Correction: A continuum membrane model can predict curvature sensing by helix insertion

A continuum membrane model can predict curvature sensing by helix insertion

Soft Matter ◽

10.1039/d1sm01333e ◽

2021 ◽

Author(s):

Yiben Fu ◽

Wade F Zeno ◽

Jeanne Stachowiak ◽

Margaret E. Johnson

Keyword(s):

Protein Domains ◽

Membrane Model ◽

Physical Parameters ◽

Curvature Sensing ◽

Amphipathic Helices ◽

Preferential Binding ◽

Curved Membranes

Protein domains, such as ENTH (Epsin N-terminal homology) and BAR (bin/amphiphysin/rvs), contain amphipathic helices that drive preferential binding to curved membranes. However, predicting how the physical parameters of these domains...

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Allosteric regulation of GPCR Rhodopsin by soft matter

10.1021/scimeetings.0c06874 ◽

2020 ◽

Author(s):

Nipuna Weerasinghe ◽

Steven Fried ◽

Anna Eitel ◽

Andrey Struts ◽

Suchithranga Perera ◽

...

Keyword(s):

Soft Matter ◽

Allosteric Regulation

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Van der Waals, Casimir, and Lifshitz forces in soft matter

Uspekhi Fizicheskih Nauk ◽

10.3367/ufnr.0185.201509g.0964 ◽

2015 ◽

Vol 185 (9) ◽

pp. 964-969 ◽

Cited By ~ 2

Author(s):

E.I. Kats

Keyword(s):

Soft Matter ◽

Van Der Waals

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Influence of Rim Run-Out on the Nonuniformity of Tire-Wheel Assemblies

Tire Science and Technology ◽

10.2346/1.2139538 ◽

1994 ◽

Vol 22 (2) ◽

pp. 99-120 ◽

Cited By ~ 1

Author(s):

T. B. Rhyne ◽

R. Gall ◽

L. Y. Chang

Keyword(s):

Finite Element ◽

Radial Force ◽

Membrane Model ◽

Model Experiments ◽

Force Variation ◽

One To One ◽

The One

Abstract An analytical membrane model is used to study how wheel imperfections are converted into radial force variation of the tire-wheel assembly. This model indicates that the radial run-out of the rim generates run-out of the tire-wheel assembly at slightly less than the one to one ratio that was expected. Lateral run-out of the rim is found to generate radial run-out of the tire-wheel assembly at a ratio that is dependent on the tire design and the wheel width. Finite element studies of a production tire validate and quantify the results of the membrane model. Experiments using a specially constructed precision wheel demonstrate the behavior predicted by the models. Finally, a population of production tires and wheels show that the lateral run-out of the rims contribute a significant portion to the assembly radial force variation. These findings might be used to improve match-mounting results by taking lateral rim run-out into account.

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Natural Killer Cell Inspired AIE Nanoterminator for Blood-Brain-Barrier Crossing via Tight-Junction Modulation and NIR-II Gliomas Theranostics

10.26434/chemrxiv.12504404.v1 ◽

2020 ◽

Author(s):

Guanjun Deng ◽

Xinghua Peng ◽

Zhihong Sun ◽

Wei Zheng ◽

Jia Yu ◽

...

Keyword(s):

Natural Killer Cell ◽

Natural Killer ◽

Intracellular Signaling ◽

Soft Matter ◽

Tumor Imaging ◽

Nk Cell ◽

Killer Cell ◽

Light Illumination ◽

Blood Brain ◽

Intracellular Signaling Cascade

Nature has always inspired robotic designs and concepts. It is conceivable that biomimic nanorobots will soon play a prominent role in medicine. In this paper, we developed a natural killer cell-mimic AIE nanoterminator (NK@AIEdots) by coating natural kill cell membrane on the AIE-active polymeric endoskeleton, PBPTV, a highly bright NIR-II AIE-active conjugated polymer. Owning to the AIE and soft-matter characteristics of PBPTV, as-prepared nanoterminator maintained the superior NIR-II brightness (quantum yield ~8%) and good biocompatibility. Besides, they could serve as tight junctions (TJs) modulator to trigger an intracellular signaling cascade, causing TJs disruption and actin cytoskeleton reorganization to form intercellular “green channel” to help themselves crossing Blood-Brain Barriers (BBB) silently. Furthermore, they could initiatively accumulate to glioblastoma cells in the complex brain matrix for high-contrast and through-skull tumor imaging. The tumor growth was also greatly inhibited by these nanoterminator under the NIR light illumination. As far as we known, The QY of PBPTV is the highest among the existing NIR-II luminescent conjugated polymers. Besides, the NK-cell biomimetic nanorobots will open new avenue for BBB-crossing delivery.

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Sensitive Mechanocontrolled Luminescence in Cross-Linked Polymer Films

10.26434/chemrxiv.9943943.v1 ◽

2019 ◽

Author(s):

Ayumu Karimata ◽

Pradnya Patil ◽

Eugene Khaskin ◽

Sébastien Lapointe ◽

robert fayzullin ◽

...

Keyword(s):

Mechanical Stress ◽

Polymer Films ◽

Soft Matter ◽

Small Strain ◽

Visual Methods ◽

Photoluminescence Intensity ◽

Stimuli Responsive ◽

Responsive Materials ◽

Highly Sensitive ◽

Mechanical Stretching

Direct translation of mechanical force into changes in chemical behavior on a molecular level has important implication not only for the fundamental understanding of mechanochemical processes, but also for the development of new stimuli-responsive materials. In particular, detection of mechanical stress in polymers via non-destructive methods is important in order to prevent material failure and to study the mechanical properties of soft matter. Herein, we report that highly sensitive changes in photoluminescence intensity can be observed in response to the mechanical stretching of cross-linked polymer films when using stable, (pyridinophane)Cu-based dynamic mechanophores. Upon stretching, the luminescence intensity increases in a fast and reversible manner even at small strain (< 50%) and applied stress (< 0.1 MPa) values. Such sensitivity is unprecedented when compared to previously reported systems based on organic mechanophores. The system also allows for the detection of weak mechanical stress by spectroscopic measurements or by direct visual methods.<br>

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