A versatile and multifunctional metal–organic framework nanocomposite toward chemo-photodynamic therapy

2020 ◽  
Vol 49 (16) ◽  
pp. 5291-5301 ◽  
Author(s):  
Ying Pan ◽  
Zhidong Luo ◽  
Xiaoxiong Wang ◽  
Qianyi Chen ◽  
Junhao Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Metal Organic ◽  
Hybrid Scaffolds ◽  
High Drug Loading ◽  
Organic Framework

We synthesize a new carrier of ALA@UIO-66-NH-FAM/MTA to achieve efficient synergistic therapy, taking advantage of the targeting component of MTA and high drug-loading capacity of hybrid scaffolds of MOF.

A γ-cyclodextrin-based metal–organic framework embedded with graphene quantum dots and modified with PEGMA via SI-ATRP for anticancer drug delivery and therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (43) ◽  
pp. 20956-20967 ◽  
Author(s):  
Qiaojuan Jia ◽  
Zhenzhen Li ◽  
Chuanpan Guo ◽  
Xiaoyu Huang ◽  
Yingpan Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Graphene Quantum Dots ◽  
Tumor Growth Inhibition ◽  
High Drug ◽  
Anticancer Drug Delivery ◽  
Metal Organic ◽  
High Drug Loading

A biocompatible γ-CD-MOF based DDS with high drug loading and full drug release was prepared and effective tumor growth inhibition was achieved in vivo.

Reversing tumor multidrug resistance with a catalytically active covalent organic framework

2021 ◽  
Author(s):  
Peng Gao ◽  
Teng Zheng ◽  
Bingjie Cui ◽  
Xiaohan Liu ◽  
Wei Pan ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Covalent Organic Framework ◽  
Catalytic Sites ◽  
Catalytically Active ◽  
High Drug Loading ◽  
Organic Framework

We report here a catalytically active nano covalent organic framework [COF(Fe)] with high drug loading capacity for reversing tumor multidrug resistance (MDR). The Fe catalytic sites in COF(Fe) could convert...

Hollow structural metal–organic frameworks exhibit high drug loading capacity, targeted delivery and magnetic resonance/optical multimodal imaging

2019 ◽  
Vol 48 (46) ◽  
pp. 17291-17297 ◽  
Author(s):  
Xuechuan Gao ◽  
Ruixue Cui ◽  
Lijun Song ◽  
Zhiliang Liu
Keyword(s):  
Magnetic Resonance ◽  
Targeted Delivery ◽  
Multimodal Imaging ◽  
Drug Loading ◽  
Loading Capacity ◽  
Resonance Imaging ◽  
High Drug ◽  
Imaging Capability ◽  
Metal Organic ◽  
High Drug Loading

The obtained Fe-MOF-5-NH2-FA-5-FAM/5-FU in this work shows high drug loading ability and excellent fluorescence and magnetic resonance imaging capability.

Advances in Anti-Tumor Nanomedicine based on Functional Metal Organic Frameworks beyond Drug Carriers

2022 ◽  
Author(s):  
Qin Wei ◽  
Yihan Wu ◽  
Fangfang Liu ◽  
Jiao Cao ◽  
Jinliang Liu
Keyword(s):  
Porous Structure ◽  
Drug Loading ◽  
Metal Organic Frameworks ◽  
Structural Diversity ◽  
Drug Carriers ◽  
Loading Capacity ◽  
High Drug ◽  
Metal Organic ◽  
Widespread Interest ◽  
High Drug Loading

Nanoscale metal-organic frameworks (MOFs) have attracted widespread interest due to the unique properties including tunable porous structure, high drug loading capacity, structural diversity, and outstanding biocompatibility. MOFs have been extensively...

