scholarly journals Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics

2018 ◽  
Vol 6 (4) ◽  
pp. 746-765 ◽  
Author(s):  
Houjuan Zhu ◽  
Penghui Cheng ◽  
Peng Chen ◽  
Kanyi Pu
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Spatial Resolution ◽  
Photothermal Therapy ◽  
Normal Tissue ◽  
Recent Progress ◽  
Near Infrared ◽  
Tumor Ablation ◽  
Ablation Efficiency ◽  
Excellent Spatial Resolution

Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have gained considerable attention due to their high tumor ablation efficiency, excellent spatial resolution and minimal side effects on normal tissue.

A Near-Infrared Light-Excitable Immunomodulating Nano-photosensitizer for Effective Photoimmunotherapy

2021 ◽  
Author(s):  
Yadan Zheng ◽  
Zhanzhan Zhang ◽  
Qi Liu ◽  
Ying Wang ◽  
Jialei Hao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Immune Responses ◽  
Near Infrared ◽  
Tumor Ablation ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Therapeutic Efficiency ◽  
Immunosuppressive Tumor Microenvironment

Photodynamic therapy has great potential for tumor ablation and the activation of antitumor immune responses. However, its overall therapeutic efficiency is often limited by the immunosuppressive tumor microenvironment. We developed...

Phototherapy and multimodal imaging of cancers based on perfluorocarbon nanomaterials

2021 ◽  
Author(s):  
Zhaoguo Han ◽  
xianshuang tu ◽  
Lina Qiao ◽  
Yige Sun ◽  
Zibo Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Multimodal Imaging

Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT) possesses unique characteristics of non-invasiveness and minimal side effects in cancer treatment, compared with conventional therapies. However, the ubiquitous tumor...

Recent Progress in Near Infrared Light Triggered Photodynamic Therapy

Small ◽  
2017 ◽  
Vol 13 (44) ◽  
pp. 1702299 ◽  
Author(s):  
Kerong Deng ◽  
Chunxia Li ◽  
Shanshan Huang ◽  
Bengang Xing ◽  
Dayong Jin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Recent Progress ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light

A Near-Infrared Small Molecule Coupled with Rigidness and Flexibility for High-Performance Multimodal Imaging-Guided Photodynamic and Photothermal Synergistic Therapy

2021 ◽  
Author(s):  
Xiaozhen Li ◽  
Fang Fang ◽  
Bo Sun ◽  
Chao YIN ◽  
Jihua Tan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Application ◽  
Small Molecule ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
High Performance ◽  
Near Infrared ◽  
The Other ◽  
Lesion Site ◽  
Comprehensive Information

Photodynamic therapy (PDT) synergized photothermal therapy (PTT) shows superior clinical application prospect than single PDT or PTT. On the other hand, multimodal imaging can delineate comprehensive information of lesion site...

scholarly journals Effects and side effects of plasmonic photothermal therapy in brain tissue

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Yue He ◽  
Kristoffer Laugesen ◽  
Dana Kamp ◽  
Salik A. Sultan ◽  
Lene B. Oddershede ◽  
...  
Keyword(s):  
Side Effects ◽  
Brain Tissue ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Thermal Response ◽  
Local Environment ◽  
Plasmonic Nanoparticles ◽  
Correct Analysis ◽  
Bio Compatibility ◽  
Plasmonic Photothermal Therapy

Abstract Background Heat generated from plasmonic nanoparticles can be utilized in plasmonic photothermal therapy. A combination of near-infrared laser and plasmonic nanoparticles is compelling for the treatment of brain cancer, due to the efficient light-to-heat conversion and bio-compatibility. However, one of the challenges of plasmonic photothermal therapy is to minimize the damage of the surrounding brain tissue. The adjacent tissue can be damaged as a result of either absorption of laser light, thermal conductivity, nanoparticles diffusing from the tumor, or a combination hereof. Hence, we still lack the full understanding of the light–tissue interaction and, in particular, the thermal response. Results We tested the temperature change in three different porcine cerebral tissues, i.e., the stem, the cerebrum, and the cerebellum, under laser treatment. We find that the different tissues have differential optical and thermal properties and confirm the enhancement of heating from adding plasmonic nanoparticles. Furthermore, we measure the loss of laser intensity through the different cerebral tissues and stress the importance of correct analysis of the local environment of a brain tumor. Conclusions Our results stress the conclusion that a personalized analysis of the local environment is needed to balance the effect and side effects prior to plasmonic photothermal therapy.

