4D Printing in Biomedical Applications: Emerging Trends and Technologies

2021 ◽  
Author(s):  
Tarun Agarwal ◽  
Sung Yun Hann ◽  
Irene Chiesa ◽  
Haitao Cui ◽  
Nehar Celikkin ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Complex Structures ◽  
4D Printing ◽  
Environmental Stimuli ◽  
Emerging Trends ◽  
Material Systems

Nature's material systems during evolution have developed the ability to respond and adapt to environmental stimuli through the generation of complex structures capable of varying their functions across the direction,...

scholarly journals Biomedical applications of dendritic fibrous nanosilica (DFNS): recent progress and challenges

RSC Advances ◽  
2020 ◽  
Vol 10 (61) ◽  
pp. 37116-37133
Author(s):  
Mina Shaban ◽  
Mohammad Hasanzadeh
Keyword(s):  
Biomedical Applications ◽  
Recent Progress ◽  
Complex Structures ◽  
Significant Attention

Dendritic fibrous nanosilica (DFNS) , with multi-component and hierarchically complex structures, has recently been receiving significant attention in various fields of nano-biomedicine.

scholarly journals 4D Printing: A Review on Recent Progresses

Micromachines ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 796 ◽  
Author(s):  
Honghui Chu ◽  
Wenguang Yang ◽  
Lujing Sun ◽  
Shuxiang Cai ◽  
Rendi Yang ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
3D Printing ◽  
Three Dimensional ◽  
Complex Structures ◽  
Future Prospects ◽  
4D Printing ◽  
Stimulation Method ◽  
Shape Property ◽  
External Stimuli

Since the late 1980s, additive manufacturing (AM), commonly known as three-dimensional (3D) printing, has been gradually popularized. However, the microstructures fabricated using 3D printing is static. To overcome this challenge, four-dimensional (4D) printing which defined as fabricating a complex spontaneous structure that changes with time respond in an intended manner to external stimuli. 4D printing originates in 3D printing, but beyond 3D printing. Although 4D printing is mainly based on 3D printing and become an branch of additive manufacturing, the fabricated objects are no longer static and can be transformed into complex structures by changing the size, shape, property and functionality under external stimuli, which makes 3D printing alive. Herein, recent major progresses in 4D printing are reviewed, including AM technologies for 4D printing, stimulation method, materials and applications. In addition, the current challenges and future prospects of 4D printing were highlighted.

4D printing soft robotics for biomedical applications

2020 ◽  
Vol 36 ◽  
pp. 101567 ◽  
Author(s):  
Sung Yun Hann ◽  
Haitao Cui ◽  
Margaret Nowicki ◽  
Lijie Grace Zhang
Keyword(s):  
Biomedical Applications ◽  
Soft Robotics ◽  
4D Printing

scholarly journals Stem cell-laden hydrogel bioink for generation of high resolution and fidelity engineered tissues with complex geometries

2021 ◽  
Author(s):  
Oju Jeon ◽  
Yu Bin Lee ◽  
Sang Jin Lee ◽  
Nazilya Guliyeva ◽  
Joanna Lee ◽  
...  
Keyword(s):  
Stem Cell ◽  
High Resolution ◽  
Biomedical Applications ◽  
Human Mesenchymal Stem Cells ◽  
Complex Geometries ◽  
Complex Structures ◽  
Self Healing ◽  
3D Bioprinting ◽  
Healing Property

Recently, 3D bioprinting has been explored as a promising technology for biomedical applications with the potential to create complex structures with precise features. Cell encapsulated hydrogels composed of materials such as gelatin, collagen, hyaluronic acid, alginate and polyethylene glycol have been widely used as bioinks for 3D bioprinting. However, since most hydrogel-based bioinks may not allow rapid stabilization immediately after 3D bioprinting, achieving high resolution and fidelity to the intended architecture is a common challenge in 3D bioprinting of hydrogels. In this study, we have utilized shear-thinning and self-healing ionically crosslinked oxidized and methacrylated alginates (OMAs) as a bioink, which can be rapidly gelled by its self-healing property after bioprinting and further stabilized via secondary crosslinking. It was successfully demonstrated that stem cell-laden calcium-crosslinked OMA hydrogels can be bioprinted into complicated 3D tissue structures with both high resolution and fidelity. Additional photocrosslinking enables long-term culture of 3D bioprinted constructs for formation of functional tissue by differentiation of encapsulated human mesenchymal stem cells.

scholarly journals 4D Printing Self-Morphing Structures

Materials ◽  
2019 ◽  
Vol 12 (8) ◽  
pp. 1353 ◽  
Author(s):  
Mahdi Bodaghi ◽  
Reza Noroozi ◽  
Ali Zolfagharian ◽  
Mohamad Fotouhi ◽  
Saeed Norouzi
Keyword(s):  
Composite Structures ◽  
Fused Deposition Modeling ◽  
Functionally Graded ◽  
Complex Structures ◽  
Mechanical Behaviors ◽  
4D Printing ◽  
Digital Tool ◽  
Fused Deposition ◽  
Straightforward Method ◽  
Deposition Modeling

