Injectable poly(γ-glutamic acid)-based biodegradable hydrogels with tunable gelation rate and mechanical strength

2021 ◽  
Author(s):  
Meng Wei ◽  
Yu-I Hsu ◽  
Taka-Aki Asoh ◽  
Moon-Hee Sung ◽  
Hiroshi Uyama
Keyword(s):  
Regenerative Medicine ◽  
Mechanical Strength ◽  
Glutamic Acid ◽  
Clinical Applications ◽  
Injection Time ◽  
Polymer Therapeutics ◽  
Biodegradable Hydrogels ◽  
Rapid Injection ◽  
Potential Applications ◽  
Gelation Rate

Polypeptide-based hydrogels have potential applications in polymer therapeutics and regenerative medicine. However, designing reliable polypeptide-based hydrogels with a rapid injection time and controllable stiffness for clinical applications remains a challenge....

scholarly journals Stem Cells and Regenerative Medicine: Myth or Reality of the 21th Century

2015 ◽  
Vol 2015 ◽  
pp. 1-19 ◽  
Author(s):  
J.-F. Stoltz ◽  
N. de Isla ◽  
Y. P. Li ◽  
D. Bensoussan ◽  
L. Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Regenerative Medicine ◽  
Embryonic Stem ◽  
Clinical Applications ◽  
Cardiac Insufficiency ◽  
Immunomodulatory Activity ◽  
Hematopoietic Stem ◽  
Fetal Stem Cells ◽  
Organ Regeneration

Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin, there has been an increasing interest in the study of undifferentiated progenitors that have the ability to proliferate and differentiate into various tissues. Stem cells (SC) with different potency can be isolated and characterised. Despite the promise of embryonic stem cells, in many cases, adult or even fetal stem cells provide a more interesting approach for clinical applications. It is undeniable that mesenchymal stem cells (MSC) from bone marrow, adipose tissue, or Wharton’s Jelly are of potential interest for clinical applications in regenerative medicine because they are easily available without ethical problems for their uses. During the last 10 years, these multipotent cells have generated considerable interest and have particularly been shown to escape to allogeneic immune response and be capable of immunomodulatory activity. These properties may be of a great interest for regenerative medicine. Different clinical applications are under study (cardiac insufficiency, atherosclerosis, stroke, bone and cartilage deterioration, diabetes, urology, liver, ophthalmology, and organ’s reconstruction). This review focuses mainly on tissue and organ regeneration using SC and in particular MSC.

Biodegradable porous beads and their potential applications in regenerative medicine

2012 ◽  
Vol 22 (23) ◽  
pp. 11442 ◽  
Author(s):  
Sung-Wook Choi ◽  
Yu Zhang ◽  
Yi-Chun Yeh ◽  
A. Lake Wooten ◽  
Younan Xia
Keyword(s):  
Regenerative Medicine ◽  
Potential Applications ◽  
Porous Beads

scholarly journals Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

2021 ◽  
Vol 2021 ◽  
pp. 1-20 ◽  
Author(s):  
Dhinakaran Veeman ◽  
M. Swapna Sai ◽  
P. Sureshkumar ◽  
T. Jagadeesha ◽  
L. Natrayan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Wide Range ◽  
Potential Applications ◽  
Pharmaceutical Industries

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

Regenerative medicine: clinical applications of stem cells

Stem Cells ◽  
2021 ◽  
pp. 159-220
Author(s):  
Christine L. Mummery ◽  
Anja van de Stolpe ◽  
Bernard Roelen ◽  
Hans Clevers
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Clinical Applications

The Potential Applications of Hyaluronic Acid Hydrogels in Biomedicine

Drug Research ◽  
2019 ◽  
Vol 70 (01) ◽  
pp. 6-11 ◽  
Author(s):  
Elham Ahmadian ◽  
Solmaz Maleki Dizaj ◽  
Aziz Eftekhari ◽  
Elaheh Dalir ◽  
Parviz Vahedi ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Wound Repair ◽  
Stem Cell Differentiation ◽  
Clinical Applications ◽  
Cellular Behavior ◽  
Hydrogel Formation ◽  
Potential Applications ◽  
Basic Concepts ◽  
Elastic Sheets

