A Metastasis Suppressor Pt-Dendrimer Nanozyme for the Alleviation of Glioblastoma

2021 ◽  
Author(s):  
Jong Min An ◽  
Youngwon Ju ◽  
Jeong Hee Kim ◽  
Hyein Lee ◽  
Yuna Jung ◽  
...  
Keyword(s):  
Translational Medicine ◽  
Basic Research ◽  
Cutting Edge ◽  
Metastasis Suppressor ◽  
Biological Applications ◽  
Enzymatic Characteristics ◽  
Natural Enzyme

Nanozymes are nanostructure-based materials which mimic the enzymatic characteristics of natural enzyme. Biological applications of nanozymes have been highlighted in basic research, industry, and translational medicine as a new cutting-edge...

scholarly journals A Roadmap to Gradually Compare and Benchmark Description Logic Calculi

10.29007/tgc4 ◽  
2019 ◽  
Author(s):  
Fred Freitas
Keyword(s):  
Asymptotic Analysis ◽  
Description Logic ◽  
Basic Research ◽  
Detailed Comparison ◽  
Optimization Techniques ◽  
Cutting Edge ◽  
Memory Usage ◽  
Inference Methods

DL reasoners were developed with cutting-edge performance, implementing plenty of specific optimization techniques over tableaux-based methods, which took over the field. However, promising methods may have been neglected in such a scenario, in which the tough competition is often focused on gains through optimizations. Therefore, perhaps there is still room available for “basic research” on DL reasoning. The purpose of this work is to stimulate research on trying out DL calculi other than tableaux. Such endeavors should be carried out by making a careful, detailed comparison between tableaux and other inference methods in a systematic way: first starting with simpler languages (like ALC) without any optimizations. Then gradually including optimizations and comparing them; and continuing these interactive steps: enhancing language expressivity, including optimizations, and testing until reaching the most expressive DL fragments such as SROIQ. The comparison can also be done by in terms memory usage and algorithm asymptotic analysis, with worst and average cases, etc. The rationale is identifying whether there are fragments which are more suitable to certain inference methods, as well as which aspects or constructs (e.g., the costliest combinations, which usually involve inverses, nominals, equalities, etc) are sensitive to which calculus.

scholarly journals CRISPR/Cas9‐mediated genome editing: From basic research to translational medicine

2020 ◽  
Vol 24 (7) ◽  
pp. 3766-3778 ◽  
Author(s):  
Filipe V. Jacinto ◽  
Wolfgang Link ◽  
Bibiana I. Ferreira
Keyword(s):  
Genome Editing ◽  
Translational Medicine ◽  
Basic Research

scholarly journals Swiss institute for translational and entrepreneurial medicine (sitem-insel)

2017 ◽  
Vol 1 (1) ◽  
pp. 2514183X1771410
Author(s):  
Felix J Frey
Keyword(s):  
Private Sector ◽  
Clinical Application ◽  
Translational Medicine ◽  
Continuing Professional Development ◽  
Basic Research ◽  
University Hospital ◽  
Non Profit ◽  
Private Sector Development ◽  
New Findings ◽  
Swiss Institute

sitem-insel – the Swiss Institute for Translational and Entrepreneurial Medicine in Bern – was created to establish, operate and develop a National Center of Excellence for Translational Medicine. sitem-insel is organized as a non-profit oriented public private partnership. Translational medicine is a new, process-oriented discipline that aims to translate new findings and products emerging from private-sector development and basic research into clinical application. The discipline seeks to professionalize the essential interaction between scientists conducting basic research in the private sector and universities, clinicians, regulatory bodies and investors. The mission of sitem-insel is to create and foster an enhanced environment for translational medicine in Switzerland. The sitem-insel strategy rests on three pillars: 1) The sitem-insel School offers university-level continuing professional development courses taught by university and private-sector lecturers. 2) The sitem-insel Enabling Facilities provide infrastructure to foster cooperation between industrial partners, basic scientists and clinicians on the campus of the University Hospital of Bern (Inselspital) with the ultimate goal to bring novel diagnostic and therapeutic products towards clinical application. 3) The sitem-insel Promoting Services aim to optimize the administrative-regulatory effort along the route from laboratory bench to commercial products.

scholarly journals The Seventh Annual Bio-Ontologies Meeting Moat House Hotel, Glasgow, 30 July 2004

2004 ◽  
Vol 5 (6-7) ◽  
pp. 498-500
Author(s):  
Phillip Lord ◽  
Robert Stevens
Keyword(s):  
Gene Ontology ◽  
Functional Genomics ◽  
Computer Science ◽  
Interest Group ◽  
Special Interest ◽  
Cutting Edge ◽  
Biological Applications ◽  
Fit For Purpose ◽  
First Time ◽  
Selection Of

The Annual Bio-Ontologies Meeting [1] has now reached its seventh consecutive year, running as a special interest group (SIG) of the much larger ISMB conference. This year's meeting in Glasgow had approximately 100 attendees. Since the advent of the Gene Ontology, which coincided with the first Bio-Ontologies Meeting, we have seen a year-on-year strengthening of the field; bio-ontologies has moved from being dominated by computer science to be led by biological applications; discussion is less about ‘what is an ontology?’ and more about ‘how to build an ontology which is fit for purpose?’. This strengthening of the field can be seen elsewhere. Both the main ISMB conference and this year's Pacific Symposium on Biocomputing (PSB) [2] have seen a large number of submissions to their ontologies track. For the first time a selection of the papers from the SIG is being published in this issue ofComparative and Functional Genomics. We hope that this will complement the publications of the larger conferences, bringing to a wider audience the cutting edge research that characterizes the Bio-Ontologies SIG.

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