The main objective of this paper is to introduce complex structures with self-bending/morphing/rolling features fabricated by 4D printing technology, and replicate their thermo-mechanical behaviors using a simple computational tool. Fused deposition modeling (FDM) is implemented to fabricate adaptive composite structures with performance-driven functionality built directly into materials. Structural primitives with self-bending 1D-to-2D features are first developed by functionally graded 4D printing. They are then employed as actuation elements to design complex structures that show 2D-to-3D shape-shifting by self-bending/morphing. The effects of printing speed on the self-bending/morphing characteristics are investigated in detail. Thermo-mechanical behaviors of the 4D-printed structures are simulated by introducing a straightforward method into the commercial finite element (FE) software package of Abaqus that is much simpler than writing a user-defined material subroutine or an in-house FE code. The high accuracy of the proposed method is verified by a comparison study with experiments and numerical results obtained from an in-house FE solution. Finally, the developed digital tool is implemented to engineer several practical self-morphing/rolling structures.

Two-Dimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects

2015 ◽  
Vol 27 (45) ◽  
pp. 7261-7284 ◽  
Author(s):  
David Chimene ◽  
Daniel L. Alge ◽  
Akhilesh K. Gaharwar
Keyword(s):  
Biomedical Applications ◽  
Two Dimensional ◽  
Future Prospects ◽  
Emerging Trends

3D polymeric scaffolds towards biomedical applications

2020 ◽  
Author(s):  
◽  
Cheng Zhang
Keyword(s):  
Transition Temperature ◽  
Body Temperature ◽  
Shape Memory ◽  
Biomedical Applications ◽  
Electronic Devices ◽  
4D Printing ◽  
Device Structure ◽  
3D Structures ◽  
New Device ◽  
Polymeric Scaffolds

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] How can research on mechanical engineering and materials science contribute to human health? The fabrication of biomedical scaffolds could be a good entry point. Scaffolds are broadly applied in biomedical fields with multiple functions, such as repair, replacement, and stimulation and monitoring when they are integrated with electronic/optoelectronic devices. Besides biocompatible, the scaffolds should be soft and in form of three-dimensional (3D) structures in order to mechanically and geometrically match the natural tissues and organs. Polymers are the most promising candidate materials for the scaffold fabrication. Compared to metals and ceramics, substantial polymers have biocompatibility and all of them have low Young's modulus and high processability. Benefiting from the high processability, a variety of approaches can be used to shape polymeric scaffolds with 3D architectures. The major three approaches are flexibility, stress induced assembly, and printing. However, none of them is flawless: (1) For flexibility, the scaffolds that integrated with electronic devices have large thickness which exponentially lower the flexibility. (2) For stress-induced assembly, the assembly operation requires complicated actuation equipment and the assembled scaffolds are usually tethered on cumbersome elastomeric substrates. (3) For printing, few of scaffolds fabricated by emerging 4D printing technologies are responsive to biocompatible stimuli. This dissertation aims at addressing these three problems. First, a new device structure, i.e., lateral electrode, is proposed to reduce the thickness and then improve the flexibility of the scaffolds with electronics, which is validated by fabricating flexible photodetectors on polyimide substrates. The photodetectors have excellent flexibility and can be bent to 3D structures. Second, a new stress-induced assembly strategy, i.e., responsive buckling, is developed in which the elastomeric substrates are replaced with deft responsive polymeric substrates. Various 3D polymeric scaffolds either with or without electronic devices are assembled when the substrates are exposed to external stimuli without manual intervention. This strategy is first verified by an acetone responsive organogel and then developed toward biomedical applications by using a body temperature responsive hydrogel. Third, a new shape memory polymer, i.e., poly (glycerol dodecanoate) acrylate (PGDA), whose transition temperature is in the range of 20-37 [degrees]C, is exploited for 4D printing of scaffolds. Because of the propriate transition temperature, the shape memory process of the scaffolds can be completed by using room temperature and body temperature as stimuli, which are harmless for human body. Moreover, a variety of delicate 3D structures including an artery-like tube are printed.

4D Printing and Its Biomedical Applications

2018 ◽  
pp. 343-372 ◽  
Author(s):  
Saeed Akbari ◽  
Yuan-Fang Zhang ◽  
Dong Wang ◽  
Qi Ge
Keyword(s):  
Biomedical Applications ◽  
4D Printing

Self-Assembly in Peptides Containing β-and γ-amino Acids

2020 ◽  
Vol 21 (6) ◽  
pp. 584-597
Author(s):  
Sudha Shankar ◽  
Junaid Ur Rahim ◽  
Rajkishor Rai
Keyword(s):  
Amino Acids ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Building Blocks ◽  
Secondary Structures ◽  
Complex Structures

The peptides containing β-and γ-amino acids as building blocks display well-defined secondary structures with unique morphologies. The ability of such peptides to self-assemble into complex structures of controlled geometries has been exploited in biomedical applications. Herein, we have provided an updated overview about the peptides containing β-and γ-amino acids considering the significance and advancement in the area of development of peptide-based biomaterials having diverse applications.

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