Synthesis of O-Phosphotyrosine-Containing Peptides. II. Solution-Phase Synthesis of Asn-Glu-PTyr-Thr-Ala Through Methyl Phosphate Protection

1989 ◽  
Vol 42 (9) ◽  
pp. 1519 ◽  
Author(s):  
RM Valerio ◽  
JW Perich ◽  
EA Kitas ◽  
PF Alewood ◽  
RB Johns
Keyword(s):  
Trifluoroacetic Acid ◽  
Dimethyl Sulfide ◽  
Solution Phase ◽  
High Yield ◽  
Phase Synthesis ◽  
Rous Sarcoma ◽  
Naturally Occurring ◽  
Solution Phase Synthesis ◽  
Sarcoma Virus ◽  
Methyl Phosphate

The PTyr (O-phosphotyrosine) pentapeptide H-Asn-Glu-Tyr(PO3H2)-Thr-Ala-OH.HO2CCF3, which is a naturally occurring sequence from the autophosphorylated Rous sarcoma virus pp60V-SrC, was prepared in high yield by the use of Boc-Tyr(PO3Me2)-OH in the Boc mode of solution-phase peptide synthesis. The protected pentapeptide, Z-Asn-Glu(OBzl)-Tyr(PO3Me2)-Thr(Bzl)-Ala-OBzl, was deprotected by a two-stage procedure which involved initial palladium-catalysed hydrogenolysis followed by the removal of the phosphate methyl groups by the use of one of the following treatments: (A) 10% bromotrimethylsilane/acetonitrile, (B) 1 M bromotrimethylsilane/thioanisole in trifluoroacetic acid, or (C) trifluoromethanesulfonic acid/trifluoroacetic acid/dimethyl sulfide/m-cresol.

scholarly journals High-Yield Solution-Phase Synthesis of Di- and Trinucleotide Blocks Assisted by Polymer-Supported Reagents.

ChemInform ◽  
2005 ◽  
Vol 36 (44) ◽  
Author(s):  
Cecile Dueymes ◽  
Andreas Schoenberger ◽  
Ilaria Adamo ◽  
Aude-Emmanuelle Navarro ◽  
Albert Meyer ◽  
...  
Keyword(s):  
Solution Phase ◽  
High Yield ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
Polymer Supported

High-Yield Solution-Phase Synthesis of Di- and Trinucleotide Blocks Assisted by Polymer-Supported Reagents

2005 ◽  
Vol 7 (16) ◽  
pp. 3485-3488 ◽  
Author(s):  
Cécile Dueymes ◽  
Andreas Schönberger ◽  
Ilaria Adamo ◽  
Aude-Emmanuelle Navarro ◽  
Albert Meyer ◽  
...  
Keyword(s):  
Solution Phase ◽  
High Yield ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
Polymer Supported

Solution Phase Synthesis and Conformational Analysis of Glu-Ser-Leu-Ser-Ser-Ser-Glu-Glu-NHMe and Its Peptide Congeners (Non-Phosphorylated Region 14-21 of Bovine β-Casein A2)

1992 ◽  
Vol 45 (11) ◽  
pp. 1857 ◽  
Author(s):  
JW Perich ◽  
RB Johns
Keyword(s):  
Conformational Analysis ◽  
Peptide Synthesis ◽  
Reversed Phase ◽  
Solution Phase ◽  
High Yield ◽  
Reversed Phase Chromatography ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
Yield And Purity ◽  
Protected Peptides

The octapeptide H-Glu-Ser-Leu-Ser-Ser-Ser-Glu-Glu-NHMe.CF3CO2H and its five shorter peptide congeners (from tripeptide to heptapeptide ) were prepared in high yield and purity by the Boc mode of solution phase peptide synthesis followed by palladium- catalysed hydrogenolytic deprotection of the six protected peptides in 50% CF3CO2H/CH3CO2H solution. The analysis of the six peptides by 13C n.m.r. spectroscopy and C18 reversed-phase chromatography suggested that a structural arrangement commenced at the hexapeptide stage and was considered to be due to the formation of a β-turn conformation.

A Low Temperature, Solution Phase Synthesis of III-V Semiconductor Nanocrystals

1994 ◽  
Vol 351 ◽  
Author(s):  
Shreyas S. Kher ◽  
Richard L. Wells
Keyword(s):  
Semiconductor Nanocrystals ◽  
Solution Phase ◽  
High Yield ◽  
Group V ◽  
Phase Synthesis ◽  
Group Iii ◽  
Wide Range ◽  
Solution Phase Synthesis ◽  
Temperature Solution ◽  
High Yields

ABSTRACTNanocrystalline materials have been intensely investigated in the recent past due to the novel properties associated with size-quantized particles. We have developed a new method for high yield, solution phase synthesis of nanocrystalline III-V semiconductors which eliminates the use of substituted or unsubstituted Group V hydrides and Group III alkyls. Our approach consists of in situ syntheses of (Na/K)3E (E = P, As, Sb) in aromatic solvents and subsequent reactions of these pnictides with Group III halide solutions in coordinating solvents. The nanocrystalline III-V semiconductors GaP, GaAs, GaSb, InP, InAs and InSb are readily prepared in a wide range of particle sizes (4–36 nm) and in high yields. The resultant Ill-V materials have been characterized by XRD, EDXA, TEM and elemental analyses.

Rapid and high-yield solution-phase synthesis of DOTA-Tyr3-octreotide and DOTA-Tyr3-octreotate using unprotected DOTA

2003 ◽  
Vol 44 (11) ◽  
pp. 2393-2396 ◽  
Author(s):  
Margret Schottelius ◽  
Markus Schwaiger ◽  
Hans-Jürgen Wester
Keyword(s):  
Solution Phase ◽  
High Yield ◽  
Phase Synthesis ◽  
Solution Phase Synthesis

Solution phase synthesis of oligonucleotides by the phosphoramidite method using solid supported reagents

2005 ◽  
Author(s):  
François Morvan ◽  
Aude-Emmanuelle Navarro ◽  
Cécile Dueymes ◽  
Ilaria Adamo ◽  
Andreas Schoenberger ◽  
...  
Keyword(s):  
Solution Phase ◽  
Phase Synthesis ◽  
Solution Phase Synthesis

Polymer-Assisted Parallel Solution Phase Synthesis of Substituted Benzimidazoles.

ChemInform ◽  
2010 ◽  
Vol 33 (35) ◽  
pp. 123-123
Author(s):  
Young K. Yun ◽  
John A. Porco Jr. ◽  
Jeff Labadie
Keyword(s):  
Solution Phase ◽  
Phase Synthesis ◽  
Parallel Solution ◽  
Solution Phase Synthesis
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