scholarly journals Recent advances of N-heterocyclic carbenes in the applications of constructing carbo- and heterocyclic frameworks with potential biological activity

RSC Advances ◽  
2021 ◽  
Vol 11 (60) ◽  
pp. 38060-38078
Author(s):  
Mei-Mei Li ◽  
Xiaozhen Chen ◽  
Yun Deng ◽  
Jun Lu

A general picture of utilization of NHCs in constructing several kinds of bioactive cyclic skeletons.

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2511
Author(s):  
Petra R. Varga ◽  
György Keglevich

The Kabachnik–Fields reaction, comprising the condensation of an amine, oxo compound and a P-reagent (generally a >P(O)H species or trialkyl phosphite), still attracts interest due to the challenging synthetic procedures and the potential biological activity of the resulting α-aminophosphonic derivatives. Following the success of the first part (Molecules 2012, 17, 12821), here we summarize the synthetic developments in this field accumulated in the last decade. The procedures compiled include catalytic accomplishments as well as catalyst-free and/or solvent-free “greener” protocols. The products embrace α-aminophosphonates, α-aminophosphinates, and α-aminophosphine oxides along with different bis derivatives from the double phospha-Mannich approach. The newer developments of the aza-Pudovik reactions are also included.


2021 ◽  
Author(s):  
Robert M. Hohlman ◽  
David H. Sherman

This review covers isolation, biological activity, an overview of total synthesis efforts and recent biosynthetic discoveries related to hapalindole-type indole alkaloids.


2017 ◽  
Vol 8 (12) ◽  
pp. 4325-4330 ◽  
Author(s):  
Kenji Sato

While it was difficult to detect food-derived peptide in blood (A), recent advances enables identify them (B) and examine their biological activities.


2008 ◽  
Vol 183 (6) ◽  
pp. 1323-1343 ◽  
Author(s):  
E. M. Keshk ◽  
S. I. El-Desoky ◽  
M. A. A. Hammouda ◽  
A. H. Abdel-Rahman ◽  
A. G. Hegazi

Author(s):  
Kirill Popov ◽  
Tatyana Volovnenko ◽  
Julian Volovenko

The reactions of benzo[e][2,1]thiazine-4-chloro-3-carbaldehydes 1 and benzo[e][2,1]thiazine-4-chloro-3-carbonitriles 2 with a number of oxidizing and reducing agents are reported. A number of new, highly functionalized benzo[e][2,1]thiazine derivatives having potential biological activity were synthesized and described.


2018 ◽  
Vol 56 (1) ◽  
pp. 18-31 ◽  
Author(s):  
Islam H. El Azab ◽  
Ola A. Abu Ali ◽  
Aishah H. El‐Zahrani ◽  
Adil A. Gobouri ◽  
Tariq A. Altalhi

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