scholarly journals Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders

2019 ◽  
Vol 6 (10) ◽  
pp. 1956-1973 ◽  
Author(s):  
Liane I. F. Moura ◽  
Alessio Malfanti ◽  
Carina Peres ◽  
Ana I. Matos ◽  
Elise Guegain ◽  
...  
Keyword(s):  
Immune System ◽  
Infectious Diseases ◽  
Physicochemical Properties ◽  
Delivery Systems ◽  
Branched Polymers ◽  
Immune Disorders ◽  
System P ◽  
Immunomodulatory Properties

The review focus on branched polymers as promising delivery systems with immunomodulatory properties against cancer and infectious diseases. It covers their physicochemical properties and on how those can be tailored to modulate the immune system.

The role of morphology, shell composition and protein corona formation in Au/Fe3O4 composite nanoparticle mediated macrophage responses

2021 ◽  
Author(s):  
Lihua He ◽  
Kang Ma ◽  
Xiaonan Liu ◽  
Huixia Li ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Immune System ◽  
Physicochemical Properties ◽  
Biomedical Applications ◽  
Protein Corona ◽  
System P ◽  
Corona Formation ◽  
Composite Nanoparticle ◽  
Shell Composition

The great interest in using nanoparticles (NPs) for biomedical applications is transversal to various materials despite the poorly understood correlation between their physicochemical properties and effects on the immune system....

Nutritional Recommendation for COVID-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 753-757
Author(s):  
Anagha Gulhane ◽  
Shamli Hiware
Keyword(s):  
Immune System ◽  
Global Health ◽  
Infectious Diseases ◽  
Immune Function ◽  
The Body ◽  
Health Issue ◽  
System Quality ◽  
Life Phase ◽  
Global Health Issue ◽  
Nutritional Recommendation

It is the most unreliable truth that anybody can get infected by the COVID-19, and nobody can escape from the danger of getting tainted by the virus. Yet, the line of hope is that anyone and everyone can boost their resistance, thus avoid the risk of getting affected by the illness. The immunity of humans pulls down as they grow older. If their immune system is robust, them falling sick is feeble. If their resistance is weak, them getting ill is sound. Several factors affect the immune system and its ability, including its nourishment. A two-way connection between nutrition, infection and immunity presents. Changes in one part will affect the others part in our body that's the nature's rule. Well defined immune system quality which is present between each life phase may influence the type, generality and the degree of infections. At the same time, low nutrition to the body will decrease the immune function and expose the body to the danger of getting infected by infectious diseases. Different quantity of micronutrients is required for increasing the immunity power of our body. Generally the vitamins A,C,D,E,B2,B6,B12, iron, zinc and selenium.The deficiencies of micronutrients are acknowledged as a global health issue, and also low nutrition makes it prone to establishes the infections in the body.

scholarly journals Application of 3D bioprinting in the prevention and the therapy for human diseases

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Hee-Gyeong Yi ◽  
Hyeonji Kim ◽  
Junyoung Kwon ◽  
Yeong-Jin Choi ◽  
Jinah Jang ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Rapid Development ◽  
In Vitro Models ◽  
Delivery Systems ◽  
Advanced Technology ◽  
3D Bioprinting ◽  
Disease Research ◽  
Infectious Disease Research

AbstractRapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery systems. In this regard, layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease research. In addition, the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines, therapeutics, and relevant delivery systems. Herein, we discuss the potential of 3D bioprinting technologies for the control of infectious diseases. We also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.

scholarly journals On the modeling of the interaction between tumor growth and the immune system using some new fractional and fractional-fractal operators

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Behzad Ghanbari
Keyword(s):  
Immune System ◽  
Infectious Diseases ◽  
Tumor Growth ◽  
Computational Models ◽  
Recent Literature ◽  
Approximate Solutions ◽  
Biological Phenomena ◽  
Uniqueness Of The Solution ◽  
Biological Concepts ◽  
New Research

