3D printed nitric oxide-releasing poly(acrylic acid)/F127/cellulose nanocrystal hydrogels

Soft Matter ◽  
2021 ◽  
Author(s):  
Murilo Izidoro Santos ◽  
Laura C.E. Da Silva ◽  
Mateus Peres Bomediano ◽  
Daniele Mayara Catori ◽  
Maria do Carmo Gonçalves ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Acrylic Acid ◽  
Topical Delivery ◽  
Cellulose Nanocrystal ◽  
3D Printed ◽  
Nitric Oxide Releasing ◽  
Poly Acrylic Acid

Hydrogels have been used as matrices for the topical delivery of nitric oxide (NO) for obtaining vasodilation, wound healing and analgesic actions. More recently, supramolecular hydrogels comprised of poly(acrylic acid)...

scholarly journals Wound healing action of topical nitric oxide releasing poly(acrylic acid)/pluronic F127 hydrogel membranes

2016 ◽  
Author(s):  
LUCAS MILITÃO ◽  
MARCELO GANZAROLLI DE OLIVEIRA ◽  
MATHILDE CHAMPEAU ◽  
CARLOS P. JARA ◽  
ELIANA PEREIRA DE ARAUJO
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Acrylic Acid ◽  
Pluronic F127 ◽  
Hydrogel Membranes ◽  
Nitric Oxide Releasing ◽  
Poly Acrylic Acid

Supramolecular poly(acrylic acid)/F127 hydrogel with hydration-controlled nitric oxide release for enhancing wound healing

2018 ◽  
Vol 74 ◽  
pp. 312-325 ◽  
Author(s):  
Mathilde Champeau ◽  
Valéria Póvoa ◽  
Lucas Militão ◽  
Flávia M. Cabrini ◽  
Guilherme F. Picheth ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Acrylic Acid ◽  
Nitric Oxide Release ◽  
Poly Acrylic Acid

scholarly journals Superabsorbent poly(acrylic acid) and antioxidant poly(ester amide) hybrid hydrogel for enhanced wound healing

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Jianhua Zhang ◽  
Junfei Hu ◽  
Baoshu Chen ◽  
Tianbao Zhao ◽  
Zhipeng Gu
Keyword(s):  
Wound Healing ◽  
Acrylic Acid ◽  
Protein Denaturation ◽  
Healing Process ◽  
Antioxidant Properties ◽  
Skin Damage ◽  
Hybrid Hydrogel ◽  
Hydrogel Scaffolds ◽  
Hybrid Hydrogels ◽  
Poly Acrylic Acid

Abstract Wound healing dressing is increasingly needed in clinical owing to the large quantity of skin damage annually. Excessive reactive oxygen species (ROS) produced through internal or external environmental influences can lead to lipid peroxidation, protein denaturation, and even DNA damage, and ultimately have harmful effects on cells. Aiming to sufficiently contact with the wound microenvironment and scavenge ROS, superabsorbent poly (acrylic acid) and antioxidant poly (ester amide) (PAA/PEA) hybrid hydrogel has been developed to enhance wound healing. The physical and chemical properties of hybrid hydrogels were studied by Fourier-transform infrared (FTIR) absorption spectrum, compression, swelling, degradation, etc. Besides, the antioxidant properties of hybrid hydrogels can be investigated through the free radical scavenging experiment, and corresponding antioxidant indicators have been tested at the cellular level. Hybrid hydrogel scaffolds supported the proliferation of human umbilical vein endothelial cells and fibroblasts, as well as accelerated angiogenesis and skin regeneration in wounds. The healing properties of wounds in vivo were further assessed on mouse skin wounds. Results showed that PAA/PEA hybrid hydrogel scaffolds significantly accelerated the wound healing process through enhancing granulation formation and re-epithelialization. In summary, these superabsorbent and antioxidative hybrid hydrogels could be served as an excellent wound dressing for full-thickness wound healing.

scholarly journals Fabrication of Cellulose Nanocrystal-g-Poly(Acrylic Acid-Co-Acrylamide) Aerogels for Efficient Pb(II) Removal

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 333 ◽  
Author(s):  
Yifan Chen ◽  
Qian Li ◽  
Yujie Li ◽  
Qijun Zhang ◽  
Jingda Huang ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Adsorption Capacity ◽  
Langmuir Model ◽  
Cellulose Nanocrystal ◽  
Effective Removal ◽  
Pseudo Second Order ◽  
Repeated Use ◽  
Adsorption Desorption ◽  
Hydrolysis Of ◽  
Poly Acrylic Acid

In this work, cellulose nanocrystals (CNCs) obtained by the acid hydrolysis of waste bamboo powder were used to synthesize cellulose nanocrystal-g-poly(acrylic acid-co-acrylamide) (CNC-g-P(AA/AM)) aerogels via graft copolymerization followed by freeze-drying. The structure and morphology of the resulting aerogels were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), and the CNC-g-P(AA/AM) aerogels exhibited excellent absorbent properties and adsorption capacities. Subsequent Pb(II) adsorption studies showed that the kinetic data followed the pseudo-second-order equation, while the adsorption isotherms were best described using the Langmuir model. The maximum Pb(II) adsorption capacity calculated by the Langmuir model reached up to 366.3 mg/g, which is a capacity that outperformed that of the pure CNC aerogel. The CNC-g-P (AA/AM) aerogels become structurally stable through chemical cross-linking, which enabled them to be easily regenerated in HCl solution and retain the adsorption capacity after repeated use. The aerogels were found to maintain 81.3% removal efficiency after five consecutive adsorption–desorption cycles. Therefore, this study demonstrated an effective method for the fabrication of an aerogel adsorbent with an excellent reusability in the effective removal of Pb(II) from aqueous solutions.

scholarly journals Light-triggered nitric oxide (NO) release from photoresponsive polymersomes for corneal wound healing

2020 ◽  
Vol 11 (1) ◽  
pp. 186-194 ◽  
Author(s):  
Yutian Duan ◽  
Yong Wang ◽  
Xiaohu Li ◽  
Guozhen Zhang ◽  
Guoying Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Corneal Wound Healing ◽  
Corneal Wound ◽  
No Release ◽  
Nitric Oxide Releasing

Nitric oxide-releasing amphiphiles are successfully synthesized through direct polymerization and are engineered as photoresponsive polymersomes for biomedical applications.

Biodegradable hyaluronic acid-based, nitric oxide-releasing nanofibers for potential wound healing applications

2021 ◽  
Author(s):  
Kihak Gwon ◽  
Won Il Choi ◽  
Seonhwa Lee ◽  
Jin Sil Lee ◽  
Jae Ho Shin
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Hyaluronic Acid ◽  
Potential Application ◽  
Nitric Oxide Releasing

The biodegradable and nitric oxide (NO)-releasing hyaluronic acid (HA)-based nanofibers developed in this study have the potential application in wound healing.

Recent Advances in the Development of Nitric Oxide-Releasing Biomaterials and Their Application Potentials in Chronic Wound Healing

2021 ◽  
Author(s):  
Min Wu ◽  
Zhihui Lu ◽  
Keke Wu ◽  
Changwoo Nam ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Persistent Infection ◽  
Diabetic Foot ◽  
Chronic Wounds ◽  
Pressure Ulcers ◽  
Chronic Wound ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Nitric Oxide Releasing

Chronic wounds, such as pressure ulcers, vascular ulcers and diabetic foot ulcers (DFUs), often stays in a state of pathological inflammation and suffers from persistent infection, excess inflammation, and hypoxia,...

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