taking advantage of the targeting component of MTA and high drug-loading capacity of hybrid scaffolds of MOF.

scholarly journals Metal Organic Framework@Polysilsesequioxane Core/Shell-Structured Nanoplatform for Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 98
Author(s):  
Liangyu Lu ◽  
Mengyu Ma ◽  
Chengtao Gao ◽  
Hongwei Li ◽  
Long Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Surface Area ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
Loading Capacity ◽  
High Drug ◽  
Metal Organic ◽  
High Drug Loading

Modern pharmaceutics requires novel drug loading platforms with high drug loading capacity, controlled release, high stability, and good biocompacity. Metal–organic frameworks (MOFs) show promising applications in biomedicine owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs have low stability due to weak coordinate bonding and limited biocompatibility, limiting their bioapplication. In this study, we fabricated MOFs/polysilsesquioxane (PSQ) nanocomposites and utilized them as drug carriers. Amine-functionalized MOF (UiO-66-NH2) nanoparticles were synthesized and encapsulated with epoxy-functionalized polysilsesquioxane layer on the surface via a facile process. MOFs possessed high surface area and regular micropores, and PSQs offered stability, inertness, and functionality. The obtained UiO-66-NH2@EPSQ nanocomposites were utilized as carriers for ibuprofen, a drug with carboxylic groups on the surface, and demonstrated high drug loading capacity and well-controlled release property. The UiO-66-NH2@EPSQ nanocomposite exhibited low cytotoxicity to HeLa cells within a wide concentration range of 10–100 µg/mL, as estimated by the MTT method. The UiO-66-NH2@EPSQ drug release system could be a potential platform in the field of controlled drug delivery.

Design of dual-responsive nanocarries with high drug loading capacity based on hollow mesoporous organosilica nanoparticles

2019 ◽  
Vol 233 ◽  
pp. 230-235 ◽  
Author(s):  
Li-li Lu ◽  
Wen-ya Xiong ◽  
Jun-bin Ma ◽  
Tian-fang Gao ◽  
Si-yuan Peng ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Dual Responsive ◽  
Mesoporous Organosilica ◽  
High Drug Loading

scholarly journals Cancer Nanomedicines Stabilized by π-π Stacking between Heterodimeric Prodrugs Enable Exceptionally High Drug Loading Capacity and Safer Delivery of Drug Combinations

Theranostics ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 3638-3652 ◽  
Author(s):  
Hangxiang Wang ◽  
Jianmei Chen ◽  
Chang Xu ◽  
Linlin Shi ◽  
Munire Tayier ◽  
...  
Keyword(s):  
Drug Loading ◽  
Drug Combinations ◽  
Loading Capacity ◽  
High Drug ◽  
Π Stacking ◽  
High Drug Loading

A γ-cyclodextrin-based metal–organic framework embedded with graphene quantum dots and modified with PEGMA via SI-ATRP for anticancer drug delivery and therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (43) ◽  
pp. 20956-20967 ◽  
Author(s):  
Qiaojuan Jia ◽  
Zhenzhen Li ◽  
Chuanpan Guo ◽  
Xiaoyu Huang ◽  
Yingpan Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Graphene Quantum Dots ◽  
Tumor Growth Inhibition ◽  
High Drug ◽  
Anticancer Drug Delivery ◽  
Metal Organic ◽  
High Drug Loading

A biocompatible γ-CD-MOF based DDS with high drug loading and full drug release was prepared and effective tumor growth inhibition was achieved in vivo.

scholarly journals Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

RSC Advances ◽  
2019 ◽  
Vol 9 (61) ◽  
pp. 35566-35578 ◽  
Author(s):  
Subhankar Mukhopadhyay ◽  
Hanitrarimalala Veroniaina ◽  
Tadious Chimombe ◽  
Lidong Han ◽  
Wu Zhenghong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
High Drug Loading

Protean mesoporous silica nanoparticles are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including changeable pore size, mesoporosity, high drug loading capacity and biodegradability.

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