Abstract Humans are always exposed to the threat of infectious diseases. It has been proven that there is a direct link between the strength or weakness of the immune system and the spread of infectious diseases such as tuberculosis, hepatitis, AIDS, and Covid-19 as soon as the immune system has no the power to fight infections and infectious diseases. Moreover, it has been proven that mathematical modeling is a great tool to accurately describe complex biological phenomena. In the recent literature, we can easily find that these effective tools provide important contributions to our understanding and analysis of such problems such as tumor growth. This is indeed one of the main reasons for the need to study computational models of how the immune system interacts with other factors involved. To this end, in this paper, we present some new approximate solutions to a computational formulation that models the interaction between tumor growth and the immune system with several fractional and fractal operators. The operators used in this model are the Liouville–Caputo, Caputo–Fabrizio, and Atangana–Baleanu–Caputo in both fractional and fractal-fractional senses. The existence and uniqueness of the solution in each of these cases is also verified. To complete our analysis, we include numerous numerical simulations to show the behavior of tumors. These diagrams help us explain mathematical results and better describe related biological concepts. In many cases the approximate results obtained have a chaotic structure, which justifies the complexity of unpredictable and uncontrollable behavior of cancerous tumors. As a result, the newly implemented operators certainly open new research windows in further computational models arising in the modeling of different diseases. It is confirmed that similar problems in the field can be also be modeled by the approaches employed in this paper.

Mice gut microbiota programming by using the infant food profile. The effect on growth, gut microbiota and the immune system

2017 ◽  
Vol 8 (10) ◽  
pp. 3758-3768 ◽  
Author(s):  
Elvira Sánchez-Samper ◽  
Carlos Gómez-Gallego ◽  
Pedro Andreo-Martínez ◽  
Seppo Salminen ◽  
Gaspar Ros
Keyword(s):  
Immune System ◽  
Gut Microbiota ◽  
Infant Food ◽  
System P ◽  
Effect On Growth

Infant food profile on programming of the growth, gut microbiota and immune system of C57BL/6J mice.

scholarly journals INTRODUCTION: Immune Relevant Animal Models: Opportunities and Challenges

ILAR Journal ◽  
2018 ◽  
Vol 59 (3) ◽  
pp. 209-210
Author(s):  
Gregers Jungersen ◽  
Jorge Piedrahita
Keyword(s):  
Immune System ◽  
T Cell ◽  
Animal Models ◽  
Infectious Diseases ◽  
Tissue Specific ◽  
Car T Cell ◽  
Car T ◽  
Preclinical Animal Models

Abstract Valid interpretation of preclinical animal models in immunology-related clinical challenges is important to solve outstanding clinical needs. Given the overall complexity of the immune system and both species- and tissue-specific immune peculiarities, the selection and design of appropriate immune-relevant animal models is, however, not following a straightforward path. The topics in this issue of the ILAR Journal provide assessments of immune-relevant animal models used in oncology, hematopoietic-, CAR-T cell- and xenotransplantation, adjuvants and infectious diseases, and immune privileged inflammation that are providing key insights into unmet human clinical needs.

Oral Administration of Lipid-Based Delivery Systems to Combat Infectious Diseases

2018 ◽  
pp. 75-110
Author(s):  
Rita M. Pinto ◽  
Daniela Lopes ◽  
Cláudia Nunes ◽  
Bruno Sarmento ◽  
Salette Reis
Keyword(s):  
Infectious Diseases ◽  
Oral Administration ◽  
Delivery Systems

scholarly journals The role of nutrition in strengthening immune system against newly emerging viral diseases: case of SARS-CoV-2

2020 ◽  
Vol 4 (7) ◽  
pp. 240-244
Author(s):  
Meghit Boumediene Khaled ◽  
Nada Benajiba
Keyword(s):  
Immune System ◽  
Infectious Diseases ◽  
Nutritional Status ◽  
Infected Individual ◽  
Emerging Infectious Diseases ◽  
The Body ◽  
Healthy Diet ◽  
World Health ◽  
Viral Diseases ◽  
Prevention Measures

