scholarly journals Modification of Amyloid-beta Peptide Aggregation via Photoactivation of Strained Ru(II) Polypyridyl Complexes

2021 ◽  
Author(s):  
Janaina Bataglioli ◽  
Luiza M. F. Gomes ◽  
Camille Maunoir ◽  
Jason Smith ◽  
Houston D. Cole ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Amyloid Beta ◽  
Neurodegenerative Disorder ◽  
Amyloid Beta Peptide ◽  
Peptide Aggregation ◽  
Irreversible Damage ◽  
Polypyridyl Complexes ◽  
Beta Peptide ◽  
Soluble P ◽  
The Brain

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive and irreversible damage to the brain. One of the hallmarks of the disease is the presence of both soluble...

scholarly journals Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns

RSC Advances ◽  
2017 ◽  
Vol 7 (50) ◽  
pp. 31714-31724 ◽  
Author(s):  
Antonella Battisti ◽  
Antonio Palumbo Piccionello ◽  
Antonella Sgarbossa ◽  
Silvia Vilasi ◽  
Caterina Ricci ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Amyloid Beta Peptide ◽  
Peptide Aggregation ◽  
New Concepts ◽  
Novel Drugs ◽  
Beta Peptide

This study suggests new concepts and potential difficulties in the design of novel drugs against diverse amyloidoses, including Alzheimer’s disease.

P1-039: Inhibitors of amyloid beta peptide aggregation: Toward new drugs against Alzheimer's disease

2015 ◽  
Vol 11 (7S_Part_7) ◽  
pp. P352-P353 ◽  
Author(s):  
Olivia Berthoumieu ◽  
Peter Faller ◽  
Andrew J. Doig ◽  
Philippe Derreumaux
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
New Drugs ◽  
Amyloid Beta Peptide ◽  
Peptide Aggregation ◽  
Beta Peptide

A bifunctional non-natural tetrapeptide modulates amyloid-beta peptide aggregation in the presence of Cu(ii)

Metallomics ◽  
2014 ◽  
Vol 6 (12) ◽  
pp. 2189-2192 ◽  
Author(s):  
Maripaz Márquez ◽  
Luis M. Blancas-Mejía ◽  
Adriana Campos ◽  
Luis Rojas ◽  
Gilberto Castañeda-Hernández ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Therapeutic Potential ◽  
Amyloid Beta Peptide ◽  
Peptide Aggregation ◽  
Beta Peptide ◽  
Aβ Aggregation

A novel bifunctional non-natural tetrapeptide, Met-Asp-d-Trp-Aib, is capable of binding copper, competing with amyloid-beta peptide (Aβ) for Cu(ii), and modulating Aβ aggregation. The study of this tetrapeptide provides further insights into the role of Cu(ii) in the Aβ aggregation pathway, and into the design of compounds with therapeutic potential for Alzheimer's disease.

scholarly journals A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation

2019 ◽  
Vol 10 (6) ◽  
pp. 1634-1643 ◽  
Author(s):  
Luiza M. F. Gomes ◽  
Atif Mahammed ◽  
Kathleen E. Prosser ◽  
Jason R. Smith ◽  
Michael A. Silverman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Reactive Oxygen Species ◽  
Amyloid Beta ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Amyloid Beta Peptide ◽  
Peptide Aggregation ◽  
Oxygen Species ◽  
Beta Peptide ◽  
Catalytic Antioxidant

An Fe corrole is shown to bind to the amyloid-beta peptide and limit reactive oxygen species generation and peptide aggregation of relevance to Alzheimer's disease.

scholarly journals Zinc Metalloproteinases and Amyloid Beta-Peptide Metabolism: The Positive Side of Proteolysis in Alzheimer's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Mallory Gough ◽  
Catherine Parr-Sturgess ◽  
Edward Parkin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Neuronal Death ◽  
Amyloid Beta Peptide ◽  
Positive Side ◽  
Beta Peptide ◽  
Peptide Metabolism ◽  
The Brain

Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (A-)peptides in the brain causing progressive neuronal death. A-peptides are produced by aspartyl proteinase-mediated cleavage of the larger amyloid precursor protein (APP). In contrast to this detrimental “amyloidogenic” form of proteolysis, a range of zinc metalloproteinases can process APP via an alternative “nonamyloidogenic” pathway in which the protein is cleaved within its A region thereby precluding the formation of intact A-peptides. In addition, other members of the zinc metalloproteinase family can degrade preformed A-peptides. As such, the zinc metalloproteinases, collectively, are key to downregulating A generation and enhancing its degradation. It is the role of zinc metalloproteinases in this “positive side of proteolysis in Alzheimer's disease” that is discussed in the current paper.

Detecting bioactive amyloid beta peptide species in Alzheimer's disease

2004 ◽  
Vol 91 (3) ◽  
pp. 648-656 ◽  
Author(s):  
Yuanbin Liu ◽  
Richard Dargusch ◽  
Cindy Banh ◽  
Carol A. Miller ◽  
David Schubert
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Amyloid Beta Peptide ◽  
Beta Peptide
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