Role of complementary shape in protein dimerization

Soft Matter ◽  
2021 ◽  
Author(s):  
Fengyi Gao ◽  
Jens Glaser ◽  
Sharon C Glotzer
Keyword(s):  
Colloidal Nanoparticles ◽  
Protein Dimerization ◽  
Form Complex ◽  
Biomolecular Complexes

Shape guides colloidal nanoparticles to form complex assemblies, but its role in defining interfaces in biomolecular complexes is less clear. In this work, we isolate the role of shape in...

scholarly journals Interplay Between SOX9, Wnt/β-Catenin and Androgen Receptor Signaling in Castration-Resistant Prostate Cancer

2019 ◽  
Vol 20 (9) ◽  
pp. 2066 ◽  
Author(s):  
Namrata Khurana ◽  
Suresh C. Sikka
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Signaling Pathways ◽  
Critical Role ◽  
Castration Resistant Prostate Cancer ◽  
Form Complex ◽  
Androgen Receptor Signaling ◽  
Castration Resistant ◽  
Signaling Axis

Androgen receptor (AR) signaling plays a key role not only in the initiation of prostate cancer (PCa) but also in its transition to aggressive and invasive castration-resistant prostate cancer (CRPC). However, the crosstalk of AR with other signaling pathways contributes significantly to the emergence and growth of CRPC. Wnt/β-catenin signaling facilitates ductal morphogenesis in fetal prostate and its anomalous expression has been linked with PCa. β-catenin has also been reported to form complex with AR and thus augment AR signaling in PCa. The transcription factor SOX9 has been shown to be the driving force of aggressive and invasive PCa cells and regulate AR expression in PCa cells. Furthermore, SOX9 has also been shown to propel PCa by the reactivation of Wnt/β-catenin signaling. In this review, we discuss the critical role of SOX9/AR/Wnt/β-catenin signaling axis in the development and progression of CRPC. The phytochemicals like sulforaphane and curcumin that can concurrently target SOX9, AR and Wnt/β-catenin signaling pathways in PCa may thus be beneficial in the chemoprevention of PCa.

scholarly journals What is the role of amyloid precursor protein dimerization?

2010 ◽  
Vol 4 (2) ◽  
pp. 268-272 ◽  
Author(s):  
Naouel Ben Khalifa ◽  
Joanne Van Hees ◽  
Bernadette Tasiaux ◽  
Sandra Huysseune ◽  
Steven O. Smith ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Protein Dimerization

scholarly journals Metabolic modulation regulates cardiac wall morphogenesis in zebrafish

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Ryuichi Fukuda ◽  
Alla Aharonov ◽  
Yu Ting Ong ◽  
Oliver A Stone ◽  
Mohamed El-Brolosy ◽  
...  
Keyword(s):  
Cardiac Development ◽  
Glycolytic Enzyme ◽  
Form Complex ◽  
Neonatal Cardiomyocytes ◽  
Cardiac Wall ◽  
Wall Structures ◽  
Resolution Imaging ◽  
Inhibition Of Glycolysis ◽  
And Behavior

During cardiac development, cardiomyocytes form complex inner wall structures called trabeculae. Despite significant investigation into this process, the potential role of metabolism has not been addressed. Using single cell resolution imaging in zebrafish, we find that cardiomyocytes seeding the trabecular layer actively change their shape while compact layer cardiomyocytes remain static. We show that Erbb2 signaling, which is required for trabeculation, activates glycolysis to support changes in cardiomyocyte shape and behavior. Pharmacological inhibition of glycolysis impairs cardiac trabeculation, and cardiomyocyte-specific loss- and gain-of-function manipulations of glycolysis decrease and increase trabeculation, respectively. In addition, loss of the glycolytic enzyme pyruvate kinase M2 impairs trabeculation. Experiments with rat neonatal cardiomyocytes in culture further support these observations. Our findings reveal new roles for glycolysis in regulating cardiomyocyte behavior during cardiac wall morphogenesis.

scholarly journals New N-(oxazolylmethyl)-thiazolidinedione Active against Candida albicans Biofilm: Potential Als Proteins Inhibitors

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2522 ◽  
Author(s):  
Gabriel Marc ◽  
Cătălin Araniciu ◽  
Smaranda Oniga ◽  
Laurian Vlase ◽  
Adrian Pîrnău ◽  
...  
Keyword(s):  
Biofilm Formation ◽  
Infection Prevention ◽  
Public Health Problem ◽  
Opportunistic Pathogen ◽  
Surface Proteins ◽  
Form Complex ◽  
New Approach ◽  
New Class ◽  
New Compounds