scholarly journals Broad spectrum antibacterial photodynamic and photothermal therapy achieved with indocyanine green loaded SPIONs under near infrared irradiation

2020 ◽  
Vol 8 (16) ◽  
pp. 4616-4625 ◽  
Author(s):  
K. Bilici ◽  
N. Atac ◽  
A. Muti ◽  
I. Baylam ◽  
O. Dogan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Indocyanine Green ◽  
Broad Spectrum ◽  
Photothermal Therapy ◽  
Bacterial Infections ◽  
Near Infrared ◽  
Alternative Therapies ◽  
Antimicrobial Photodynamic Therapy ◽  
Infrared Irradiation ◽  
Antibiotic Resistant

Antimicrobial photodynamic therapy (aPDT) and antimicrobial photothermal therapy (aPTT) are promising local and effective alternative therapies for antibiotic resistant bacterial infections and biofilms.

Theranostics of Gold Nanoparticles with an Emphasis on Photoacoustic Imaging and Photothermal Therapy

2018 ◽  
Vol 24 (23) ◽  
pp. 2719-2728 ◽  
Author(s):  
Yi Liu ◽  
Wenhui Ma ◽  
Jing Wang
Keyword(s):  
Gold Nanoparticles ◽  
Temperature Control ◽  
Photothermal Therapy ◽  
Recent Progress ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Diagnosis And Treatment ◽  
Chemical Characteristics ◽  
Nir Light ◽  
Physical And Chemical

Gold nanoparticles (AuNPs) are promising biomedical agents in terms of both imaging and therapy, exhibiting excellent physical and chemical characteristics. The actions of AuNPs can be remotely controlled using strong near-infrared (NIR) light, associated with minimal lateral invasion. Employing the photoacoustic (PA) principle, AuNPs integrate imaging and temperature control, affording both diagnosis and treatment mediated by NIR light. We here review recent progress in the theranostic field employing AuNPs to both PA and photothermal ends.

scholarly journals Photoacoustic imaging and photothermal therapy in the second near-infrared window

2019 ◽  
Vol 43 (23) ◽  
pp. 8835-8851 ◽  
Author(s):  
Xiaoguang Ge ◽  
Qinrui Fu ◽  
Lin Bai ◽  
Bin Chen ◽  
Renjie Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Recent Progress ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Infrared Window

This review summarizes the recent progress of PA imaging and PTT agents in the second NIR window.

A Novel TMTP1-Modified Theranostic Nanoplatform for Targeted In Vivo NIR-II Fluorescence Imaging-Guided Chemotherapy of Cervical Cancer

2022 ◽  
Author(s):  
Nuernisha Alifu ◽  
Rong Ma ◽  
Lijun Zhu ◽  
Zhong Du ◽  
Shuang Chen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Fluorescence Imaging ◽  
Spatial Resolution ◽  
Biomedical Research ◽  
Near Infrared ◽  
High Sensitivity ◽  
Research Fields ◽  
Excellent Spatial Resolution ◽  
Fluorescence Bioimaging

Near-infrared II (NIR-II, 900-1700 nm) fluorescence bioimaging with advantages of good biosafety, excellent spatial resolution, high sensitivity, and contrast has attracted great attentions in biomedical research fields. However, most of...

scholarly journals A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation

2015 ◽  
Vol 6 (1) ◽  
pp. 798-803 ◽  
Author(s):  
Xuanjun Wu ◽  
Mingzhu Yu ◽  
Bijuan Lin ◽  
Hongjie Xing ◽  
Jiahuai Han ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Ablation ◽  
Ph Responsive ◽  
Signal Activation

A sialic acid-targeted near-infrared profluorophore with pH-responsive fluorescence and photothermal properties was developed for fluorescence-guided staging and photothermal therapy of viable tumors exposed during surgery.

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