Process intensification of ozonolysis reactions using dedicated microstructured reactors

2021 ◽  
Author(s):  
Dominik Polterauer ◽  
D. M. Roberge ◽  
Paul Hanselmann ◽  
Petteri Elsner ◽  
Christopher A Hone ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Process Intensification ◽  
Green Solvents ◽  
Chemical Manufacture ◽  
Microstructured Reactors

Ozonolysis reactions are generally high-yielding, highly selective, and sustainable processes, especially when performed in green solvents. However, ozonolysis is underutilized in organic synthesis and chemical manufacture due to the safety...

Green Solvents in Organic Synthesis: An Overview II

2016 ◽  
Vol 20 (15) ◽  
pp. 1576-1583 ◽  
Author(s):  
Karem Shanab ◽  
Catharina Neudorfer ◽  
Helmut Spreitzer
Keyword(s):  
Organic Synthesis ◽  
Green Solvents

Organic Synthesis Engineering

2001 ◽  
Author(s):  
L. K. Doraiswamy
Keyword(s):  
Organic Synthesis ◽  
Phase Transfer ◽  
Heterogeneous Systems ◽  
Process Intensification ◽  
Reaction Rates ◽  
Main Theme ◽  
Scale Production ◽  
Phase Transfer Catalysts ◽  
Industrial Scale Production

This book will formally launch "organic synthesis engineering" as a distinctive field in the armory of the reaction engineer. Its main theme revolves around two developments: catalysis and the role of process intensification in enhancing overall productivity. Each of these two subjects are becoming increasingly useful in organic synthesis engineering, especially in the production of medium and small volume chemicals and enhancing reaction rates by extending laboratory techniques, such as ultrasound, phase transfer catalysts, membrane reactor, and microwaves, to industrial scale production. This volume describes the applications of catalysis in organic synthesis and outlines different techniques of reaction rate and/or selectivity enhancement against a background of reaction engineering principles for both homogeneous and heterogeneous systems.

CATALYTIC ORGANIC SYNTHESIS: A NEW PARADIGM IN INDUSTRIAL PROCESS INTENSIFICATION

2014 ◽  
pp. 329-374
Author(s):  
Gangavaram Sharma ◽  
Palakodety Krishna ◽  
Venkata Doddi ◽  
Sudhir Kashyap ◽  
Post Reddy
Keyword(s):  
Organic Synthesis ◽  
Industrial Process ◽  
Process Intensification ◽  
New Paradigm

Electrochemical microstructured reactors: design and application in organic synthesis

2009 ◽  
Vol 39 (12) ◽  
pp. 2297-2313 ◽  
Author(s):  
A. Ziogas ◽  
G. Kolb ◽  
M. O’Connell ◽  
A. Attour ◽  
F. Lapicque ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Microstructured Reactors ◽  
Design And Application

Green Solvents in Organic Synthesis: An Overview

2013 ◽  
Vol 17 (11) ◽  
pp. 1179-1187 ◽  
Author(s):  
Karem Shanab ◽  
Cathanna Neudorfer ◽  
Eva Schirmer ◽  
Helmut Spreitzer
Keyword(s):  
Organic Synthesis ◽  
Green Solvents

Green Synthetic Methodology of (E)-2-cyano-3-aryl Selective Knoevenagel Adducts Under Microwave Irradiation

2019 ◽  
Vol 6 (1) ◽  
pp. 54-60 ◽  
Author(s):  
David Esteban Quintero Jimenez ◽  
Lucas Lima Zanin ◽  
Luan Farinelli Diniz ◽  
Javier Ellena ◽  
André Luiz Meleiro Porto
Keyword(s):  
Organic Chemistry ◽  
Microwave Irradiation ◽  
Organic Synthesis ◽  
Knoevenagel Condensation ◽  
Green Solvents ◽  
Nacl Solution ◽  
Synthetic Methodology ◽  
X Ray ◽  
Basic Catalysts ◽  
High Yields

Background: The Knoevenagel condensation is an important reaction in organic chemistry because of its capacity to form new C-C bonds and its products are mainly used in organic synthesis as intermediates, due to the large number of reactions they can undergo. Based on the importance of the Knoevenagel adducts, a sustainable synthetic methodology was developed employing microwave irradiation. Objective: Develop a synthetic methodology employing microwave irradiation and green solvents to obtain Knoevenagel adducts with high yields. Methods: Knoevenagel condensation reactions were evaluated with different basic catalysts, as well as in the presence or absence of microwave irradiation. The scope of the reaction was expanded using different aldehydes, cyanoacetamide or methyl cyanoacetate. The geometry of the formed products was also evaluated. Results: After the optimization process, the reactions between aldehydes and cyanoacetamide were performed with triethylamine as catalyst, in the presence of microwave irradiation, in 35 minutes, using NaCl solution as solvent and resulted in high yields 90-99%. The reactions performed between aldehydes and methyl cyanoacetate were also performed under these conditions, but showed better yields with EtOH as solvent 70-90%. Finally, from X-ray analysis, the (E)-geometry of these compounds was confirmed. Conclusion: In this study we developed synthetic methodology of Knoevenagel condensation using triethylamine, green solvents and microwave irradiation. In 35 minutes, products with high yields (70- 99%) were obtained and the (E)-geometry of the adducts was confirmed.

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