Asymmetric desorption of lipid oxidation products induces membrane bending

Soft Matter ◽  
2021 ◽  
Author(s):  
Rui Jin ◽  
Tobias Baumgart
Keyword(s):  
Oxidative Stress ◽  
Lipid Oxidation ◽  
Cellular Membrane ◽  
Oxidation Products ◽  
Metabolic Processes ◽  
Lipid Oxidation Products ◽  
Membrane Bending

Lipid oxidation, detected in metabolic processes, is induced in excess when the cellular membrane suffers extra oxidative stress. Lipid oxidation can compromise biomembrane function in part through perturbations of lipid...

Differential PDGF secretion by graft and aortic SMC in response to oxidized LDL

2002 ◽  
Vol 283 (2) ◽  
pp. H725-H732 ◽  
Author(s):  
Afaf Absood ◽  
Akira Furutani ◽  
Tsutomu Kawamura ◽  
Linda M. Graham
Keyword(s):  
Oxidative Stress ◽  
Lipid Oxidation ◽  
Oxidized Ldl ◽  
Low Density Lipoprotein ◽  
Vascular Grafts ◽  
Density Lipoprotein ◽  
Oxidation Products ◽  
Enzyme Linked Immunosorbent Assay ◽  
Oxidized Low Density Lipoprotein ◽  
Lipid Oxidation Products

Smooth muscle cells (SMC) from prosthetic vascular grafts constitutively secrete higher levels of platelet-derived growth factor-AA (PDGF-AA) than aortic SMC. Lipid oxidation products accumulate in grafts and may stimulate PDGF production. The effect of oxidized low-density lipoprotein (oxLDL) on PDGF-AA secretion by aortic and graft SMC was compared. SMC isolated from canine thoracic aorta or Dacron thoracoabdominal grafts ( n = 10) were incubated with native LDL or oxLDL (0–400 μg/ml) for 72 h. PDGF-AA in the conditioned medium was measured with enzyme-linked immunosorbent assay. OxLDL increased PDGF-AA production by graft SMC from 78 ± 2 to 256 ± 16 pg PDGF/μg DNA and aortic SMC from 21 ± 1 to 40 ± 2 pg PDGF/μg DNA. Native LDL had no effect. N-acetylcysteine inhibited oxLDL-induced PDGF increase. Both superoxide and H2O2 stimulated PDGF secretion by graft SMC had little effect on aortic SMC. Our results suggest that PDGF production by graft (synthetic) SMC is more sensitive to stimulation by oxidative stress than aortic (contractile) SMC. Lipid oxidation products that accumulate in prosthetic vascular grafts can cause an oxidative stress, which stimulates PDGF production by graft SMC. PDGF can induce migration of aortic SMC onto the graft, contributing to the development of intimal hyperplasia.

scholarly journals Analysis of Oxidative Stress-Related Markers in Crohn’s Disease Patients at Surgery and Correlations with Clinical Findings

Antioxidants ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 378 ◽  
Author(s):  
Cristina Luceri ◽  
Elisabetta Bigagli ◽  
Sara Agostiniani ◽  
Francesco Giudici ◽  
Daniela Zambonin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Oxidation ◽  
Disease Activity ◽  
Severe Disease ◽  
Oxidation Products ◽  
Therapeutic Monitoring ◽  
Thiobarbituric Acid Reactive Substance ◽  
Reducing Ability ◽  
Lipid Oxidation Products ◽  
End Products

Crohn’ disease (CD) patients are at high risk of postoperative recurrence and new tools for the assessment of disease activity are needed to prevent long-term complications. In these patients, the over-production of ROS generated by inflamed bowel tissue and inflammatory cells activates a pathogenic cascade that further exacerbates inflammation and leads to increased oxidative damage to DNA, proteins, and lipids. We measured the products of protein/lipid oxidation and the total antioxidant capacity (ferric reducing ability of plasma, FRAP) in the serum of CD patients with severe disease activity requiring surgery with the aim to characterize their redox status and identify associations between oxidative stress-related markers and their clinical characteristics. At the systemic level, CD was associated with increased levels of protein and lipid oxidation products when compared to healthy volunteers, even though the FRAP values were similar. Advanced oxidation protein product (AOPP) levels showed the highest difference between patients and the controls (11.25, 5.02–15.15, vs. 1.36, 0.75–2.70, median, interquartile range; p < 0.0001) and the analysis of receiver operating characteristic (ROC) curves, indicated for AOPP, the best area under the curve (AUC) value for CD prediction. Advanced glycated end-products (AGEs) were also significantly higher in CD patients (p < 0.01), which is of interest since AOPP and AGEs are both able to activate the membrane receptor for advanced glycation end products (RAGE) involved in inflammatory diseases. Thiobarbituric acid reactive substance (TBARS) levels were significantly higher in CD patients with ileal localization and aggressive disease behavior, in smokers, and in patients suffering from allergies. In conclusion, our data indicate that circulating oxidative stress biomarkers may be attractive candidates as disease predictors as well as for clinical or therapeutic monitoring of CD. Our results also suggest that AOPP/AGEs and RAGE signaling may represent a pathogenic factor and a potential therapeutic target in CD.

scholarly journals Accumulation of Aluminium and Physiological Status of Tree Foliage in the Vicinity of a Large Aluminium Smelter

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
E. D. Wannaz ◽  
J. H. Rodriguez ◽  
T. Wolfsberger ◽  
H. A. Carreras ◽  
M. L. Pignata ◽  
...  
Keyword(s):  
Lipid Oxidation ◽  
Membrane Lipid ◽  
Physiological Parameters ◽  
Oxidation Products ◽  
Physiological Status ◽  
Pollution Gradient ◽  
Sulphur Deposition ◽  
Aluminium Production ◽  
Lipid Oxidation Products ◽  
Tree Foliage

A pollution gradient was observed in tree foliage sampled in the vicinity of a large aluminium production facility in Patagonia (Argentina). Leaves ofEucalyptus rostrata, and Populus hybridusand different needle ages ofPinusspec. were collected and concentrations of aluminium (Al) and sulphur (S) as well as physiological parameters (chlorophyll and lipid oxidation products) were analyzed. Al and S concentrations indicate a steep pollution gradient in the study showing a relationship with the physiological parameters in particular membrane lipid oxidation products. The present study confirms that aluminium smelting results in high Al and sulphur deposition in the study area, and therefore further studies should be carried out taking into account potentially adverse effects of these compounds on human and ecosystem health.

Volatile Lipid Oxidation Products of Wagyu and Domestic Breeds of Beef

1996 ◽  
Vol 44 (4) ◽  
pp. 1091-1095 ◽  
Author(s):  
Terri D. Boylston ◽  
Sarah A. Morgan ◽  
Kristen A. Johnson ◽  
Ray W. Wright, ◽  
Jan R. Busboom ◽  
...  
Keyword(s):  
Lipid Oxidation ◽  
Oxidation Products ◽  
Lipid Oxidation Products
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