AbstractHyaluronic acid (HA) is widely used in the biomedicine due to its biocompatibility, biodegradability, and nontoxic properties. It is crucial for cell signaling role during morphogenesis, inflammation, and wound repair. After hydrogel formation, HA easily is converted to elastic sheets in order to use in preclinical and clinical applications. In addition, HA-derived hydrogels are easily used as vectors for cell and medication in tissue repairing and regenerative medicine. Moreover, in comparison with other polymers, HA -based hydrogels play a key role in in cellular behavior, including stem cell differentiation. The current paper reviews both basic concepts and recent advances in the development of HA-based hydrogels for biomedical applications.

scholarly journals Autologous Materials in Regenerative Dentistry: Harvested Bone, Platelet Concentrates and Dentin Derivates

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5330
Author(s):  
Sara Bernardi ◽  
Guido Macchiarelli ◽  
Serena Bianchi
Keyword(s):  
Regenerative Medicine ◽  
Bone Tissue ◽  
Clinical Applications ◽  
Physiological Characteristics ◽  
Sinus Lift ◽  
Platelet Concentrates ◽  
Specific Group ◽  
Ridge Augmentation ◽  
Regenerative Dentistry

The jawbone is a peculiar type of bone tissue, unique for its histological, anatomical and physiological characteristics. Therefore, a defect in the maxilla or in the mandible, because of pathological sequelae is difficult to prevent and to restore. Several biomaterials have been and are currently being developed to respond to the demands of regenerative medicine. A specific group of biomaterials used in regenerative dentistry is represented by the autologous materials. Platelet concentrates harvested bone and dentin derivates are indeed used in an attempt to minimise the alveolar resorption or in vertical ridge augmentation procedures or in sinus lift interventions. The aim of this review is to examine the properties of the above-listed materials, to compare them and to indicate eventual clinical applications.

Biosynthesis of Polyglutamic Acid and its Application on Agriculture

2011 ◽  
Vol 183-185 ◽  
pp. 1219-1223 ◽  
Author(s):  
Xiang Yu ◽  
Min Wang ◽  
Qun Hui Wang ◽  
Xu Ming Wang
Keyword(s):  
Water Treatment ◽  
Glutamic Acid ◽  
Biodegradable Polymer ◽  
Water Soluble ◽  
Future Trends ◽  
Polyglutamic Acid ◽  
Separation And Purification ◽  
Potential Applications ◽  
Purification Methods ◽  
Fermentation Parameters

Poly γ-glutamic acid (γ-PGA) is a kind of water soluble and biodegradable polymer, which is nontoxic toward humans and the environment. Therefore, the potential applications of γ-PGA and its derivatives have been of interest in a broad range such as food, cosmetics, medicine, water treatment and agriculture. This paper summarizes γ-PGA synthesis pathways in microorganisms, producing strains, fermentation parameters, as well as separation and purification methods. In addition, the prospect of γ-PGA application on agriculture was introduced, pointing out the problems and the future trends in research and application of γ-PGA.

Regenerative Medicine: Clinical Applications of Stem Cells

Stem Cells ◽  
2011 ◽  
pp. 133-195
Author(s):  
Christine Mummery ◽  
Sir Ian Wilmut ◽  
Anja van de Stolpe ◽  
Bernard A.J. Roelen
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Clinical Applications

scholarly journals Design and Preparation of Polysulfide Flexible Polymers Based on Cottonseed Oil and Its Derivatives

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1858
Author(s):  
Yurong Chen ◽  
Yanxia Liu ◽  
Yidan Chen ◽  
Yagang Zhang ◽  
Xingjie Zan
Keyword(s):  
Tensile Strength ◽  
Free Radical ◽  
Mechanical Strength ◽  
Cottonseed Oil ◽  
Radical Addition ◽  
Flexible Polymers ◽  
Strength Based ◽  
Potential Applications ◽  
Free Radical Addition ◽  
Polysulfide Polymers

Polysulfide-derived polymers with a controllable density and mechanical strength were designed and prepared successfully using bio-based cottonseed oil (CO) and its derivatives, including fatty acid of cottonseed oil (COF) and sodium soap of cottonseed oil (COS). The reaction features of CO, COF and COS for polysulfide polymers were investigated and compared. Based on the free radical addition mechanism, COF reacts with sulfur to generate serials of polysulfide-derived polymers. COF strongly influences the density and tensile strength of these polymer composites. Whereas COS was not involved in the reaction with sulfur, as a filler, it could increase the density and tensile strength of polysulfide-derived polymers. Moreover, the results showed that these samples had an excellent reprocessability and recyclability. These polysulfide-based polymers, with an adjustable density and mechanical strength based on CO and derivatives, could have potential applications as bio-based functional supplementary additives.

Sign in / Sign up

Export Citation Format

Share Document