scholarly journals Solution-phase synthesis of oligodeoxyribonucleotides using the H-phosphonate method with N-unprotected 5′-phosphite monomers

RSC Advances ◽  
2021 ◽  
Vol 11 (60) ◽  
pp. 38094-38107
Author(s):  
Hiromasa Matsuda ◽  
Erina Yoshida ◽  
Takaaki Shinoda ◽  
Kazuki Sato ◽  
Rintaro Iwata Hara ◽  
...  
Keyword(s):  
Single Step ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
New Strategy

A new strategy for a solution-phase synthesis of oligodeoxyribonucleotides with 5′-phosphite monomers synthesized in a single step from unprotected 2′-deoxyribonucleosides.

Solution phase synthesis of oligonucleotides by the phosphoramidite method using solid supported reagents

2005 ◽  
Author(s):  
François Morvan ◽  
Aude-Emmanuelle Navarro ◽  
Cécile Dueymes ◽  
Ilaria Adamo ◽  
Andreas Schoenberger ◽  
...  
Keyword(s):  
Solution Phase ◽  
Phase Synthesis ◽  
Solution Phase Synthesis

Polymer-Assisted Parallel Solution Phase Synthesis of Substituted Benzimidazoles.

ChemInform ◽  
2010 ◽  
Vol 33 (35) ◽  
pp. 123-123
Author(s):  
Young K. Yun ◽  
John A. Porco Jr. ◽  
Jeff Labadie
Keyword(s):  
Solution Phase ◽  
Phase Synthesis ◽  
Parallel Solution ◽  
Solution Phase Synthesis

Solution-phase synthesis of monodispersed SnTe nanocrystallites at room temperature

2003 ◽  
Vol 6 (2) ◽  
pp. 181-184 ◽  
Author(s):  
Changhua An ◽  
Kaibin Tang ◽  
Bin Hai ◽  
Guozhen Shen ◽  
Chunrui Wang ◽  
...  
Keyword(s):  
Room Temperature ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Solution Phase Synthesis

Synthesis of O-Phosphotyrosine-Containing Peptides. II. Solution-Phase Synthesis of Asn-Glu-PTyr-Thr-Ala Through Methyl Phosphate Protection

1989 ◽  
Vol 42 (9) ◽  
pp. 1519 ◽  
Author(s):  
RM Valerio ◽  
JW Perich ◽  
EA Kitas ◽  
PF Alewood ◽  
RB Johns
Keyword(s):  
Trifluoroacetic Acid ◽  
Dimethyl Sulfide ◽  
Solution Phase ◽  
High Yield ◽  
Phase Synthesis ◽  
Rous Sarcoma ◽  
Naturally Occurring ◽  
Solution Phase Synthesis ◽  
Sarcoma Virus ◽  
Methyl Phosphate

The PTyr (O-phosphotyrosine) pentapeptide H-Asn-Glu-Tyr(PO3H2)-Thr-Ala-OH.HO2CCF3, which is a naturally occurring sequence from the autophosphorylated Rous sarcoma virus pp60V-SrC, was prepared in high yield by the use of Boc-Tyr(PO3Me2)-OH in the Boc mode of solution-phase peptide synthesis. The protected pentapeptide, Z-Asn-Glu(OBzl)-Tyr(PO3Me2)-Thr(Bzl)-Ala-OBzl, was deprotected by a two-stage procedure which involved initial palladium-catalysed hydrogenolysis followed by the removal of the phosphate methyl groups by the use of one of the following treatments: (A) 10% bromotrimethylsilane/acetonitrile, (B) 1 M bromotrimethylsilane/thioanisole in trifluoroacetic acid, or (C) trifluoromethanesulfonic acid/trifluoroacetic acid/dimethyl sulfide/m-cresol.

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