The immune system is involved in the protection of host against environmental agents such as pathogenic micro-organisms (bacteria, fungi, and viruses) and chemicals, thereby preserving the integrity of the body. To preserve organism defense mechanisms, adequate nutritional status should be maintained with appropriate intakes of calories, vitamins, minerals and water that should be continuously provided by a healthy diet. The emergence of new infectious diseases with new pathogenic properties constitutes a serious health issue worldwide. Severe acute respiratory syndrome (SARS) represents one of the most recent emerging infectious diseases, caused by a novel coronavirus member called (SARS-CoV-2), identified in Wuhan, Hubei, China in December 2019, and recognized as pandemic by the World Health Organization (WHO). The nutritional status of each COVID-19-infected patient should be assessed prior undertaking treatments. Nutritional support should be the basis of management of any infected individual. However, prevention measures remain the first priority and strategy to develop throughout proper hygiene, healthy diet and staying home. Keywords: Nutrition, Immune system, Viral diseases, SARS-CoV-2.

scholarly journals Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases

2021 ◽  
Vol 22 (23) ◽  
pp. 13009
Author(s):  
Xi-Dian Tang ◽  
Tian-Tian Ji ◽  
Jia-Rui Dong ◽  
Hao Feng ◽  
Feng-Qiang Chen ◽  
...  
Keyword(s):  
Immune System ◽  
Infectious Diseases ◽  
Targeted Therapies ◽  
Tissue Damage ◽  
Systemic Infection ◽  
Therapeutic Strategies ◽  
Targeted Treatment ◽  
Cytokine Storm ◽  
Pathophysiological Mechanisms ◽  
Circulating Cytokines

Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, “multi-omics” immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.

scholarly journals Therapeutic potential of exosomes and their derivatives

2018 ◽  
pp. 129-131
Author(s):  
И.Ю. Малышев ◽  
Л.В. Кузнецова ◽  
О.П. Буданова
Keyword(s):  
Drug Delivery ◽  
Immune System ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Delivery Systems ◽  
Current Data ◽  
Natural Origin ◽  
Advantages And Disadvantages ◽  
Efficient Delivery ◽  
Synthetic Drug

В обзоре представлены современные данные о механизмах диагностики, планирования и оценки успешности терапии различных заболеваний с помощью экзосом, об использовании их как нанопереносчиков (т.е. нановезикул для эффективной доставки молекул). За последние годы разработано большое количество разных, в основном синтетических, систем доставки лекарственных средств, недостатками этих систем является плохая биосовместимость и органическая неспособность к высокоточной доставке загруженных веществ. По сравнению с синтетическими системами доставки лекарственных средств, экзосомы - вследствие своего естественного происхождения - могут обладать большими преимуществами, такими, как лучшая биосовместимость и повышенная устойчивость к разрушительному воздействию иммунной системы. Описана технология производства наноструктур, разработка и производство с помощью бионанотехнологий так называемых «полностью синтетических экзосомоподобных нановезикул», преимущества и недостатки этих методов. This review presents current data on mechanisms for diagnosis, planning, and evaluation of success in the treatment of various diseases using exosomes as nanocarriers (i.e., nanovesicles for efficient delivery of molecules). In recent years, a large number of different, mainly synthetic drug delivery systems has been developed. Disadvantages of these systems are poor biocompatibility and organic inability to deliver high-precision loaded substances. Compared with synthetic drug delivery systems, exosomes due to their natural origin may provide great advantages, such as better biocompatibility and increased resistance to detrimental effects of the immune system. This review describes in detail a technology of nanostructure production, the development and production of so-called fully synthetic exosome-like nanovesicles using bionanotechnology, and advantages and disadvantages of these methods.

Sign in / Sign up

Export Citation Format

Share Document