Nontoxic and renewable metal–organic framework based on α-cyclodextrin with efficient drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (86) ◽  
pp. 82977-82983 ◽  
Author(s):  
Jing-Quan Sha ◽  
Xiao-Hua Zhong ◽  
Lian-He Wu ◽  
Guo-Dong Liu ◽  
Ning Sheng
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Loading Capacity ◽  
Left Handed ◽  
Metal Organic ◽  
Organic Framework

Two new nontoxic α-CD based compounds were synthesized by different method, which contain different left-handed helix and exhibit efficient drug loading capacity and sustained release behaviors.

scholarly journals Metal Organic Framework@Polysilsesequioxane Core/Shell-Structured Nanoplatform for Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 98
Author(s):  
Liangyu Lu ◽  
Mengyu Ma ◽  
Chengtao Gao ◽  
Hongwei Li ◽  
Long Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Surface Area ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
Loading Capacity ◽  
High Drug ◽  
Metal Organic ◽  
High Drug Loading

Modern pharmaceutics requires novel drug loading platforms with high drug loading capacity, controlled release, high stability, and good biocompacity. Metal–organic frameworks (MOFs) show promising applications in biomedicine owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs have low stability due to weak coordinate bonding and limited biocompatibility, limiting their bioapplication. In this study, we fabricated MOFs/polysilsesquioxane (PSQ) nanocomposites and utilized them as drug carriers. Amine-functionalized MOF (UiO-66-NH2) nanoparticles were synthesized and encapsulated with epoxy-functionalized polysilsesquioxane layer on the surface via a facile process. MOFs possessed high surface area and regular micropores, and PSQs offered stability, inertness, and functionality. The obtained UiO-66-NH2@EPSQ nanocomposites were utilized as carriers for ibuprofen, a drug with carboxylic groups on the surface, and demonstrated high drug loading capacity and well-controlled release property. The UiO-66-NH2@EPSQ nanocomposite exhibited low cytotoxicity to HeLa cells within a wide concentration range of 10–100 µg/mL, as estimated by the MTT method. The UiO-66-NH2@EPSQ drug release system could be a potential platform in the field of controlled drug delivery.

scholarly journals Microwave-Assisted Synthesis, Characterization and Modeling of CPO-27-Mg Metal-Organic Framework for Drug Delivery

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 426
Author(s):  
Anton I. Kudelin ◽  
Konstantinos Papathanasiou ◽  
Vera Isaeva ◽  
Juergen Caro ◽  
Tapio Salmi ◽  
...  
Keyword(s):  
Density Functional ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Microwave Assisted Synthesis ◽  
Functional Theory ◽  
Microwave Assisted ◽  
The Density Functional Theory ◽  
Metal Organic ◽  
High Drug Loading ◽  
Organic Framework

The coordination polymer CPO-27-Mg was rapidly synthesized under microwave irradiation. This material exhibits a sufficiently high drug loading towards aspirin (~8% wt.) and paracetamol (~14% wt.). The binding of these two molecules with the inner surface of the metal-organic framework was studied employing the Gaussian and Plane Wave approach of the Density Functional Theory. The structure of CPO-27-Mg persists after the adsorption of aspirin or paracetamol and their desorption energies, being quite high, decrease under solvent conditions.

Design of dual-responsive nanocarries with high drug loading capacity based on hollow mesoporous organosilica nanoparticles

2019 ◽  
Vol 233 ◽  
pp. 230-235 ◽  
Author(s):  
Li-li Lu ◽  
Wen-ya Xiong ◽  
Jun-bin Ma ◽  
Tian-fang Gao ◽  
Si-yuan Peng ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Dual Responsive ◽  
Mesoporous Organosilica ◽  
High Drug Loading

scholarly journals Histidine polypeptide-hybridized nanoscale metal–organic framework to sense drug loading/release

2021 ◽  
Vol 205 ◽  
pp. 109741
Author(s):  
Yanan Xu ◽  
Zhenhua Li ◽  
Dan Xiu ◽  
Guotao Sun ◽  
Christopher D. Snow ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Drug Loading ◽  
Metal Organic ◽  
Organic Framework
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