Glutathione-adaptive peptide amphiphile vesicles rationally designed using positionable disulfide-bridges for effective drug transport

2020 ◽  
Vol 11 (28) ◽  
pp. 4547-4556
Author(s):  
Hayeon Kim ◽  
Inhye Kim ◽  
Jun Ho Hwang ◽  
Jaehyun Park ◽  
Hyungju Ahn ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cells ◽  
Drug Transport ◽  
Drug Loading ◽  
Effective Drug ◽  
Peptide Amphiphiles ◽  
Disulfide Bridges ◽  
Peptide Amphiphile ◽  
Disulfide Linkages ◽  
Self Assembled

The drug loading/releasing capability of GSH-responsive nanovesicles self-assembled from peptide amphiphiles was controlled by varying the location and number of disulfide-linkages in the peptide for the selective drug-release into tumor cells.

Intracellular thiol-responsive nanosized drug carriers self-assembled by poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly(ethylene glycol) having multiple bioreducible disulfide linkages in hydrophobic blocks

RSC Advances ◽  
2016 ◽  
Vol 6 (19) ◽  
pp. 15558-15576 ◽  
Author(s):  
Seung Yeon Moon ◽  
Yeon Su Choi ◽  
Jung-Kyo Cho ◽  
Minjong Yu ◽  
Eunji Lee ◽  
...  
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Polymeric Nanoparticles ◽  
Drug Carriers ◽  
Effective Drug ◽  
Poly Ethylene Glycol ◽  
Hydrophobic Domain ◽  
Disulfide Linkages ◽  
Self Assembled ◽  
Poly Ethylene

Intracellular thiol can trigger effective drug release from polymeric nanoparticles having multiple disulfide linkages in the hydrophobic domain.

Redox-sensitive hyaluronic acid–paclitaxel conjugate micelles with high physical drug loading for efficient tumor therapy

2015 ◽  
Vol 6 (46) ◽  
pp. 8047-8059 ◽  
Author(s):  
Tingjie Yin ◽  
Jing Wang ◽  
Lifang Yin ◽  
Linjia Shen ◽  
Jianping Zhou ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Drug Release ◽  
Cellular Uptake ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Drug Conjugates ◽  
Self Assembled ◽  
Polymer Drug Conjugates

Characterization of targeted redox-sensitive micelles self-assembled from polymer–drug conjugates exhibiting conspicuous drug loading capabilities, selective cellular uptake, rapid intracellular disassembly and drug release is presented.

Molecular Design of Peptide Amphiphiles for Controlled Self-Assembly and Drug Release

2021 ◽  
Author(s):  
Ziqi Liu ◽  
Xuan Tang ◽  
Feng Feng ◽  
Jing Xu ◽  
Can Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Self Assembly ◽  
Molecular Design ◽  
Drug Dose ◽  
Peptide Amphiphiles ◽  
Great Promise ◽  
Specific Drug ◽  
Peptide Amphiphile ◽  
Drug Delivery Applications

Peptide amphiphile-based supramolecular hydrogels hold great promise in drug delivery applications. To cater for specific drug dose in a demanding biomedical scenario, sophisticated design of peptide amphiphile (PA) molecule is...

scholarly journals Schiff-Linked PEGylated Doxorubicin Prodrug Forming pH-Responsive Nanoparticles With High Drug Loading and Effective Anticancer Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Jian Song ◽  
Bingbing Xu ◽  
Hui Yao ◽  
Xiaofang Lu ◽  
Yang Tan ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cells ◽  
Drug Loading ◽  
Drug Carriers ◽  
Anticancer Therapy ◽  
Therapeutic Effects ◽  
Ph Responsive ◽  
High Drug ◽  
High Drug Loading ◽  
Mcf 7

Developing efficacious drug delivery systems for targeted cancer chemotherapy remains a major challenge. Here we demonstrated a kind of pH-responsive PEGylated doxorubicin (DOX) prodrug via the effective esterification and Schiff base reactions, which could self-assemble into the biodegradable micelles in aqueous solutions. Owing to low pH values inside the tumor cells, these PEG-Schiff-DOX nanoparticles exhibited high drug loading ability and pH-responsive drug release behavior within the tumor cells or tissues upon changes in physical and chemical environments, but they displayed good stability at physiological conditions for a long period. CCK-8 assay showed that these PEGylated DOX prodrugs had a similar cytotoxicity to the MCF-7 tumor cells as the free DOX drug. Moreover, this kind of nanoparticle could also encapsulate small DOX drugs with high drug loading, sufficient drug release and enhanced therapeutic effects toward MCF-7 cells, which will be benefited for developing more drug carriers with desirable functions for clinical anticancer therapy.

