Boronic Acid-Functionalized Spherical Polymer Brushes for Efficient and Selective Enrichment of Glycoproteins

2021 ◽  
Author(s):  
Chen Hua ◽  
Kaimin Chen ◽  
Xuhong Guo
Keyword(s):  
Boronic Acid ◽  
Polymer Brushes ◽  
Biological Activities ◽  
Selective Enrichment

Glycoproteins are related to many biological activities and diseases, thereby their efficient capture and enrichment for diagnostics and proteomics has emerged to exhibit great significance. However, the lack of materials...

Graphene oxide-based boronate polymer brushes via surface initiated atom transfer radical polymerization for the selective enrichment of glycoproteins

2016 ◽  
Vol 4 (36) ◽  
pp. 6125-6133 ◽  
Author(s):  
Xiangyang An ◽  
Xiwen He ◽  
Langxing Chen ◽  
Yukui Zhang
Keyword(s):  
Graphene Oxide ◽  
Atom Transfer Radical Polymerization ◽  
Radical Polymerization ◽  
Efficient Method ◽  
Biological Samples ◽  
Boronic Acid ◽  
Polymer Brushes ◽  
Atom Transfer ◽  
Magnetic Graphene Oxide ◽  
Selective Enrichment

A facile and efficient method was developed to synthesize boronic acid polymer brushes immobilized on magnetic graphene oxide for the selective enrichment of glycoproteins from complex biological samples via surface initiated atom transfer radical polymerization (SI-ATRP).

scholarly journals A Theoretical Model to Study the Interaction Between Boronic Acids and Insulin

2020 ◽  
Author(s):  
Durgesh Kumar ◽  
Kamlesh Kumari ◽  
PRASHANT SINGH
Keyword(s):  
Amino Acids ◽  
Theoretical Model ◽  
Boronic Acid ◽  
Significant Interaction ◽  
Biological Activities ◽  
Boronic Acids ◽  
Biological Molecules ◽  
Computational Tools ◽  
Medical Expertise ◽  
Stabilizing Agents

Boronic acids are widely used in various applications in view of their ability to recognize and bind at specific sites of the biological molecules to mimic several processes. Therefore, this has attracted the researchers, academician and medical expertise to explore them. In the present work, the authors have designed a theoretical approach to study the interaction of boronic acid with insulin using computational tools. A library of boronic acids (114 compounds) are designed, optimized and interacted with insulin using computational tools i.e. iGEMDOCK. Further, their different biological activities and toxicity are determined. Results indicates the promising potential of the boronic acids on interaction with the insulin. Amongst, 114 molecules of boronic acids, 3-Benzyloxyphenylboronic acid (71) showed the best interaction with amino-acids of insulin and significant interaction was shown with the Glu21 and His5 residues. Further, these results were compared with the stabilizing agents and found to be more potent.

scholarly journals Maltose-Functionalized Hydrophilic Magnetic Nanoparticles with Polymer Brushes for Highly Selective Enrichment of N-Linked Glycopeptides

ACS Omega ◽  
2018 ◽  
Vol 3 (2) ◽  
pp. 1572-1580 ◽  
Author(s):  
Changfen Bi ◽  
Yulu Liang ◽  
Lijin Shen ◽  
Shanshan Tian ◽  
Kai Zhang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Polymer Brushes ◽  
Selective Enrichment

Synthesis and Antibacterial Activities of Boronic Acid-Based Recyclable Spherical Polymer Brushes

2019 ◽  
Vol 27 (7) ◽  
pp. 640-648
Author(s):  
Hüseyin Cicek ◽  
Gökhan Kocak ◽  
Özgür Ceylan ◽  
Vural Bütün
Keyword(s):  
Boronic Acid ◽  
Polymer Brushes ◽  
Antibacterial Activities

Phenylboronic acid-functionalized core–shell magnetic composite nanoparticles as a novel protocol for selective enrichment of fructose from a fructose–glucose aqueous solution

2017 ◽  
Vol 41 (22) ◽  
pp. 13399-13407 ◽  
Author(s):  
Lei Gu ◽  
Yun Wang ◽  
Juan Han ◽  
Lei Wang ◽  
Xu Tang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Magnetic Nanoparticles ◽  
Boronic Acid ◽  
Phenylboronic Acid ◽  
Sample Solution ◽  
Core Shell ◽  
Magnetic Composite ◽  
Selective Enrichment ◽  
Functionalized Magnetic Nanoparticles ◽  
First Time

We developed an efficient and mild method for the preparation of boronic acid-functionalized magnetic nanoparticles (MNPs), and the selective separation of fructose from a sample solution was demonstrated for the first time.

Boronic acid functionalized fibrous cellulose for the selective enrichment of glycopeptides

2020 ◽  
Vol 43 (7) ◽  
pp. 1348-1355 ◽  
Author(s):  
Muhammad Salman Sajid ◽  
Fahmida Jabeen ◽  
Dilshad Hussain ◽  
Qurra‐tul‐Ann Afza Gardner ◽  
Muhammad Naeem Ashiq ◽  
...  
Keyword(s):  
Boronic Acid ◽  
Selective Enrichment ◽  
Fibrous Cellulose

Branched polyethyleneimine-assisted boronic acid-functionalized magnetic nanoparticles for the selective enrichment of trace glycoproteins

The Analyst ◽  
2017 ◽  
Vol 142 (23) ◽  
pp. 4494-4502 ◽  
Author(s):  
Daojin Li ◽  
Zijun Bie
Keyword(s):  
Magnetic Nanoparticles ◽  
Boronic Acid ◽  
Selective Enrichment ◽  
Functionalized Magnetic Nanoparticles ◽  
Extraction Separation ◽  
Boronate Affinity Materials

Boronate affinity materials, as efficient sorbents for extraction, separation and enrichment of glycoproteins, have attracted more and more attention in recent years.

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