C. albicans is the most frequently occurring fungal pathogen, and is becoming an increasing public health problem, especially in the context of increased microbial resistance. This opportunistic pathogen is characterized by a versatility explained mainly by its ability to form complex biofilm structures that lead to enhanced virulence and antibiotic resistance. In this context, a review of the known C. albicans biofilm formation inhibitors were performed and a new N-(oxazolylmethyl)-thiazolidinedione scaffold was constructed. 16 new compounds were synthesized and characterized in order to confirm their proposed structures. A general antimicrobial screening against Gram-positive and Gram-negative bacteria, as well as fungi, was performed and revealed that the compounds do not have direct antimicrobial activity. The anti-biofilm activity evaluation confirmed the compounds act as selective inhibitors of C. albicans biofilm formation. In an effort to substantiate this biologic profile, we used in silico investigations which suggest that the compounds could act by binding, and thus obstructing the functions of, the C. albicans Als surface proteins, especially Als1, Als3, Als5 and Als6. Considering the well documented role of Als1 and Als3 in biofilm formation, our new class of compounds that target these proteins could represent a new approach in C. albicans infection prevention and management.

Proximity versus allostery: the role of regulated protein dimerization in biology

1994 ◽  
Vol 1 (3) ◽  
pp. 131-136 ◽  
Author(s):  
David J. Austin ◽  
Stuart L. Schreiber ◽  
Gerald R. Crabtree
Keyword(s):  
Protein Dimerization

The key role of protodeauration in the gold-catalyzed reaction of 1,3-diynes with pyrrole and indole to form complex heterocycles

2020 ◽  
Vol 7 (8) ◽  
pp. 997-1005
Author(s):  
Ioannis Stylianakis ◽  
Olalla Nieto Faza ◽  
Carlos Silva López ◽  
Antonios Kolocouris
Keyword(s):  
Form Complex

The mechanism of indole and carbazole formation via a formal [4 + 2] cycloaddition strategy is dominated by the protodeauration step.

Point and Extended Defect Interactions in Silicon

1997 ◽  
Vol 469 ◽  
Author(s):  
M. E. Law ◽  
S. K. Earles
Keyword(s):  
Point Defects ◽  
Quantitative Model ◽  
Extended Defects ◽  
Form Complex ◽  
Extended Defect ◽  
Enhanced Diffusion ◽  
Defect Interactions ◽  
Short Time ◽  
Surface Sink

ABSTRACTTransient Enhanced Diffusion (TED) is one of the biggest modeling challenges present in predicting scaled technologies. Damage from implantation of dopant ions changes the diffusivities of the dopants and precipitates to form complex extended defects. Developing a quantitative model for the defect behavior during short time, low temperature anneals is a key to explaining TED. The surface can play a defining role in the removal of point defects from the bulk, but there is a lot of controversy over the role and strength of the surface sink for point defects. The controversy will be reviewed, and new experimental results will be presented that investigate the role of the surface on TED.

Role of Surface Metal Clusters in SERS Spectra of Ligands Adsorbed on Ag Colloidal Nanoparticles

2008 ◽  
Vol 112 (3) ◽  
pp. 762-767 ◽  
Author(s):  
Maurizio Muniz-Miranda ◽  
Marco Pagliai ◽  
Gianni Cardini ◽  
Vincenzo Schettino
Keyword(s):  
Metal Clusters ◽  
Colloidal Nanoparticles ◽  
Surface Metal

scholarly journals The Osteoprotegerin - Von Willebrand Factor Complex: Protagonist Or Bystander In Atherothrombosis?

2016 ◽  
Vol 62 (2) ◽  
pp. 289-290
Author(s):  
Elod Nagy
Keyword(s):  
Risk Factors ◽  
Endothelial Cells ◽  
Von Willebrand Factor ◽  
Relevant Literature ◽  
Form Complex ◽  
Pathophysiological Role ◽  
Factor Form ◽  
Von Willebrand ◽  
Willebrand Factor

AbstractTwo important cardiovascular risk factors, osteoprotegerin and Von Willebrand Factor form complex in endothelial cells and in circulating blood. The pathophysiological role of the complex is unknown. We give a brief review of the relevant literature and confront it with some of our recent findings regarding the OPG-VWF correlation.

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