Molecular Design of Peptide Amphiphiles for Controlled Self-Assembly and Drug Release

2021 ◽  
Author(s):  
Ziqi Liu ◽  
Xuan Tang ◽  
Feng Feng ◽  
Jing Xu ◽  
Can Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Self Assembly ◽  
Molecular Design ◽  
Drug Dose ◽  
Peptide Amphiphiles ◽  
Great Promise ◽  
Specific Drug ◽  
Peptide Amphiphile ◽  
Drug Delivery Applications

Peptide amphiphile-based supramolecular hydrogels hold great promise in drug delivery applications. To cater for specific drug dose in a demanding biomedical scenario, sophisticated design of peptide amphiphile (PA) molecule is...

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

scholarly journals Self-assembly of the monohydroxy triterpenoid lupeol yielding nano-fibers, sheets and gel: environmental and drug delivery applications

RSC Advances ◽  
2021 ◽  
Vol 11 (53) ◽  
pp. 33500-33510
Author(s):  
Saikat Kumar Panja ◽  
Soumen Patra ◽  
Braja Gopal Bag
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Organic Liquids ◽  
Supramolecular Gels ◽  
Drug Delivery Applications

The monohydroxy triterpenoid lupeol forms gels in organic and aqueous organic liquids via self-assembly. The resulting supramolecular gels could be utilized for pollutant capture, drug entrapment and release applications.

scholarly journals A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases

2018 ◽  
Vol 15 (144) ◽  
pp. 20180236 ◽  
Author(s):  
Alessandra Marrella ◽  
Michele Iafisco ◽  
Alessio Adamiano ◽  
Stefano Rossi ◽  
Maurizio Aiello ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Animal Model ◽  
Cardiovascular Diseases ◽  
Drug Release ◽  
Biological Effects ◽  
Low Frequency ◽  
Controlled Drug Release ◽  
Drug Dose

Alternative drug delivery approaches to treat cardiovascular diseases are currently under intense investigation. In this domain, the possibility to target the heart and tailor the amount of drug dose by using a combination of magnetic nanoparticles (NPs) and electromagnetic devices is a fascinating approach. Here, an electromagnetic device based on Helmholtz coils was generated for the application of low-frequency magnetic stimulations to manage drug release from biocompatible superparamagnetic Fe-hydroxyapatite NPs (FeHAs). Integrated with a fluidic circuit mimicking the flow of the cardiovascular environment, the device was efficient to trigger the release of a model drug (ibuprofen) from FeHAs as a function of the applied frequencies. Furthermore, the biological effects on the cardiac system of the identified electromagnetic exposure were assessed in vitro and in vivo by acute stimulation of isolated adult cardiomyocytes and in an animal model. The cardio-compatibility of FeHAs was also assessed in vitro and in an animal model. No alterations of cardiac electrophysiological properties were observed in both cases, providing the evidence that the combination of low-frequency magnetic stimulations and FeHAs might represent a promising strategy for controlled drug delivery to the failing heart.

Glutathione-adaptive peptide amphiphile vesicles rationally designed using positionable disulfide-bridges for effective drug transport

2020 ◽  
Vol 11 (28) ◽  
pp. 4547-4556
Author(s):  
Hayeon Kim ◽  
Inhye Kim ◽  
Jun Ho Hwang ◽  
Jaehyun Park ◽  
Hyungju Ahn ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cells ◽  
Drug Transport ◽  
Drug Loading ◽  
Effective Drug ◽  
Peptide Amphiphiles ◽  
Disulfide Bridges ◽  
Peptide Amphiphile ◽  
Disulfide Linkages ◽  
Self Assembled

The drug loading/releasing capability of GSH-responsive nanovesicles self-assembled from peptide amphiphiles was controlled by varying the location and number of disulfide-linkages in the peptide for the selective drug-release into tumor cells.

scholarly journals Synthesis of non-ionic bolaamphiphiles and study of their self-assembly and transport behaviour for drug delivery applications

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31777-31782 ◽  
Author(s):  
Rashmi Rashmi ◽  
Abhishek K. Singh ◽  
Katharina Achazi ◽  
Boris Schade ◽  
Christoph Böttcher ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Transport Behaviour ◽  
Drug Delivery Applications

Non-ionic bolaamphiphiles as nanocarrier for biomedical applications.

Small-Molecule Probe for Sensing Serum Albumin with Consequential Self-Assembly as a Fluorescent Organic Nanoparticle for Bioimaging and Drug-Delivery Applications

2020 ◽  
Vol 3 (5) ◽  
pp. 3099-3113 ◽  
Author(s):  
Subhajit Guria ◽  
Avijit Ghosh ◽  
Priyanka Upadhyay ◽  
Manas kumar Das ◽  
Tanushree Mishra ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Serum Albumin ◽  
Small Molecule ◽  
Self Assembly ◽  
Drug Delivery Applications ◽  
Small Molecule Probe
Sign in / Sign up

Export Citation Format

Share Document