Supramolecular peptide amphiphile based nanocarrier for pH-triggered Dox release, overcoming drug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (90) ◽  
pp. 86943-86946 ◽  
Author(s):  
Sheng Lu ◽  
Yong Ding ◽  
Weijia Cui ◽  
Ran Pan ◽  
Wen Xu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Drug Release ◽  
Cancer Cells ◽  
Peptide Amphiphile ◽  
Triggered Drug Release ◽  
Self Assembled

Self-assembled peptide amphiphile–doxorubicin conjugates showed pH-triggered drug release and ability to combat the drug resistance in cancer cells.

Study on the Preparation of Chitosan/PVA Sustained - Release Microspheres

2011 ◽  
Vol 217-218 ◽  
pp. 71-74
Author(s):  
Jian Xiang Yu ◽  
Qi Song Shi
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Sustained Release ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Crosslinking Agent ◽  
Delivery Systems ◽  
Effective Drug ◽  
Cross Linking ◽  
Mass Ratio

Chitosan has prompted the continuous impetus for the development of safe and effective drug delivery systems because of its unique physicochemical and biological characteristics. In this study, PEG-chitosan microspheres loaded with levofloxacin for carrying drugs were prepared by the emulsion cross-linking method. The effect of drug process, the emulsifier, the amount of crosslinking agent, stirring speed, temperature, crosslinking time on the prepare experiment were studied. The effect of the quantity of chitosan and PEG, the mass ratio of chitosan and levofloxacin on the drug loading and release ability were studied in drug release experiments too.

Solid Lipid Nanoparticles for Topical Delivery of Acitretin for the Treatment of Psoriasis by Design of Experiment

2020 ◽  
Vol 12 (2) ◽  
pp. 4474-4491
Author(s):  
Rajkumar Aland ◽  
Ganesan M ◽  
P. Rajeswara Rao ◽  
Bhikshapathi D. V. R. N.
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Solid Lipid Nanoparticles ◽  
Drug Loading ◽  
Entrapment Efficiency ◽  
Lipid Nanoparticles ◽  
Tem Analysis ◽  
In Vitro Drug Release ◽  
Solid Lipid

The main objective for this investigation is to develop and optimize the solid lipid nanoparticles formulation of acitretin for the effective drug delivery. Acitretin loaded SLNs were prepared by hot homogenization followed by the ultrasonication using Taguchi’s orthogonal array with eight parameters that could affect the particle size and entrapment efficiency. Based on the results from the analyses of the responses obtained from Taguchi design, three different independent variables including surfactant concentration (%), lipid to drug ratio (w/w) and sonication time (s) were selected for further investigation using central composite design. The  lipid Dynasan-116, surfactant poloxomer-188 and co surfactant egg lecithin resulted in better percent drug loading and evaluated for particle size, zeta potential, drug entrapment efficiency, in vitro drug release and stability. All parameters were found to be in an acceptable range. TEM analysis has demonstrated the presence of individual nanoparticles in spherical shape and the results were compatible with particle size measurements.  In vitro drug release of optimized SLN formulation (F2) was found to be 95.63 ± 1.52%, whereas pure drug release was 30.12 after 60 min and the major mechanism of drug release follows first order kinetics release data for optimized formulation (F2) with non-Fickian (anomalous) with a strong correlation coefficient (R2 = 0.94572) of Korsemeyer-Peppas model. The total drug content of acitretin gel formulation was found to 99.86 ± 0.012% and the diameter of gel formulation was 6.9 ± 0.021 cm and that of marketed gel was found to be 5.7 ± 0.06 cm, indicating better spreadability of SLN based gel formulation. The viscosity of gel formulation at 5 rpm was found to be 6.1 x 103 ± 0.4 x 103 cp. The release rate (flux) of acitretin across the membrane and excised skin differs significantly, which indicates about the barrier properties of skin. The flux value for SLN based gel formulation (182.754 ± 3.126 μg cm−2 h−1) was found to be higher than that for marketed gel (122.345 ± 4.786 μg cm−2 h−1). The higher flux and Kp values of SLN based gel suggest that it might be able to enter the skin easily as compared with marketed gel with an advantage of low interfacial tension of the emulsifier film that ensures an excellent contact to the skin. This topically oriented SLN based gel formulation could be useful in providing site-specific dermal treatment of psoriasis

Sign in / Sign up

Export Citation Format

Share Document